
DOI . ORG {
}
Title[redir]:
The Glymphatic System: A Beginner’s Guide | Neurochemical Research
Description:
The glymphatic system is a recently discovered macroscopic waste clearance system that utilizes a unique system of perivascular tunnels, formed by astroglial cells, to promote efficient elimination of soluble proteins and metabolites from the central nervous system. Besides waste elimination, the glymphatic system also facilitates brain-wide distribution of several compounds, including glucose, lipids, amino acids, growth factors, and neuromodulators. Intriguingly, the glymphatic system function mainly during sleep and is largely disengaged during wakefulness. The biological need for sleep across all species may therefore reflect that the brain must enter a state of activity that enables elimination of potentially neurotoxic waste products, including β-amyloid. Since the concept of the glymphatic system is relatively new, we will here review its basic structural elements, organization, regulation, and functions. We will also discuss recent studies indicating that glymphatic function is suppressed in various diseases and that failure of glymphatic function in turn might contribute to pathology in neurodegenerative disorders, traumatic brain injury and stroke.
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Keywords {🔍}
pubmed, google, scholar, article, cas, central, brain, fluid, cerebrospinal, system, choroid, res, disease, plexus, glymphatic, doi, cerebral, physiol, sleep, med, perivascular, neurosci, dois, function, injury, nat, clearance, sci, amyloid, nervous, traumatic, cell, neurol, regulation, biol, rev, usa, human, flow, alzheimers, protein, tau, distribution, neurodegenerative, lymphatic, mechanisms, development, astrocytes, neuronal, blood,
Topics {✒️}
virchow–robin spaces month download article/chapter iben lundgaard & maiken nedergaard central nervous system amyloid-beta-induced neuronal dysfunction locus coeruleus-noradrenergic system 5-year single-center experience dependent acid-base transporters cerebrospinal fluid secretion peripheral nervous system damkier hh rapid-eye-movement sleep differential arterial/venous expression stress-induced gene regulation state-dependent cognitive processes apoe isoform—specific disruption human amyloid-beta synthesis blood-cerebrospinal fluid barriers full article pdf virchow–robin aging brain cerebral lymphatic system nadia aalling jessen facilitates brain-wide distribution glymphatic system function brain lymphatic system blood-brain barrier phenotype traumatic brain injury neurodegenerative diseases perivascular spaces nervous system brain-wide pathway stilbenes inhibit exchange strittmatter wj late onset families cerebrospinal fluid flow cardiac-related pulsation gray matter astrocytes privacy choices/manage cookies article jessen segal mb neuronal activity regulates magnetic resonance images paravascular fluid pathways cerebral interstitial fluid vivo imaging reveals cerebral blood flow paravascular clearance pathways traumatic brain injuries age-dependent flux
Questions {❓}
- Gaberel T, Gakuba C, Goulay R et al (2014) Impaired glymphatic perfusion after strokes revealed by contrast-enhanced MRI: a new target for fibrinolysis?
- Iliff JJ, Nedergaard M (2013) Is there a cerebral lymphatic system?
- Koh L, Zakharov A, Johnston M (2005) Integration of the subarachnoid space and lymphatics: Is it time to embrace a new concept of cerebrospinal fluid absorption?
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headline:The Glymphatic System: A Beginner’s Guide
description:The glymphatic system is a recently discovered macroscopic waste clearance system that utilizes a unique system of perivascular tunnels, formed by astroglial cells, to promote efficient elimination of soluble proteins and metabolites from the central nervous system. Besides waste elimination, the glymphatic system also facilitates brain-wide distribution of several compounds, including glucose, lipids, amino acids, growth factors, and neuromodulators. Intriguingly, the glymphatic system function mainly during sleep and is largely disengaged during wakefulness. The biological need for sleep across all species may therefore reflect that the brain must enter a state of activity that enables elimination of potentially neurotoxic waste products, including β-amyloid. Since the concept of the glymphatic system is relatively new, we will here review its basic structural elements, organization, regulation, and functions. We will also discuss recent studies indicating that glymphatic function is suppressed in various diseases and that failure of glymphatic function in turn might contribute to pathology in neurodegenerative disorders, traumatic brain injury and stroke.
datePublished:2015-05-07T00:00:00Z
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Astrocytes
Perivascular spaces
Virchow–Robin spaces
Cerebrospinal fluid secretion
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description:The glymphatic system is a recently discovered macroscopic waste clearance system that utilizes a unique system of perivascular tunnels, formed by astroglial cells, to promote efficient elimination of soluble proteins and metabolites from the central nervous system. Besides waste elimination, the glymphatic system also facilitates brain-wide distribution of several compounds, including glucose, lipids, amino acids, growth factors, and neuromodulators. Intriguingly, the glymphatic system function mainly during sleep and is largely disengaged during wakefulness. The biological need for sleep across all species may therefore reflect that the brain must enter a state of activity that enables elimination of potentially neurotoxic waste products, including β-amyloid. Since the concept of the glymphatic system is relatively new, we will here review its basic structural elements, organization, regulation, and functions. We will also discuss recent studies indicating that glymphatic function is suppressed in various diseases and that failure of glymphatic function in turn might contribute to pathology in neurodegenerative disorders, traumatic brain injury and stroke.
datePublished:2015-05-07T00:00:00Z
dateModified:2015-05-07T00:00:00Z
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The glymphatic system
Astrocytes
Perivascular spaces
Virchow–Robin spaces
Cerebrospinal fluid secretion
Sleep
Aging
Neurodegenerative diseases
Traumatic brain injury
Neurosciences
Neurochemistry
Biochemistry
general
Cell Biology
Neurology
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