
NCBI . NLM . NIH . GOV {
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Title[redir]:
Breast cancer intra-tumor heterogeneity - PMC
Description:
In recent years it has become clear that cancer cells within a single tumor can display striking morphological, genetic and behavioral variability. Burgeoning genetic, epigenetic and phenomenological data support the existence of intra-tumor genetic ...
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Keywords {🔍}
doi, heterogeneity, tumor, cancer, genetic, cells, sequencing, breast, pubmed, google, scholar, mutations, cell, clonal, intratumor, cancers, pmc, tumors, free, article, aberrations, nature, dna, primary, single, evolution, situ, detection, stem, progression, genomic, model, analysis, csc, number, phenotypic, selective, cscs, mps, bulk, genome, singlecell, methods, ctcs, invasive, amplification, temporal, alterations, resistance, somatic,
Topics {✒️}
routinely formalin-fixed paraffin-embedded formalin-fixed paraffin-embedded pmc beta search assessing intra-tumor heterogeneity intra-tumor heterogeneity poses triple-negative breast cancer intra-tumor genetic heterogeneity intra-tumor genetic diversity single-molecule sequencing eliminates early-stage breast cancer cell free dna cell-free dna profiling intra-tumor heterogeneity acknowledgments sp detecting ultra-rare aberrations translating single-cell methods single-molecule sequencing platform single-molecule sequencing technologies study intra-tumor heterogeneity allele-specific expression directly single-cell sequencing genomics molecular analysis reveals publisher site pdf intra-tumour heterogeneity single-cell genetic analysis competing interests high-fidelity sequencing polygenomic breast cancers advanced breast cancer intra-tumor heterogeneity clinical applications intra-genic deletions cell-surface markers license information pmcid genetic heterogeneity observed triple-negative phenotype sequencing depth employed references marusyk pmc disclaimer somatic genetic aberrations nucleotide-excision repair overriding default estimates whilst structural variations invasive breast cancer single-molecule sequencing copy number alterations gene copy number somatic point mutations efficient tumour formation founder genetic events
Questions {❓}
- Breast tumor heterogeneity: cancer stem cells or clonal evolution?
- Intra-tumour heterogeneity: a looking glass for cancer?
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