We are analyzing https://link.springer.com/article/10.1007/s10555-022-10023-9.

Title:
Heterogeneity and tumor evolution reflected in liquid biopsy in metastatic breast cancer patients: a review | Cancer and Metastasis Reviews
Description:
Breast cancer is a spatially and temporally dynamic disease in which differently evolving genetic clones are responsible for progression and clinical outcome. We review tumor heterogeneity and clonal evolution from studies comparing primary tumors and metastasis and discuss plasma circulating tumor DNA as a powerful real-time approach for monitoring the clonal landscape of breast cancer during treatment and recurrence. We found only a few early studies exploring clonal evolution and heterogeneity through analysis of multiregional tissue biopsies of different progression steps in comparison with circulating tumor DNA (ctDNA) from blood plasma. The model of linear progression seemed to be more often reported than the model of parallel progression. The results show complex routes to metastasis, however, and plasma most often reflected metastasis more than primary tumor. The described patterns of evolution and the polyclonal nature of breast cancer have clinical consequences and should be considered during patient diagnosis and treatment selection. Current studies focusing on the relevance of clonal evolution in the clinical setting illustrate the role of liquid biopsy as a noninvasive biomarker for monitoring clonal progression and response to treatment. In the clinical setting, circulating tumor DNA may be an ideal support for tumor biopsies to characterize the genetic landscape of the metastatic disease and to improve longitudinal monitoring of disease dynamics and treatment effectiveness through detection of residual tumor after resection, relapse, or metastasis within a particular patient.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Health & Fitness
Education
Science

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 8,170,536 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We can't tell how the site generates income.

Some websites aren't about earning revenue; they're built to connect communities or raise awareness. There are numerous motivations behind creating websites. This might be one of them. Link.springer.com has a secret sauce for making money, but we can't detect it yet.

Keywords {🔍}

cancer, breast, article, pubmed, google, scholar, cas, heterogeneity, tumor, evolution, clinical, dna, metastatic, circulating, nature, central, journal, clonal, metastasis, sequencing, medicine, progression, research, primary, odense, liquid, review, analysis, genetic, reviews, biopsy, plasma, treatment, tumour, cancers, oncology, plos, denmark, privacy, cookies, content, information, patients, kavan, disease, monitoring, landscape, biopsies, current, access,

Topics {✒️}

month download article/chapter powerful real-time approach tissue microarray-based study related subjects copy number aberrations hildebrandt & mads thomassen full article pdf intra-tumour heterogeneity single-cell genome sequencing positron emission tomography circulating tumour dna cell-free dna primary breast cancers metastatic breast cancer circulating tumor dna privacy choices/manage cookies measuring clonal evolution breast cancer research nature publishing grou human breast cancer advanced cancer patients overcome tumor heterogeneity branched evolution revealed staging breast cancer tumor mutation load pathologic tumour size article cancer tumor evolution reflected breast cancer progression breast cancer metastasis digital breast tomosynthesis monitoring clonal progression breast cancer resistance circulating tumor cells national cancer institute article kavan linear genome evolution clinical cancer research nature reviews cancer single nucleotide resolution circulating cancer cells current studies focusing treatment selection multiple intratumoral assays breast cancer recurrence review tumor heterogeneity single-cell sequencing multiregional tissue biopsies personalized response monitoring immunohistochemical marker expression

Questions {❓}

Intra-tumour heterogeneity: A looking glass for cancer?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Heterogeneity and tumor evolution reflected in liquid biopsy in metastatic breast cancer patients: a review
         description:Breast cancer is a spatially and temporally dynamic disease in which differently evolving genetic clones are responsible for progression and clinical outcome. We review tumor heterogeneity and clonal evolution from studies comparing primary tumors and metastasis and discuss plasma circulating tumor DNA as a powerful real-time approach for monitoring the clonal landscape of breast cancer during treatment and recurrence. We found only a few early studies exploring clonal evolution and heterogeneity through analysis of multiregional tissue biopsies of different progression steps in comparison with circulating tumor DNA (ctDNA) from blood plasma. The model of linear progression seemed to be more often reported than the model of parallel progression. The results show complex routes to metastasis, however, and plasma most often reflected metastasis more than primary tumor. The described patterns of evolution and the polyclonal nature of breast cancer have clinical consequences and should be considered during patient diagnosis and treatment selection. Current studies focusing on the relevance of clonal evolution in the clinical setting illustrate the role of liquid biopsy as a noninvasive biomarker for monitoring clonal progression and response to treatment. In the clinical setting, circulating tumor DNA may be an ideal support for tumor biopsies to characterize the genetic landscape of the metastatic disease and to improve longitudinal monitoring of disease dynamics and treatment effectiveness through detection of residual tumor after resection, relapse, or metastasis within a particular patient.
         datePublished:2022-03-14T00:00:00Z
         dateModified:2022-03-14T00:00:00Z
         pageStart:433
         pageEnd:446
         sameAs:https://doi.org/10.1007/s10555-022-10023-9
         keywords:
            Clonal evolution
            Tumor heterogeneity
            Breast cancer
            ctDNA
            Liquid biopsy
            Cancer Research
            Oncology
            Biomedicine
            general
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10555-022-10023-9/MediaObjects/10555_2022_10023_Fig1_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10555-022-10023-9/MediaObjects/10555_2022_10023_Fig2_HTML.png
         isPartOf:
            name:Cancer and Metastasis Reviews
            issn:
               1573-7233
               0167-7659
            volumeNumber:41
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer US
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Stephanie Kavan
               url:http://orcid.org/0000-0001-5272-2118
               affiliation:
                     name:Odense University Hospital
                     address:
                        name:Department of Clinical Genetics, Odense University Hospital, Odense, Denmark
                        type:PostalAddress
                     type:Organization
                     name:University of Southern Denmark
                     address:
                        name:Department of Clinical Research, University of Southern Denmark, Odense, Denmark
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Torben A. Kruse
               affiliation:
                     name:Odense University Hospital
                     address:
                        name:Department of Clinical Genetics, Odense University Hospital, Odense, Denmark
                        type:PostalAddress
                     type:Organization
                     name:University of Southern Denmark
                     address:
                        name:Department of Clinical Research, University of Southern Denmark, Odense, Denmark
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Marianne Vogsen
               affiliation:
                     name:University of Southern Denmark
                     address:
                        name:Department of Clinical Research, University of Southern Denmark, Odense, Denmark
                        type:PostalAddress
                     type:Organization
                     name:Odense University Hospital
                     address:
                        name:Department of Oncology, Odense University Hospital, Odense, Denmark
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Malene G. Hildebrandt
               affiliation:
                     name:University of Southern Denmark
                     address:
                        name:Department of Clinical Research, University of Southern Denmark, Odense, Denmark
                        type:PostalAddress
                     type:Organization
                     name:Odense University Hospital
                     address:
                        name:Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark
                        type:PostalAddress
                     type:Organization
                     name:Odense University Hospital
                     address:
                        name:Centre for Personalized Response Monitoring in Oncology (PREMIO), Odense University Hospital, Odense, Denmark
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Mads Thomassen
               affiliation:
                     name:Odense University Hospital
                     address:
                        name:Department of Clinical Genetics, Odense University Hospital, Odense, Denmark
                        type:PostalAddress
                     type:Organization
                     name:University of Southern Denmark
                     address:
                        name:Department of Clinical Research, University of Southern Denmark, Odense, Denmark
                        type:PostalAddress
                     type:Organization
                     name:Odense University Hospital
                     address:
                        name:Centre for Personalized Response Monitoring in Oncology (PREMIO), Odense University Hospital, Odense, Denmark
                        type:PostalAddress
                     type:Organization
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Heterogeneity and tumor evolution reflected in liquid biopsy in metastatic breast cancer patients: a review
      description:Breast cancer is a spatially and temporally dynamic disease in which differently evolving genetic clones are responsible for progression and clinical outcome. We review tumor heterogeneity and clonal evolution from studies comparing primary tumors and metastasis and discuss plasma circulating tumor DNA as a powerful real-time approach for monitoring the clonal landscape of breast cancer during treatment and recurrence. We found only a few early studies exploring clonal evolution and heterogeneity through analysis of multiregional tissue biopsies of different progression steps in comparison with circulating tumor DNA (ctDNA) from blood plasma. The model of linear progression seemed to be more often reported than the model of parallel progression. The results show complex routes to metastasis, however, and plasma most often reflected metastasis more than primary tumor. The described patterns of evolution and the polyclonal nature of breast cancer have clinical consequences and should be considered during patient diagnosis and treatment selection. Current studies focusing on the relevance of clonal evolution in the clinical setting illustrate the role of liquid biopsy as a noninvasive biomarker for monitoring clonal progression and response to treatment. In the clinical setting, circulating tumor DNA may be an ideal support for tumor biopsies to characterize the genetic landscape of the metastatic disease and to improve longitudinal monitoring of disease dynamics and treatment effectiveness through detection of residual tumor after resection, relapse, or metastasis within a particular patient.
      datePublished:2022-03-14T00:00:00Z
      dateModified:2022-03-14T00:00:00Z
      pageStart:433
      pageEnd:446
      sameAs:https://doi.org/10.1007/s10555-022-10023-9
      keywords:
         Clonal evolution
         Tumor heterogeneity
         Breast cancer
         ctDNA
         Liquid biopsy
         Cancer Research
         Oncology
         Biomedicine
         general
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10555-022-10023-9/MediaObjects/10555_2022_10023_Fig1_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10555-022-10023-9/MediaObjects/10555_2022_10023_Fig2_HTML.png
      isPartOf:
         name:Cancer and Metastasis Reviews
         issn:
            1573-7233
            0167-7659
         volumeNumber:41
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer US
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Stephanie Kavan
            url:http://orcid.org/0000-0001-5272-2118
            affiliation:
                  name:Odense University Hospital
                  address:
                     name:Department of Clinical Genetics, Odense University Hospital, Odense, Denmark
                     type:PostalAddress
                  type:Organization
                  name:University of Southern Denmark
                  address:
                     name:Department of Clinical Research, University of Southern Denmark, Odense, Denmark
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Torben A. Kruse
            affiliation:
                  name:Odense University Hospital
                  address:
                     name:Department of Clinical Genetics, Odense University Hospital, Odense, Denmark
                     type:PostalAddress
                  type:Organization
                  name:University of Southern Denmark
                  address:
                     name:Department of Clinical Research, University of Southern Denmark, Odense, Denmark
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Marianne Vogsen
            affiliation:
                  name:University of Southern Denmark
                  address:
                     name:Department of Clinical Research, University of Southern Denmark, Odense, Denmark
                     type:PostalAddress
                  type:Organization
                  name:Odense University Hospital
                  address:
                     name:Department of Oncology, Odense University Hospital, Odense, Denmark
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Malene G. Hildebrandt
            affiliation:
                  name:University of Southern Denmark
                  address:
                     name:Department of Clinical Research, University of Southern Denmark, Odense, Denmark
                     type:PostalAddress
                  type:Organization
                  name:Odense University Hospital
                  address:
                     name:Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark
                     type:PostalAddress
                  type:Organization
                  name:Odense University Hospital
                  address:
                     name:Centre for Personalized Response Monitoring in Oncology (PREMIO), Odense University Hospital, Odense, Denmark
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Mads Thomassen
            affiliation:
                  name:Odense University Hospital
                  address:
                     name:Department of Clinical Genetics, Odense University Hospital, Odense, Denmark
                     type:PostalAddress
                  type:Organization
                  name:University of Southern Denmark
                  address:
                     name:Department of Clinical Research, University of Southern Denmark, Odense, Denmark
                     type:PostalAddress
                  type:Organization
                  name:Odense University Hospital
                  address:
                     name:Centre for Personalized Response Monitoring in Oncology (PREMIO), Odense University Hospital, Odense, Denmark
                     type:PostalAddress
                  type:Organization
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Cancer and Metastasis Reviews
      issn:
         1573-7233
         0167-7659
      volumeNumber:41
Organization:
      name:Springer US
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Odense University Hospital
      address:
         name:Department of Clinical Genetics, Odense University Hospital, Odense, Denmark
         type:PostalAddress
      name:University of Southern Denmark
      address:
         name:Department of Clinical Research, University of Southern Denmark, Odense, Denmark
         type:PostalAddress
      name:Odense University Hospital
      address:
         name:Department of Clinical Genetics, Odense University Hospital, Odense, Denmark
         type:PostalAddress
      name:University of Southern Denmark
      address:
         name:Department of Clinical Research, University of Southern Denmark, Odense, Denmark
         type:PostalAddress
      name:University of Southern Denmark
      address:
         name:Department of Clinical Research, University of Southern Denmark, Odense, Denmark
         type:PostalAddress
      name:Odense University Hospital
      address:
         name:Department of Oncology, Odense University Hospital, Odense, Denmark
         type:PostalAddress
      name:University of Southern Denmark
      address:
         name:Department of Clinical Research, University of Southern Denmark, Odense, Denmark
         type:PostalAddress
      name:Odense University Hospital
      address:
         name:Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark
         type:PostalAddress
      name:Odense University Hospital
      address:
         name:Centre for Personalized Response Monitoring in Oncology (PREMIO), Odense University Hospital, Odense, Denmark
         type:PostalAddress
      name:Odense University Hospital
      address:
         name:Department of Clinical Genetics, Odense University Hospital, Odense, Denmark
         type:PostalAddress
      name:University of Southern Denmark
      address:
         name:Department of Clinical Research, University of Southern Denmark, Odense, Denmark
         type:PostalAddress
      name:Odense University Hospital
      address:
         name:Centre for Personalized Response Monitoring in Oncology (PREMIO), Odense University Hospital, Odense, Denmark
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Stephanie Kavan
      url:http://orcid.org/0000-0001-5272-2118
      affiliation:
            name:Odense University Hospital
            address:
               name:Department of Clinical Genetics, Odense University Hospital, Odense, Denmark
               type:PostalAddress
            type:Organization
            name:University of Southern Denmark
            address:
               name:Department of Clinical Research, University of Southern Denmark, Odense, Denmark
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Torben A. Kruse
      affiliation:
            name:Odense University Hospital
            address:
               name:Department of Clinical Genetics, Odense University Hospital, Odense, Denmark
               type:PostalAddress
            type:Organization
            name:University of Southern Denmark
            address:
               name:Department of Clinical Research, University of Southern Denmark, Odense, Denmark
               type:PostalAddress
            type:Organization
      name:Marianne Vogsen
      affiliation:
            name:University of Southern Denmark
            address:
               name:Department of Clinical Research, University of Southern Denmark, Odense, Denmark
               type:PostalAddress
            type:Organization
            name:Odense University Hospital
            address:
               name:Department of Oncology, Odense University Hospital, Odense, Denmark
               type:PostalAddress
            type:Organization
      name:Malene G. Hildebrandt
      affiliation:
            name:University of Southern Denmark
            address:
               name:Department of Clinical Research, University of Southern Denmark, Odense, Denmark
               type:PostalAddress
            type:Organization
            name:Odense University Hospital
            address:
               name:Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark
               type:PostalAddress
            type:Organization
            name:Odense University Hospital
            address:
               name:Centre for Personalized Response Monitoring in Oncology (PREMIO), Odense University Hospital, Odense, Denmark
               type:PostalAddress
            type:Organization
      name:Mads Thomassen
      affiliation:
            name:Odense University Hospital
            address:
               name:Department of Clinical Genetics, Odense University Hospital, Odense, Denmark
               type:PostalAddress
            type:Organization
            name:University of Southern Denmark
            address:
               name:Department of Clinical Research, University of Southern Denmark, Odense, Denmark
               type:PostalAddress
            type:Organization
            name:Odense University Hospital
            address:
               name:Centre for Personalized Response Monitoring in Oncology (PREMIO), Odense University Hospital, Odense, Denmark
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Department of Clinical Genetics, Odense University Hospital, Odense, Denmark
      name:Department of Clinical Research, University of Southern Denmark, Odense, Denmark
      name:Department of Clinical Genetics, Odense University Hospital, Odense, Denmark
      name:Department of Clinical Research, University of Southern Denmark, Odense, Denmark
      name:Department of Clinical Research, University of Southern Denmark, Odense, Denmark
      name:Department of Oncology, Odense University Hospital, Odense, Denmark
      name:Department of Clinical Research, University of Southern Denmark, Odense, Denmark
      name:Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark
      name:Centre for Personalized Response Monitoring in Oncology (PREMIO), Odense University Hospital, Odense, Denmark
      name:Department of Clinical Genetics, Odense University Hospital, Odense, Denmark
      name:Department of Clinical Research, University of Southern Denmark, Odense, Denmark
      name:Centre for Personalized Response Monitoring in Oncology (PREMIO), Odense University Hospital, Odense, Denmark
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(217)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.34s.

LINK . SPRINGER . COM {}