We are analyzing https://link.springer.com/article/10.1007/s12253-015-0024-7.

Title:
Prognostic Factors for Breast Cancer: an Immunomorphological Update | Pathology & Oncology Research
Description:
The prognostic variability recorded within homogeneous groups of patients for anatomo-clinical disease stages has led to a more detailed biological characterization of breast cancer. Recently, the attention of the scientific community has focused on the role of tumor-infiltrating lymphocytes (TILs). Therefore, the need of an in-depth immunomorphological characterization of TILs has been emerged. The presence of TILs has been retrospectively investigated in 113 female cases of ductal carcinoma. An immunohistochemical investigation with CD3, CD4, CD8, CD20, CD56, granulysin, perforin-1, granzyme-B and TIA-1 was performed according to the standard procedures on all 17 cases with TILs evidence. TILs consisted of T and B lymphocytes: the prevalent population showed a T immunoprofile with a CD8-immunopositive killer subpopulation (Tk), close-linked to carcinomatous cells, and a CD4-immunopositive helper subpopulation (Th), inside the tumor. A time sequence (firstly T, then B) has been disclosed. Granulysin, perforin, granzyme-B and TIA-1 were expressed by Tk cells. The activated Tk cells secrete these mediators as a result of the binding to the tumor target cell, causing its lytic planned death. The cytotoxicity supported by Tk cells appears an important favorable prognostic factor. Therefore, a graduation system for TILs in breast cancer has been here proposed (absent, non-brisk, brisk).
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Keywords {🔍}

cancer, article, breast, pubmed, google, scholar, lymphocytes, prognostic, cas, tumorinfiltrating, tumor, roncati, tils, cells, central, research, privacy, cookies, content, barbolini, access, infiltrating, health, publish, search, pathology, luca, primary, predictive, modena, data, information, log, journal, oncology, factors, immunomorphological, november, piacentini, disease, ductal, carcinoma, granulysin, tia, cell, factor, response, chapter, discover, cytotoxic,

Topics {✒️}

fas-activated serine/threonine kinase tumour-infiltrating cd8+ lymphocytes month download article/chapter triple-negative breast cancer francesco piscioli & teresa pusiol small-cell lung cancer node-negative breast cancer cd8-immunopositive killer subpopulation cd4-immunopositive helper subpopulation tumor-infiltrating immune cells anatomo-clinical disease stages jak2/stat4/perforin pathway breast tumor growth full article pdf tumor-infiltrating lymphocytes tumor infiltrating lymphocytes tumor target cell prognostic factors independent predictive factor privacy choices/manage cookies early breast cancer breast cancer treated breast cancer subtypes human breast cancer favorable prognostic marker primary systemic therapy prognostic variability recorded fas-mediated apoptosis invasive tumor front infiltrating ductal carcinoma article roncati depth immunomorphological characterization european economic area detailed biological characterization prevalent population showed lytic planned death related subjects evaluating jak2 inhibitors cryptotanshinone induces inhibition ethics declarations funding conditions privacy policy cytotoxic cd4+ article log tk cells appears neoadjuvant systemic therapy breast cancer accepting optional cookies pathological complete response federico piacentini article cite

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         headline:Prognostic Factors for Breast Cancer: an Immunomorphological Update
         description:The prognostic variability recorded within homogeneous groups of patients for anatomo-clinical disease stages has led to a more detailed biological characterization of breast cancer. Recently, the attention of the scientific community has focused on the role of tumor-infiltrating lymphocytes (TILs). Therefore, the need of an in-depth immunomorphological characterization of TILs has been emerged. The presence of TILs has been retrospectively investigated in 113 female cases of ductal carcinoma. An immunohistochemical investigation with CD3, CD4, CD8, CD20, CD56, granulysin, perforin-1, granzyme-B and TIA-1 was performed according to the standard procedures on all 17 cases with TILs evidence. TILs consisted of T and B lymphocytes: the prevalent population showed a T immunoprofile with a CD8-immunopositive killer subpopulation (Tk), close-linked to carcinomatous cells, and a CD4-immunopositive helper subpopulation (Th), inside the tumor. A time sequence (firstly T, then B) has been disclosed. Granulysin, perforin, granzyme-B and TIA-1 were expressed by Tk cells. The activated Tk cells secrete these mediators as a result of the binding to the tumor target cell, causing its lytic planned death. The cytotoxicity supported by Tk cells appears an important favorable prognostic factor. Therefore, a graduation system for TILs in breast cancer has been here proposed (absent, non-brisk, brisk).
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            Prognostic factors
            Histology
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            Oncology
            Pathology
            Immunology
            Biomedicine
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      headline:Prognostic Factors for Breast Cancer: an Immunomorphological Update
      description:The prognostic variability recorded within homogeneous groups of patients for anatomo-clinical disease stages has led to a more detailed biological characterization of breast cancer. Recently, the attention of the scientific community has focused on the role of tumor-infiltrating lymphocytes (TILs). Therefore, the need of an in-depth immunomorphological characterization of TILs has been emerged. The presence of TILs has been retrospectively investigated in 113 female cases of ductal carcinoma. An immunohistochemical investigation with CD3, CD4, CD8, CD20, CD56, granulysin, perforin-1, granzyme-B and TIA-1 was performed according to the standard procedures on all 17 cases with TILs evidence. TILs consisted of T and B lymphocytes: the prevalent population showed a T immunoprofile with a CD8-immunopositive killer subpopulation (Tk), close-linked to carcinomatous cells, and a CD4-immunopositive helper subpopulation (Th), inside the tumor. A time sequence (firstly T, then B) has been disclosed. Granulysin, perforin, granzyme-B and TIA-1 were expressed by Tk cells. The activated Tk cells secrete these mediators as a result of the binding to the tumor target cell, causing its lytic planned death. The cytotoxicity supported by Tk cells appears an important favorable prognostic factor. Therefore, a graduation system for TILs in breast cancer has been here proposed (absent, non-brisk, brisk).
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      dateModified:2015-11-20T00:00:00Z
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         Prognostic factors
         Histology
         Immunohistochemistry
         Tumor-infiltrating lymphocytes (TILs)
         Granulysin
         Cancer Research
         Oncology
         Pathology
         Immunology
         Biomedicine
         general
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