We are analyzing https://link.springer.com/article/10.1186/2045-8118-11-16.

Title:
A new look at cerebrospinal fluid movement | Fluids and Barriers of the CNS
Description:
Brinker et al. extensively reviewed recent findings about CSF circulation in a recent article: “A new look at cerebrospinal circulation”, but did not analyze some important available data in sufficient detail. For example, our findings as well as some clinical data and experimental results obtained from different animal species, do not support unidirectional CSF circulation but strongly suggest that there are cardiac cycle-dependent systolic-diastolic to-and-fro cranio-spinal CSF movements. These are based on: a) physiological oscillations of arterial and venous blood during cranio-spinal blood circulation; b) respiratory activity, and c) body activity and posture. That kind of complex CSF movement could explain the observed distribution of many different substances in all directions along the CSF system and within central nervous system tissue. It seems that efflux transport systems at capillary endothelium may be more important for brain homeostasis than the removal of metabolites by CSF flow. Thus, when discussing the CSF dynamics we suggest that a more appropriate term would be CSF movement rather than CSF circulation.
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Keywords {🔍}

csf, fluid, article, cerebrospinal, google, scholar, circulation, klarica, brain, pubmed, system, water, orešković, central, hypothesis, space, movement, pressure, experimental, physiology, results, distribution, substances, nervous, flow, cats, cas, cns, ventricles, research, volume, dynamics, data, information, recent, blood, subarachnoid, molecular, experiments, aquaporin, privacy, cookies, barriers, open, access, findings, based, tissue, transport, inside,

Topics {✒️}

cardiac cycle-dependent systolic-diastolic central nervous system cranio-spinal blood circulation rat blood–brain barrier cerebrospinal fluid system article download pdf virchow-robin paravascular space cranio-spinal csf space cerebrospinal fluid movement efflux transport systems cerebral blood flow cerebrospinal fluid inside central csf compartment privacy choices/manage cookies cerebrospinal fluid pressure cerebrospinal fluid circulation paravascular fluid movement open access license darko orešković �paravascular” fluid circulation systems physiology [3–11] entire csf system mri flow studies contrast-enhanced mri brain-wide pathway references brinker including amyloid β hydrostatic pressure gradient european economic area main content log plastic cannula introduced classical understanding exists wild-type mice main misunderstanding relating acute aqueductal blockade impaired craniospinal communication magn reson imaging article orešković continuous experimental research conditions privacy policy epidural space filled cerebrospinal fluid fluids barriers cns long-standing argument proteins thin pial cells neuroscience acta physiol scand authors contributed equally spinal dura mater

Questions {❓}

But if there is no unidirectional CSF “circulation”, as is proposed by our hypothesis, in what way would one describe CSF dynamics?
Orešković D, Klarica M, Vukić M: Does the secretion and circulation of the cerebrospinal fluid really exist?
Orešković D, Klarica M, Vukić M: The formation and circulation of cerebrospinal fluid inside the cat brain ventricles: a fact or an illusion?

Schema {🗺️}

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         headline:A new look at cerebrospinal fluid movement
         description:Brinker et al. extensively reviewed recent findings about CSF circulation in a recent article: “A new look at cerebrospinal circulation”, but did not analyze some important available data in sufficient detail. For example, our findings as well as some clinical data and experimental results obtained from different animal species, do not support unidirectional CSF circulation but strongly suggest that there are cardiac cycle-dependent systolic-diastolic to-and-fro cranio-spinal CSF movements. These are based on: a) physiological oscillations of arterial and venous blood during cranio-spinal blood circulation; b) respiratory activity, and c) body activity and posture. That kind of complex CSF movement could explain the observed distribution of many different substances in all directions along the CSF system and within central nervous system tissue. It seems that efflux transport systems at capillary endothelium may be more important for brain homeostasis than the removal of metabolites by CSF flow. Thus, when discussing the CSF dynamics we suggest that a more appropriate term would be CSF movement rather than CSF circulation.
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      headline:A new look at cerebrospinal fluid movement
      description:Brinker et al. extensively reviewed recent findings about CSF circulation in a recent article: “A new look at cerebrospinal circulation”, but did not analyze some important available data in sufficient detail. For example, our findings as well as some clinical data and experimental results obtained from different animal species, do not support unidirectional CSF circulation but strongly suggest that there are cardiac cycle-dependent systolic-diastolic to-and-fro cranio-spinal CSF movements. These are based on: a) physiological oscillations of arterial and venous blood during cranio-spinal blood circulation; b) respiratory activity, and c) body activity and posture. That kind of complex CSF movement could explain the observed distribution of many different substances in all directions along the CSF system and within central nervous system tissue. It seems that efflux transport systems at capillary endothelium may be more important for brain homeostasis than the removal of metabolites by CSF flow. Thus, when discussing the CSF dynamics we suggest that a more appropriate term would be CSF movement rather than CSF circulation.
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         Classic hypothesis of cerebrospinal physiology
         Cerebrospinal fluid circulation
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         Cerebrospinal fluid secretion
         Aquaporin
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         Hematology
         Neurobiology
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