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Title[redir]:
TFAP2E hypermethylation was associated with survival advantage in patients with colorectal cancer | Journal of Cancer Research and Clinical Oncology
Description:
Hypermethylation of TFAP2E (AP-2E) is associated with the chemotherapy-resistant in patients with colorectal cancer (CRC), but its implications on prognosis directly remain unknown. This study was aimed to investigate the role of AP-2E methylation status and other clinicopathologic parameters as predictors of prognosis. We detected the methylation status of AP-2E in tumor and adjacent non-tumor tissues from 311 sporadic CRC patients by methylation-sensitive high-resolution melting analysis. Log-rank tests and multivariate Cox analyses were performed to evaluate the role of AP-2E methylation status and other clinicopathologic parameters as predictors of prognosis. Hypermethylation of AP-2E was detected in 61 % (190/311) tumor tissues. It occurred more frequently in tumors in earlier stages (I/II; P = 0.02), lower levels of tumor invasion (T1āT3; P = 0.04), fewer lymph nodes involved (N0; P < 0.01), and higher histologic grades (G1/G2; P < 0.01). The overall 5-year survival rates in hypermethylation and hypomethylation group were 76.91 and 47.17 % (P < 0.0001), respectively. AP-2E hypermethylation was significantly associated with a favorable clinical outcome with a hazard ratio of 0.486 (95 % CI 0.342ā0.692, P < 0.0001) after controlling for age, gender, tumor location, histologic type, TNM staging, and histologic grade. AP-2E was frequently hypermethylated in tumors from patients with CRC. Aberrant hypermethylation of AP-2E occurred more frequently in tumors with earlier stages, lower levels of tumor invasion, fewer lymph nodes involved, and higher histologic grades. AP-2E hypermethylation might be an independent predictor of survival advantage in patients with CRC.
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Keywords {š}
cancer, pubmed, article, google, scholar, cas, colorectal, methylation, central, hypermethylation, survival, ape, patients, dna, wang, tumor, transcription, zhang, access, gene, privacy, cookies, content, journal, research, clinical, zhao, prognosis, breast, expression, oncol, publish, search, tfape, xia, lin, yashuang, crc, status, histologic, factor, cell, chen, resistance, mol, china, harbin, data, information, log,
Topics {āļø}
methylation-sensitive high-resolution melting month download article/chapter transcription factor ap-2alpha ya-shuang zhao large population-based sample methylation-induced repressionābelts egfr-targeted monoclonal antibodies bin-bin cui ap-2e methylation status related subjects full article pdf dna methylation biomarkers aberrant dna methylation mouse skin cancers clinical oncology aims unbiased methylation profiling privacy choices/manage cookies breast cancer cells ap-2 transcription factors colorectal cancers advanced bladder cancer genome-wide screening epithelial ovarian cancer global cancer statistics nhs cancer plan favorable clinical outcome dna methylation lymph node metastasis gastric adenocarcinoma prognosis genomic biomarker discovery p53 mutation status cell-cycle control conclusions ap-2e ap-2e hypermethylation european economic area fu-lan hu multivariate cox analyses 5-year survival rates reinacher-schick ac chronic myelogenous leukemia sartore-bianchi brca1 interactor srbc article zhang hmlh1 promoter hypermethylation article log prostate cancer cells conditions privacy policy colorectal cancer breast cancer breast cancer
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headline:TFAP2E hypermethylation was associated with survival advantage in patients with colorectal cancer
description:Hypermethylation of TFAP2E (AP-2E) is associated with the chemotherapy-resistant in patients with colorectal cancer (CRC), but its implications on prognosis directly remain unknown. This study was aimed to investigate the role of AP-2E methylation status and other clinicopathologic parameters as predictors of prognosis. We detected the methylation status of AP-2E in tumor and adjacent non-tumor tissues from 311 sporadic CRC patients by methylation-sensitive high-resolution melting analysis. Log-rank tests and multivariate Cox analyses were performed to evaluate the role of AP-2E methylation status and other clinicopathologic parameters as predictors of prognosis. Hypermethylation of AP-2E was detected in 61Ā % (190/311) tumor tissues. It occurred more frequently in tumors in earlier stages (I/II; PĀ =Ā 0.02), lower levels of tumor invasion (T1āT3; PĀ =Ā 0.04), fewer lymph nodes involved (N0; PĀ <Ā 0.01), and higher histologic grades (G1/G2; PĀ <Ā 0.01). The overall 5-year survival rates in hypermethylation and hypomethylation group were 76.91 and 47.17Ā % (PĀ <Ā 0.0001), respectively. AP-2E hypermethylation was significantly associated with a favorable clinical outcome with a hazard ratio of 0.486 (95Ā % CI 0.342ā0.692, PĀ <Ā 0.0001) after controlling for age, gender, tumor location, histologic type, TNM staging, and histologic grade. AP-2E was frequently hypermethylated in tumors from patients with CRC. Aberrant hypermethylation of AP-2E occurred more frequently in tumors with earlier stages, lower levels of tumor invasion, fewer lymph nodes involved, and higher histologic grades. AP-2E hypermethylation might be an independent predictor of survival advantage in patients with CRC.
datePublished:2014-07-06T00:00:00Z
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Colorectal cancer
TFAP2E
DNA methylation
Prognosis
Oncology
Cancer Research
Internal Medicine
Hematology
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headline:TFAP2E hypermethylation was associated with survival advantage in patients with colorectal cancer
description:Hypermethylation of TFAP2E (AP-2E) is associated with the chemotherapy-resistant in patients with colorectal cancer (CRC), but its implications on prognosis directly remain unknown. This study was aimed to investigate the role of AP-2E methylation status and other clinicopathologic parameters as predictors of prognosis. We detected the methylation status of AP-2E in tumor and adjacent non-tumor tissues from 311 sporadic CRC patients by methylation-sensitive high-resolution melting analysis. Log-rank tests and multivariate Cox analyses were performed to evaluate the role of AP-2E methylation status and other clinicopathologic parameters as predictors of prognosis. Hypermethylation of AP-2E was detected in 61Ā % (190/311) tumor tissues. It occurred more frequently in tumors in earlier stages (I/II; PĀ =Ā 0.02), lower levels of tumor invasion (T1āT3; PĀ =Ā 0.04), fewer lymph nodes involved (N0; PĀ <Ā 0.01), and higher histologic grades (G1/G2; PĀ <Ā 0.01). The overall 5-year survival rates in hypermethylation and hypomethylation group were 76.91 and 47.17Ā % (PĀ <Ā 0.0001), respectively. AP-2E hypermethylation was significantly associated with a favorable clinical outcome with a hazard ratio of 0.486 (95Ā % CI 0.342ā0.692, PĀ <Ā 0.0001) after controlling for age, gender, tumor location, histologic type, TNM staging, and histologic grade. AP-2E was frequently hypermethylated in tumors from patients with CRC. Aberrant hypermethylation of AP-2E occurred more frequently in tumors with earlier stages, lower levels of tumor invasion, fewer lymph nodes involved, and higher histologic grades. AP-2E hypermethylation might be an independent predictor of survival advantage in patients with CRC.
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Colorectal cancer
TFAP2E
DNA methylation
Prognosis
Oncology
Cancer Research
Internal Medicine
Hematology
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