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We began analyzing https://link.springer.com/article/10.1007/s10555-021-09968-0, but it redirected us to https://link.springer.com/article/10.1007/s10555-021-09968-0. The analysis below is for the second page.

Title[redir]:
Prognostic and therapeutic role of tumor-infiltrating lymphocyte subtypes in breast cancer | Cancer and Metastasis Reviews
Description:
Increased levels of total tumor-infiltrating lymphocytes (TILs) are generally associated with good prognosis in several breast cancer subtypes. Subtypes of TILs impact both tumor cells and immune cells in a variety of different ways, leading to either a pro-tumor or antitumor effect. Tumor-infiltrating CD8+ T cells and natural killer (NK) cells perform as effector cells against tumor cells and are associated with better clinical outcome. Immunotherapy approaches that improve the antitumor activity and proliferation of CD8+ T and NK cells include PD-1/PD-L1 blockade, CAR T cell therapy, or ex vivo-stimulated NK cells. A subset of CD8+ T cells, tissue-resident memory T cells, has also recently been associated with good prognosis in breast cancer patients, and has potential to serve as a predictive biomarker and therapeutic target. Tumor-infiltrating B cells also secrete apoptosis-inducing IgG antibodies and can act as antigen-presenting cells to prime CD4+ and CD8+ T cells. On the other hand, regulatory T and regulatory B cells modulate the immune response from CD8+ T cells and NK cells by secreting immunosuppressive cytokines and inhibiting maturation of antigen-presenting cells (APCs). These regulatory cells are typically associated with poor prognosis, therefore rendering suppression of their regulatory function a key immunotherapeutic strategy.

Matching Content Categories {📚}

  • Science
  • Health & Fitness
  • Education

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

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Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


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How Does Doi.org Make Money? {💸}

We don't see any clear sign of profit-making.

Not every website is profit-driven; some are created to spread information or serve as an online presence. Websites can be made for many reasons. This could be one of them. Doi.org could be secretly minting cash, but we can't detect the process.

Keywords {🔍}

pubmed, article, google, scholar, cancer, cas, cells, breast, central, cell, patients, regulatory, journal, research, httpsdoiorgs, tumor, immunol, lymphocytes, clinical, tumorinfiltrating, immunology, natural, oncology, immune, memory, nature, human, killer, prognostic, response, phase, res, expression, wang, interleukin, study, metastatic, triplenegative, dendritic, med, lee, prognosis, immunotherapy, therapy, immunity, treatment, function, chemotherapy, httpsdoiorgjimmunol, antigen,

Topics {✒️}

fda%20grants%20accelerated%20approval%20to%20pembrolizumab%20for%20locally%20recurrent databases/fda-grants-accelerated-approval-pembrolizumab-locally-recurrent-unresectable metastatic%20triple%20negative%20breast%20cancer&text= p53-peptide-pulsed dendritic cells anti–pd-1/pd-l1 therapy anti-pd-l1 antibody avelumab month download article/chapter pd-l1 + tumor-infiltrating lymphocytes her2/neu-expressing malignancies t-cell metagene predicts tumors express pd-l1 anti-pd-l1 therapy anti-pd-l1 antibody triple-negative breast cancers her2-positive breast cancers tumor-induced composite subsets text=approvals%20and%20databases tumor-specific tissue-resident memory chimeric antigen receptor-modified anti-cd3/cd28 promotes triple-negative breast cancer natural killer-mediated cytotoxicity node-negative breast cancer pd-l1 expression correlates tumor-draining lymph nodes %20november%2013%2c%202020%2c%20the keytruda%2c%20merck%20%26%20co h-2-deficient lymphoma variants pd-l1-blockade resistance cd8+cd103+ tumor-infiltrating lymphocytes cd8+ t-cell infiltration locally recurrent unresectable versus single-agent chemotherapy 2/neu protein-specific antibody human nk-cell cytokine gov/drugs/drug-approvals β-d-mannuronic acid writing—original draft preparation breast cancer—adverse events phospholipase cgamma-dependent pathway tumor-infiltrating lymphocyte aggregates forkhead/winged-helix protein double-negative breast cancer tumor-infiltrating human cd4 her2-specific therapeutic antibodies early-stage breast cancer regulatory t-cell function human tissue-resident memory long-lived plasma cell synergistically increase il-10-producing

Questions {❓}

  • Regulatory T (Treg) cells in cancer: Can Treg cells be a new therapeutic target?

Schema {🗺️}

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         headline:Prognostic and therapeutic role of tumor-infiltrating lymphocyte subtypes in breast cancer
         description:Increased levels of total tumor-infiltrating lymphocytes (TILs) are generally associated with good prognosis in several breast cancer subtypes. Subtypes of TILs impact both tumor cells and immune cells in a variety of different ways, leading to either a pro-tumor or antitumor effect. Tumor-infiltrating CD8+ T cells and natural killer (NK) cells perform as effector cells against tumor cells and are associated with better clinical outcome. Immunotherapy approaches that improve the antitumor activity and proliferation of CD8+ T and NK cells include PD-1/PD-L1 blockade, CAR T cell therapy, or ex vivo-stimulated NK cells. A subset of CD8+ T cells, tissue-resident memory T cells, has also recently been associated with good prognosis in breast cancer patients, and has potential to serve as a predictive biomarker and therapeutic target. Tumor-infiltrating B cells also secrete apoptosis-inducing IgG antibodies and can act as antigen-presenting cells to prime CD4+ and CD8+ T cells. On the other hand, regulatory T and regulatory B cells modulate the immune response from CD8+ T cells and NK cells by secreting immunosuppressive cytokines and inhibiting maturation of antigen-presenting cells (APCs). These regulatory cells are typically associated with poor prognosis, therefore rendering suppression of their regulatory function a key immunotherapeutic strategy.
         datePublished:2021-05-07T00:00:00Z
         dateModified:2021-05-07T00:00:00Z
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            Cancer Research
            Oncology
            Biomedicine
            general
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      headline:Prognostic and therapeutic role of tumor-infiltrating lymphocyte subtypes in breast cancer
      description:Increased levels of total tumor-infiltrating lymphocytes (TILs) are generally associated with good prognosis in several breast cancer subtypes. Subtypes of TILs impact both tumor cells and immune cells in a variety of different ways, leading to either a pro-tumor or antitumor effect. Tumor-infiltrating CD8+ T cells and natural killer (NK) cells perform as effector cells against tumor cells and are associated with better clinical outcome. Immunotherapy approaches that improve the antitumor activity and proliferation of CD8+ T and NK cells include PD-1/PD-L1 blockade, CAR T cell therapy, or ex vivo-stimulated NK cells. A subset of CD8+ T cells, tissue-resident memory T cells, has also recently been associated with good prognosis in breast cancer patients, and has potential to serve as a predictive biomarker and therapeutic target. Tumor-infiltrating B cells also secrete apoptosis-inducing IgG antibodies and can act as antigen-presenting cells to prime CD4+ and CD8+ T cells. On the other hand, regulatory T and regulatory B cells modulate the immune response from CD8+ T cells and NK cells by secreting immunosuppressive cytokines and inhibiting maturation of antigen-presenting cells (APCs). These regulatory cells are typically associated with poor prognosis, therefore rendering suppression of their regulatory function a key immunotherapeutic strategy.
      datePublished:2021-05-07T00:00:00Z
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         Immunotherapy
         Tumor microenvironment
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         Cancer Research
         Oncology
         Biomedicine
         general
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      name:Shiuh-Wen Luoh
      affiliation:
            name:VA Portland Health Care System, Knight Cancer Institute, Oregon Health and Science University
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               name:VA Portland Health Care System, Knight Cancer Institute, Oregon Health and Science University, Portland, USA
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