We are analyzing https://link.springer.com/article/10.1186/gb-2005-6-13-246.

Title:
The AP-2 family of transcription factors | Genome Biology
Description:
The AP-2 family of transcription factors consists of five different proteins in humans and mice: AP-2α, AP-2β, AP-2γ, AP-2δ and AP-2ε. Frogs and fish have known orthologs of some but not all of these proteins, and homologs of the family are also found in protochordates, insects and nematodes. The proteins have a characteristic helix-span-helix motif at the carboxyl terminus, which, together with a central basic region, mediates dimerization and DNA binding. The amino terminus contains the transactivation domain. AP-2 proteins are first expressed in primitive ectoderm of invertebrates and vertebrates; in vertebrates, they are also expressed in the emerging neural-crest cells, and AP-2α -/- animals have impairments in neural-crest-derived facial structures. AP-2β is indispensable for kidney development and AP-2γ is necessary for the formation of trophectoderm cells shortly after implantation; AP-2α and AP-2γ levels are elevated in human mammary carcinoma and seminoma. The general functions of the family appear to be the cell-type-specific stimulation of proliferation and the suppression of terminal differentiation during embryonic development.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Science
Education
Video & Online Content

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 7,642,828 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We see no obvious way the site makes money.

While many websites aim to make money, others are created to share knowledge or showcase creativity. People build websites for various reasons. This could be one of them. Link.springer.com has a revenue plan, but it's either invisible or we haven't found it.

Keywords {🔍}

pubmed, google, scholar, article, cas, transcription, factor, proteins, development, gene, family, expression, cancer, biol, central, factors, genes, dev, protein, apα, cell, williams, binding, neural, schorle, cells, apalpha, apδ, xenopus, chem, res, apβ, expressed, human, crest, apγ, domain, motif, dna, zebrafish, acids, jbcm, mol, hurst, breast, transactivation, table, figure, target, apgamma,

Topics {✒️}

adenomatous polyposis coli/beta-catenin dominant negative allele richard jäger & hubert schorle characteristic helix-span-helix motif online mendelian inheritance p300/creb-binding protein helix-span-helix motif neural-crest-derived facial structures erbb-2-induced mammary tumorigenesis ap-2-mediated transcriptional activation sumo-conjugating enzyme ubc9 cell-type-specific stimulation transcription factor ap-2alpha cre/loxp recombination system ap-2gamma transcription factor transcription factor ap-2gamma emerging neural-crest cells hetero-dimeric complexes bound wnt1-cre-mediated deletion enhancer-binding protein ap-2 /c-rich elements heterologous dna-binding proteins binding-site selection assay central basic region ligand-bound oestrogen receptor frontonasal process-specific disruption c-myc activate expression central nervous system conserved ap-2-binding sites full size image hamster histone h3 ap-2α/γ targets ap-2α predominantly affects limb mesenchyme amino-acid sequence alignments adenomatous polyposis coli db=omim] zhao mediates dna binding mammalian ap-2α proteins enhancer-dependent transcription murine breast-cancer model references hilger-eversheim transcription factor ap2 ap-2 transcription factor transcription factor ap-2 privacy choices/manage cookies tumor suppressor protein neural-crest cells transcription factors pax6 transcription factors ap2

Questions {❓}

Schema {🗺️}

WebPage:
      mainEntity:
         headline:The AP-2 family of transcription factors
         description:The AP-2 family of transcription factors consists of five different proteins in humans and mice: AP-2α, AP-2β, AP-2γ, AP-2δ and AP-2ε. Frogs and fish have known orthologs of some but not all of these proteins, and homologs of the family are also found in protochordates, insects and nematodes. The proteins have a characteristic helix-span-helix motif at the carboxyl terminus, which, together with a central basic region, mediates dimerization and DNA binding. The amino terminus contains the transactivation domain. AP-2 proteins are first expressed in primitive ectoderm of invertebrates and vertebrates; in vertebrates, they are also expressed in the emerging neural-crest cells, and AP-2α -/- animals have impairments in neural-crest-derived facial structures. AP-2β is indispensable for kidney development and AP-2γ is necessary for the formation of trophectoderm cells shortly after implantation; AP-2α and AP-2γ levels are elevated in human mammary carcinoma and seminoma. The general functions of the family appear to be the cell-type-specific stimulation of proliferation and the suppression of terminal differentiation during embryonic development.
         datePublished:2005-12-28T00:00:00Z
         dateModified:2005-12-28T00:00:00Z
         pageStart:1
         pageEnd:8
         sameAs:https://doi.org/10.1186/gb-2005-6-13-246
         keywords:
            Neural Crest
            Limb Mesenchyme
            Primitive Ectoderm
            Dominant Negative Allele
            Genome Assembly Database
            Animal Genetics and Genomics
            Human Genetics
            Plant Genetics and Genomics
            Microbial Genetics and Genomics
            Bioinformatics
            Evolutionary Biology
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fgb-2005-6-13-246/MediaObjects/13059_2005_Article_990_Fig1_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fgb-2005-6-13-246/MediaObjects/13059_2005_Article_990_Fig2_HTML.jpg
         isPartOf:
            name:Genome Biology
            issn:
               1474-760X
            volumeNumber:6
            type:
               Periodical
               PublicationVolume
         publisher:
            name:BioMed Central
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Dawid Eckert
               affiliation:
                     name:Department of Developmental Pathology, Institute of Pathology
                     address:
                        name:Department of Developmental Pathology, Institute of Pathology, Bonn, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Sandra Buhl
               affiliation:
                     name:Department of Developmental Pathology, Institute of Pathology
                     address:
                        name:Department of Developmental Pathology, Institute of Pathology, Bonn, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Susanne Weber
               affiliation:
                     name:Department of Developmental Pathology, Institute of Pathology
                     address:
                        name:Department of Developmental Pathology, Institute of Pathology, Bonn, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Richard Jäger
               affiliation:
                     name:Department of Developmental Pathology, Institute of Pathology
                     address:
                        name:Department of Developmental Pathology, Institute of Pathology, Bonn, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Hubert Schorle
               affiliation:
                     name:Department of Developmental Pathology, Institute of Pathology
                     address:
                        name:Department of Developmental Pathology, Institute of Pathology, Bonn, Germany
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:The AP-2 family of transcription factors
      description:The AP-2 family of transcription factors consists of five different proteins in humans and mice: AP-2α, AP-2β, AP-2γ, AP-2δ and AP-2ε. Frogs and fish have known orthologs of some but not all of these proteins, and homologs of the family are also found in protochordates, insects and nematodes. The proteins have a characteristic helix-span-helix motif at the carboxyl terminus, which, together with a central basic region, mediates dimerization and DNA binding. The amino terminus contains the transactivation domain. AP-2 proteins are first expressed in primitive ectoderm of invertebrates and vertebrates; in vertebrates, they are also expressed in the emerging neural-crest cells, and AP-2α -/- animals have impairments in neural-crest-derived facial structures. AP-2β is indispensable for kidney development and AP-2γ is necessary for the formation of trophectoderm cells shortly after implantation; AP-2α and AP-2γ levels are elevated in human mammary carcinoma and seminoma. The general functions of the family appear to be the cell-type-specific stimulation of proliferation and the suppression of terminal differentiation during embryonic development.
      datePublished:2005-12-28T00:00:00Z
      dateModified:2005-12-28T00:00:00Z
      pageStart:1
      pageEnd:8
      sameAs:https://doi.org/10.1186/gb-2005-6-13-246
      keywords:
         Neural Crest
         Limb Mesenchyme
         Primitive Ectoderm
         Dominant Negative Allele
         Genome Assembly Database
         Animal Genetics and Genomics
         Human Genetics
         Plant Genetics and Genomics
         Microbial Genetics and Genomics
         Bioinformatics
         Evolutionary Biology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fgb-2005-6-13-246/MediaObjects/13059_2005_Article_990_Fig1_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fgb-2005-6-13-246/MediaObjects/13059_2005_Article_990_Fig2_HTML.jpg
      isPartOf:
         name:Genome Biology
         issn:
            1474-760X
         volumeNumber:6
         type:
            Periodical
            PublicationVolume
      publisher:
         name:BioMed Central
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Dawid Eckert
            affiliation:
                  name:Department of Developmental Pathology, Institute of Pathology
                  address:
                     name:Department of Developmental Pathology, Institute of Pathology, Bonn, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Sandra Buhl
            affiliation:
                  name:Department of Developmental Pathology, Institute of Pathology
                  address:
                     name:Department of Developmental Pathology, Institute of Pathology, Bonn, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Susanne Weber
            affiliation:
                  name:Department of Developmental Pathology, Institute of Pathology
                  address:
                     name:Department of Developmental Pathology, Institute of Pathology, Bonn, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Richard Jäger
            affiliation:
                  name:Department of Developmental Pathology, Institute of Pathology
                  address:
                     name:Department of Developmental Pathology, Institute of Pathology, Bonn, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Hubert Schorle
            affiliation:
                  name:Department of Developmental Pathology, Institute of Pathology
                  address:
                     name:Department of Developmental Pathology, Institute of Pathology, Bonn, Germany
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Genome Biology
      issn:
         1474-760X
      volumeNumber:6
Organization:
      name:BioMed Central
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Department of Developmental Pathology, Institute of Pathology
      address:
         name:Department of Developmental Pathology, Institute of Pathology, Bonn, Germany
         type:PostalAddress
      name:Department of Developmental Pathology, Institute of Pathology
      address:
         name:Department of Developmental Pathology, Institute of Pathology, Bonn, Germany
         type:PostalAddress
      name:Department of Developmental Pathology, Institute of Pathology
      address:
         name:Department of Developmental Pathology, Institute of Pathology, Bonn, Germany
         type:PostalAddress
      name:Department of Developmental Pathology, Institute of Pathology
      address:
         name:Department of Developmental Pathology, Institute of Pathology, Bonn, Germany
         type:PostalAddress
      name:Department of Developmental Pathology, Institute of Pathology
      address:
         name:Department of Developmental Pathology, Institute of Pathology, Bonn, Germany
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Dawid Eckert
      affiliation:
            name:Department of Developmental Pathology, Institute of Pathology
            address:
               name:Department of Developmental Pathology, Institute of Pathology, Bonn, Germany
               type:PostalAddress
            type:Organization
      name:Sandra Buhl
      affiliation:
            name:Department of Developmental Pathology, Institute of Pathology
            address:
               name:Department of Developmental Pathology, Institute of Pathology, Bonn, Germany
               type:PostalAddress
            type:Organization
      name:Susanne Weber
      affiliation:
            name:Department of Developmental Pathology, Institute of Pathology
            address:
               name:Department of Developmental Pathology, Institute of Pathology, Bonn, Germany
               type:PostalAddress
            type:Organization
      name:Richard Jäger
      affiliation:
            name:Department of Developmental Pathology, Institute of Pathology
            address:
               name:Department of Developmental Pathology, Institute of Pathology, Bonn, Germany
               type:PostalAddress
            type:Organization
      name:Hubert Schorle
      affiliation:
            name:Department of Developmental Pathology, Institute of Pathology
            address:
               name:Department of Developmental Pathology, Institute of Pathology, Bonn, Germany
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Developmental Pathology, Institute of Pathology, Bonn, Germany
      name:Department of Developmental Pathology, Institute of Pathology, Bonn, Germany
      name:Department of Developmental Pathology, Institute of Pathology, Bonn, Germany
      name:Department of Developmental Pathology, Institute of Pathology, Bonn, Germany
      name:Department of Developmental Pathology, Institute of Pathology, Bonn, Germany

External Links {🔗}(277)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.8s.

LINK . SPRINGER . COM {}