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DOI . ORG {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Keywords
  7. Topics
  8. Questions
  9. Schema
  10. External Links
  11. Analytics And Tracking
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  13. Hosting Providers
  14. CDN Services

We began analyzing https://link.springer.com/article/10.1007/s10555-022-10023-9, but it redirected us to https://link.springer.com/article/10.1007/s10555-022-10023-9. The analysis below is for the second page.

Title[redir]:
Heterogeneity and tumor evolution reflected in liquid biopsy in metastatic breast cancer patients: a review | Cancer and Metastasis Reviews
Description:
Breast cancer is a spatially and temporally dynamic disease in which differently evolving genetic clones are responsible for progression and clinical outcome. We review tumor heterogeneity and clonal evolution from studies comparing primary tumors and metastasis and discuss plasma circulating tumor DNA as a powerful real-time approach for monitoring the clonal landscape of breast cancer during treatment and recurrence. We found only a few early studies exploring clonal evolution and heterogeneity through analysis of multiregional tissue biopsies of different progression steps in comparison with circulating tumor DNA (ctDNA) from blood plasma. The model of linear progression seemed to be more often reported than the model of parallel progression. The results show complex routes to metastasis, however, and plasma most often reflected metastasis more than primary tumor. The described patterns of evolution and the polyclonal nature of breast cancer have clinical consequences and should be considered during patient diagnosis and treatment selection. Current studies focusing on the relevance of clonal evolution in the clinical setting illustrate the role of liquid biopsy as a noninvasive biomarker for monitoring clonal progression and response to treatment. In the clinical setting, circulating tumor DNA may be an ideal support for tumor biopsies to characterize the genetic landscape of the metastatic disease and to improve longitudinal monitoring of disease dynamics and treatment effectiveness through detection of residual tumor after resection, relapse, or metastasis within a particular patient.

Matching Content Categories {๐Ÿ“š}

  • Health & Fitness
  • Education
  • Science

Content Management System {๐Ÿ“}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {๐Ÿ“ˆ}

What is the average monthly size of doi.org audience?

๐ŸŒ  Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
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How Does Doi.org Make Money? {๐Ÿ’ธ}

We can't figure out the monetization strategy.

The purpose of some websites isn't monetary gain; they're meant to inform, educate, or foster collaboration. Everyone has unique reasons for building websites. This could be an example. Doi.org might have a hidden revenue stream, but it's not something we can detect.

Keywords {๐Ÿ”}

cancer, breast, article, pubmed, google, scholar, cas, heterogeneity, tumor, evolution, clinical, dna, metastatic, circulating, nature, central, journal, clonal, metastasis, sequencing, medicine, progression, research, primary, odense, liquid, review, analysis, genetic, reviews, biopsy, plasma, treatment, tumour, cancers, oncology, plos, denmark, privacy, cookies, content, information, patients, kavan, disease, monitoring, landscape, biopsies, current, access,

Topics {โœ’๏ธ}

month download article/chapter powerful real-time approach tissue microarray-based study related subjects copy number aberrations hildebrandtย &ย mads thomassen full article pdf intra-tumour heterogeneity single-cell genome sequencing positron emission tomography circulating tumour dna cell-free dna primary breast cancers metastatic breast cancer circulating tumor dna privacy choices/manage cookies measuring clonal evolution breast cancer research nature publishing grou human breast cancer advanced cancer patients overcome tumor heterogeneity branched evolution revealed staging breast cancer tumor mutation load pathologic tumour size article cancer tumor evolution reflected breast cancer progression breast cancer metastasis digital breast tomosynthesis monitoring clonal progression breast cancer resistance circulating tumor cells national cancer institute article kavan linear genome evolution clinical cancer research nature reviews cancer single nucleotide resolution circulating cancer cells current studies focusing treatment selection multiple intratumoral assays breast cancer recurrence review tumor heterogeneity single-cell sequencing multiregional tissue biopsies personalized response monitoring immunohistochemical marker expression

Questions {โ“}

  • Intra-tumour heterogeneity: A looking glass for cancer?

Schema {๐Ÿ—บ๏ธ}

WebPage:
      mainEntity:
         headline:Heterogeneity and tumor evolution reflected in liquid biopsy in metastatic breast cancer patients: a review
         description:Breast cancer is a spatially and temporally dynamic disease in which differently evolving genetic clones are responsible for progression and clinical outcome. We review tumor heterogeneity and clonal evolution from studies comparing primary tumors and metastasis and discuss plasma circulating tumor DNA as a powerful real-time approach for monitoring the clonal landscape of breast cancer during treatment and recurrence. We found only a few early studies exploring clonal evolution and heterogeneity through analysis of multiregional tissue biopsies of different progression steps in comparison with circulating tumor DNA (ctDNA) from blood plasma. The model of linear progression seemed to be more often reported than the model of parallel progression. The results show complex routes to metastasis, however, and plasma most often reflected metastasis more than primary tumor. The described patterns of evolution and the polyclonal nature of breast cancer have clinical consequences and should be considered during patient diagnosis and treatment selection. Current studies focusing on the relevance of clonal evolution in the clinical setting illustrate the role of liquid biopsy as a noninvasive biomarker for monitoring clonal progression and response to treatment. In the clinical setting, circulating tumor DNA may be an ideal support for tumor biopsies to characterize the genetic landscape of the metastatic disease and to improve longitudinal monitoring of disease dynamics and treatment effectiveness through detection of residual tumor after resection, relapse, or metastasis within a particular patient.
         datePublished:2022-03-14T00:00:00Z
         dateModified:2022-03-14T00:00:00Z
         pageStart:433
         pageEnd:446
         sameAs:https://doi.org/10.1007/s10555-022-10023-9
         keywords:
            Clonal evolution
            Tumor heterogeneity
            Breast cancer
            ctDNA
            Liquid biopsy
            Cancer Research
            Oncology
            Biomedicine
            general
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                     address:
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                     address:
                        name:Department of Clinical Genetics, Odense University Hospital, Odense, Denmark
                        type:PostalAddress
                     type:Organization
                     name:University of Southern Denmark
                     address:
                        name:Department of Clinical Research, University of Southern Denmark, Odense, Denmark
                        type:PostalAddress
                     type:Organization
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               name:Marianne Vogsen
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                     address:
                        name:Department of Clinical Research, University of Southern Denmark, Odense, Denmark
                        type:PostalAddress
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                        name:Department of Oncology, Odense University Hospital, Odense, Denmark
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                     address:
                        name:Centre for Personalized Response Monitoring in Oncology (PREMIO), Odense University Hospital, Odense, Denmark
                        type:PostalAddress
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               name:Mads Thomassen
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                     address:
                        name:Department of Clinical Genetics, Odense University Hospital, Odense, Denmark
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                     type:Organization
                     name:University of Southern Denmark
                     address:
                        name:Department of Clinical Research, University of Southern Denmark, Odense, Denmark
                        type:PostalAddress
                     type:Organization
                     name:Odense University Hospital
                     address:
                        name:Centre for Personalized Response Monitoring in Oncology (PREMIO), Odense University Hospital, Odense, Denmark
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ScholarlyArticle:
      headline:Heterogeneity and tumor evolution reflected in liquid biopsy in metastatic breast cancer patients: a review
      description:Breast cancer is a spatially and temporally dynamic disease in which differently evolving genetic clones are responsible for progression and clinical outcome. We review tumor heterogeneity and clonal evolution from studies comparing primary tumors and metastasis and discuss plasma circulating tumor DNA as a powerful real-time approach for monitoring the clonal landscape of breast cancer during treatment and recurrence. We found only a few early studies exploring clonal evolution and heterogeneity through analysis of multiregional tissue biopsies of different progression steps in comparison with circulating tumor DNA (ctDNA) from blood plasma. The model of linear progression seemed to be more often reported than the model of parallel progression. The results show complex routes to metastasis, however, and plasma most often reflected metastasis more than primary tumor. The described patterns of evolution and the polyclonal nature of breast cancer have clinical consequences and should be considered during patient diagnosis and treatment selection. Current studies focusing on the relevance of clonal evolution in the clinical setting illustrate the role of liquid biopsy as a noninvasive biomarker for monitoring clonal progression and response to treatment. In the clinical setting, circulating tumor DNA may be an ideal support for tumor biopsies to characterize the genetic landscape of the metastatic disease and to improve longitudinal monitoring of disease dynamics and treatment effectiveness through detection of residual tumor after resection, relapse, or metastasis within a particular patient.
      datePublished:2022-03-14T00:00:00Z
      dateModified:2022-03-14T00:00:00Z
      pageStart:433
      pageEnd:446
      sameAs:https://doi.org/10.1007/s10555-022-10023-9
      keywords:
         Clonal evolution
         Tumor heterogeneity
         Breast cancer
         ctDNA
         Liquid biopsy
         Cancer Research
         Oncology
         Biomedicine
         general
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10555-022-10023-9/MediaObjects/10555_2022_10023_Fig1_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10555-022-10023-9/MediaObjects/10555_2022_10023_Fig2_HTML.png
      isPartOf:
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         name:Springer US
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      author:
            name:Stephanie Kavan
            url:http://orcid.org/0000-0001-5272-2118
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                  address:
                     name:Department of Clinical Genetics, Odense University Hospital, Odense, Denmark
                     type:PostalAddress
                  type:Organization
                  name:University of Southern Denmark
                  address:
                     name:Department of Clinical Research, University of Southern Denmark, Odense, Denmark
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Torben A. Kruse
            affiliation:
                  name:Odense University Hospital
                  address:
                     name:Department of Clinical Genetics, Odense University Hospital, Odense, Denmark
                     type:PostalAddress
                  type:Organization
                  name:University of Southern Denmark
                  address:
                     name:Department of Clinical Research, University of Southern Denmark, Odense, Denmark
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Marianne Vogsen
            affiliation:
                  name:University of Southern Denmark
                  address:
                     name:Department of Clinical Research, University of Southern Denmark, Odense, Denmark
                     type:PostalAddress
                  type:Organization
                  name:Odense University Hospital
                  address:
                     name:Department of Oncology, Odense University Hospital, Odense, Denmark
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Malene G. Hildebrandt
            affiliation:
                  name:University of Southern Denmark
                  address:
                     name:Department of Clinical Research, University of Southern Denmark, Odense, Denmark
                     type:PostalAddress
                  type:Organization
                  name:Odense University Hospital
                  address:
                     name:Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark
                     type:PostalAddress
                  type:Organization
                  name:Odense University Hospital
                  address:
                     name:Centre for Personalized Response Monitoring in Oncology (PREMIO), Odense University Hospital, Odense, Denmark
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Mads Thomassen
            affiliation:
                  name:Odense University Hospital
                  address:
                     name:Department of Clinical Genetics, Odense University Hospital, Odense, Denmark
                     type:PostalAddress
                  type:Organization
                  name:University of Southern Denmark
                  address:
                     name:Department of Clinical Research, University of Southern Denmark, Odense, Denmark
                     type:PostalAddress
                  type:Organization
                  name:Odense University Hospital
                  address:
                     name:Centre for Personalized Response Monitoring in Oncology (PREMIO), Odense University Hospital, Odense, Denmark
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      name:Odense University Hospital
      address:
         name:Department of Clinical Genetics, Odense University Hospital, Odense, Denmark
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      name:University of Southern Denmark
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         name:Department of Clinical Research, University of Southern Denmark, Odense, Denmark
         type:PostalAddress
      name:Odense University Hospital
      address:
         name:Department of Clinical Genetics, Odense University Hospital, Odense, Denmark
         type:PostalAddress
      name:University of Southern Denmark
      address:
         name:Department of Clinical Research, University of Southern Denmark, Odense, Denmark
         type:PostalAddress
      name:University of Southern Denmark
      address:
         name:Department of Clinical Research, University of Southern Denmark, Odense, Denmark
         type:PostalAddress
      name:Odense University Hospital
      address:
         name:Department of Oncology, Odense University Hospital, Odense, Denmark
         type:PostalAddress
      name:University of Southern Denmark
      address:
         name:Department of Clinical Research, University of Southern Denmark, Odense, Denmark
         type:PostalAddress
      name:Odense University Hospital
      address:
         name:Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark
         type:PostalAddress
      name:Odense University Hospital
      address:
         name:Centre for Personalized Response Monitoring in Oncology (PREMIO), Odense University Hospital, Odense, Denmark
         type:PostalAddress
      name:Odense University Hospital
      address:
         name:Department of Clinical Genetics, Odense University Hospital, Odense, Denmark
         type:PostalAddress
      name:University of Southern Denmark
      address:
         name:Department of Clinical Research, University of Southern Denmark, Odense, Denmark
         type:PostalAddress
      name:Odense University Hospital
      address:
         name:Centre for Personalized Response Monitoring in Oncology (PREMIO), Odense University Hospital, Odense, Denmark
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      name:Stephanie Kavan
      url:http://orcid.org/0000-0001-5272-2118
      affiliation:
            name:Odense University Hospital
            address:
               name:Department of Clinical Genetics, Odense University Hospital, Odense, Denmark
               type:PostalAddress
            type:Organization
            name:University of Southern Denmark
            address:
               name:Department of Clinical Research, University of Southern Denmark, Odense, Denmark
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Torben A. Kruse
      affiliation:
            name:Odense University Hospital
            address:
               name:Department of Clinical Genetics, Odense University Hospital, Odense, Denmark
               type:PostalAddress
            type:Organization
            name:University of Southern Denmark
            address:
               name:Department of Clinical Research, University of Southern Denmark, Odense, Denmark
               type:PostalAddress
            type:Organization
      name:Marianne Vogsen
      affiliation:
            name:University of Southern Denmark
            address:
               name:Department of Clinical Research, University of Southern Denmark, Odense, Denmark
               type:PostalAddress
            type:Organization
            name:Odense University Hospital
            address:
               name:Department of Oncology, Odense University Hospital, Odense, Denmark
               type:PostalAddress
            type:Organization
      name:Malene G. Hildebrandt
      affiliation:
            name:University of Southern Denmark
            address:
               name:Department of Clinical Research, University of Southern Denmark, Odense, Denmark
               type:PostalAddress
            type:Organization
            name:Odense University Hospital
            address:
               name:Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark
               type:PostalAddress
            type:Organization
            name:Odense University Hospital
            address:
               name:Centre for Personalized Response Monitoring in Oncology (PREMIO), Odense University Hospital, Odense, Denmark
               type:PostalAddress
            type:Organization
      name:Mads Thomassen
      affiliation:
            name:Odense University Hospital
            address:
               name:Department of Clinical Genetics, Odense University Hospital, Odense, Denmark
               type:PostalAddress
            type:Organization
            name:University of Southern Denmark
            address:
               name:Department of Clinical Research, University of Southern Denmark, Odense, Denmark
               type:PostalAddress
            type:Organization
            name:Odense University Hospital
            address:
               name:Centre for Personalized Response Monitoring in Oncology (PREMIO), Odense University Hospital, Odense, Denmark
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Department of Clinical Genetics, Odense University Hospital, Odense, Denmark
      name:Department of Clinical Research, University of Southern Denmark, Odense, Denmark
      name:Department of Clinical Genetics, Odense University Hospital, Odense, Denmark
      name:Department of Clinical Research, University of Southern Denmark, Odense, Denmark
      name:Department of Clinical Research, University of Southern Denmark, Odense, Denmark
      name:Department of Oncology, Odense University Hospital, Odense, Denmark
      name:Department of Clinical Research, University of Southern Denmark, Odense, Denmark
      name:Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark
      name:Centre for Personalized Response Monitoring in Oncology (PREMIO), Odense University Hospital, Odense, Denmark
      name:Department of Clinical Genetics, Odense University Hospital, Odense, Denmark
      name:Department of Clinical Research, University of Southern Denmark, Odense, Denmark
      name:Centre for Personalized Response Monitoring in Oncology (PREMIO), Odense University Hospital, Odense, Denmark
WebPageElement:
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External Links {๐Ÿ”—}(204)

Analytics and Tracking {๐Ÿ“Š}

  • Google Tag Manager

Libraries {๐Ÿ“š}

  • Clipboard.js
  • Prism.js

Emails and Hosting {โœ‰๏ธ}

Mail Servers:

  • mx.zoho.eu
  • mx2.zoho.eu
  • mx3.zoho.eu

Name Servers:

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CDN Services {๐Ÿ“ฆ}

  • Crossref

4.51s.