
DOI . ORG {
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Title[redir]:
Brain imaging of neurovascular dysfunction in Alzheimerās disease | Acta Neuropathologica
Description:
Neurovascular dysfunction, including bloodābrain barrier (BBB) breakdown and cerebral blood flow (CBF) dysregulation and reduction, are increasingly recognized to contribute to Alzheimerās disease (AD). The spatial and temporal relationships between different pathophysiological events during preclinical stages of AD, including cerebrovascular dysfunction and pathology, amyloid and tau pathology, and brain structural and functional changes remain, however, still unclear. Recent advances in neuroimaging techniques, i.e., magnetic resonance imaging (MRI) and positron emission tomography (PET), offer new possibilities to understand how the human brain works in health and disease. This includes methods to detect subtle regional changes in the cerebrovascular system integrity. Here, we focus on the neurovascular imaging techniques to evaluate regional BBB permeability (dynamic contrast-enhanced MRI), regional CBF changes (arterial spin labeling- and functional-MRI), vascular pathology (structural MRI), and cerebral metabolism (PET) in the living human brain, and examine how they can inform about neurovascular dysfunction and vascular pathophysiology in dementia and AD. Altogether, these neuroimaging approaches will continue to elucidate the spatio-temporal progression of vascular and neurodegenerative processes in dementia and AD and how they relate to each other.
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Keywords {š}
pubmed, scholar, google, article, alzheimers, cas, disease, central, imaging, brain, blood, flow, cerebral, mri, neurol, cognitive, impairment, functional, cereb, bloodbrain, barrier, mild, aging, neurosci, metab, zlokovic, neuroimaging, amyloid, magnetic, arterial, alzheimer, neurology, resonance, soc, memory, dois, int, sperling, neurovascular, dysfunction, fmri, hippocampal, study, usa, dynamic, vascular, ann, normal, med, dementia,
Topics {āļø}
month download article/chapter d-alanine2-d-leucine5-enkephalin depth-resolved optical imaging bloodābrain barrier permeability bloodābrain barrier breakdown blood-brain-barrier leakage amyloid β-peptide elimination including bloodābrain barrier n-terminal amino acid bloodābrain barrier dysfunction bloodābrain barrier integrity positron emission tomography voxel-based morphometry studies guzmĆ”n-de-villoria ja bloodābrain barrier link magnetic resonance imaging dynamic contrast-enhanced mri gadolinium-based contrast media av45-a07 study group predefined antero-temporal region av45-a05 study group imaging beta-amyloid pathology temporal beta-amyloid deposition full article pdf influence short-term decline hillman emc apoe ε4 interact year testāretest reliability case-control mri study [18f]fdg pet study age-related white matter multiple-time uptake data bloodābrain barrier arterial spin labeling arterial spin labeling arterial spin-labeling brain blood flow functional mr imaging cerebral blood flow cortical blood flow villemagne vl common blood flow dynamic contrast-enhanced including cerebrovascular dysfunction shulman gl de leeuw f impaired cerebral autoregulation magn reson med functional brain imaging privacy choices/manage cookies
Questions {ā}
- Iadecola C (1993) Regulation of the cerebral microcirculation during neural activity: is nitric oxide the missing link?
- Jagust W (2015) Is amyloid-β harmful to the brain?
- Turner R (2002) How much cortex can a vein drain?
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headline:Brain imaging of neurovascular dysfunction in Alzheimerās disease
description:Neurovascular dysfunction, including bloodābrain barrier (BBB) breakdown and cerebral blood flow (CBF) dysregulation and reduction, are increasingly recognized to contribute to Alzheimerās disease (AD). The spatial and temporal relationships between different pathophysiological events during preclinical stages of AD, including cerebrovascular dysfunction and pathology, amyloid and tau pathology, and brain structural and functional changes remain, however, still unclear. Recent advances in neuroimaging techniques, i.e., magnetic resonance imaging (MRI) and positron emission tomography (PET), offer new possibilities to understand how the human brain works in health and disease. This includes methods to detect subtle regional changes in the cerebrovascular system integrity. Here, we focus on the neurovascular imaging techniques to evaluate regional BBB permeability (dynamic contrast-enhanced MRI), regional CBF changes (arterial spin labeling- and functional-MRI), vascular pathology (structural MRI), and cerebral metabolism (PET) in the living human brain, and examine how they can inform about neurovascular dysfunction and vascular pathophysiology in dementia and AD. Altogether, these neuroimaging approaches will continue to elucidate the spatio-temporal progression of vascular and neurodegenerative processes in dementia and AD and how they relate to each other.
datePublished:2016-04-01T00:00:00Z
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Neurovascular dysfunction
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Magnetic resonance imaging
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headline:Brain imaging of neurovascular dysfunction in Alzheimerās disease
description:Neurovascular dysfunction, including bloodābrain barrier (BBB) breakdown and cerebral blood flow (CBF) dysregulation and reduction, are increasingly recognized to contribute to Alzheimerās disease (AD). The spatial and temporal relationships between different pathophysiological events during preclinical stages of AD, including cerebrovascular dysfunction and pathology, amyloid and tau pathology, and brain structural and functional changes remain, however, still unclear. Recent advances in neuroimaging techniques, i.e., magnetic resonance imaging (MRI) and positron emission tomography (PET), offer new possibilities to understand how the human brain works in health and disease. This includes methods to detect subtle regional changes in the cerebrovascular system integrity. Here, we focus on the neurovascular imaging techniques to evaluate regional BBB permeability (dynamic contrast-enhanced MRI), regional CBF changes (arterial spin labeling- and functional-MRI), vascular pathology (structural MRI), and cerebral metabolism (PET) in the living human brain, and examine how they can inform about neurovascular dysfunction and vascular pathophysiology in dementia and AD. Altogether, these neuroimaging approaches will continue to elucidate the spatio-temporal progression of vascular and neurodegenerative processes in dementia and AD and how they relate to each other.
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Analytics and Tracking {š}
- Google Tag Manager
Libraries {š}
- Clipboard.js
- Prism.js
Emails and Hosting {āļø}
Mail Servers:
- mx.zoho.eu
- mx2.zoho.eu
- mx3.zoho.eu
Name Servers:
- josh.ns.cloudflare.com
- zita.ns.cloudflare.com
CDN Services {š¦}
- Crossref