We are analyzing https://link.springer.com/article/10.1007/s00109-013-1088-z.

Title:
DNA methylation biomarkers as diagnostic and prognostic tools in colorectal cancer | Journal of Molecular Medicine
Description:
Colorectal cancer (CRC) is the third most common type of cancer and is responsible for 9 % of cancer deaths in both men and women in the USA for 2013. It is a heterogenous disease, and its three classification types are microsatellite instability, chromosomal instability, and CpG island methylator phenotype. Biomarkers are molecules, which can be used as indicators of cancer. They have the potential to achieve great sensitivities and specificities in diagnosis and prognosis of CRC. DNA methylation biomarkers are epigenetic markers, more specifically genes that become silenced after aberrant methylation of their promoter in CRC. Some methylation biomarkers like SEPT9 (ColoVantage®) and vimentin (ColoSureTM) are already commercially available. Other blood and fecal-based biomarkers are currently under investigation and clinical studies so that they can be used in the near future. Biomarker panels are also currently being studied since they show great potential in diagnosis as they can combine robust biomarkers to achieve even greater sensitivities than single markers. Finally, methylation-sensitive microRNAs (miRNAs) are very promising markers, and their investigation as biomarkers, is only at primitive stage.
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Keywords {🔍}

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Topics {✒️}

month download article/chapter cancro del colon-retto tnf-α-induced apoptosis hsa-mir-9 methylation status intronic microrna hsa-mir-342 large population-based sample sessile serrated adenoma/polyps tumour suppressor mir-149 pivotal tumour suppressor full article pdf dna methylation biomarkers tumor cell resistance privacy choices/manage cookies cpg island methylation molecular medicine aims combine robust biomarkers fecal-based biomarkers fecal dna testing related subjects sided colon cancers article gyparaki show great potential potential tumor suppressors dlc1 gene methylation dna repair genes reliable screening method colorectal hyperplastic polyps stool dna test runx3 promoter methylation colorectal cancer screening hypermethylated sfrp2 gene host gene evl european economic area reinacher-schick ac partouns-hendriks iejm braf v600e mutation detecting colorectal neoplasia specific blood test de bruïne ap de hoon jpj conditions privacy policy specific chromosomal alterations sporadic colorectal cancer colorectal cancer pathogenesis differentiated colorectal cancer advanced colorectal cancer serum tumor marker eurocare working group early 21st century kunz-schughart la

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      headline:DNA methylation biomarkers as diagnostic and prognostic tools in colorectal cancer
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