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Title:
A Primer on Functional Magnetic Resonance Imaging | Neuropsychology Review
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In this manuscript, basic principles of functional magnetic resonance imaging (fMRI) are reviewed. In the first section, two intrinsic mechanisms of magnetic resonance image contrast related to the longitudinal and transverse components of relaxing spins and their relaxation rates, T1 and T2, are described. In the second section, the biophysical mechanisms that alter the apparent transverse relaxation time, $$T_2^*$$ , in blood oxygenation level dependent (BOLD) studies and the creation of BOLD activation maps are discussed. The physiological complexity of the BOLD signal is emphasized. In the third section, arterial spin labeling (ASL) measures of cerebral blood flow are presented. Arterial spin labeling inverts or saturates the magnetization of flowing spins to measure the rate of delivery of blood to capillaries. In the fourth section, calibrated fMRI, which uses BOLD and ASL to infer alterations of oxygen utilization during behavioral activation, is reviewed. The discussion concludes with challenges confronting studies of individual cases.
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month download article/chapter echo-planar mr imaging diffusion-weighted studies magnetic resonance imaging cerebrovascular post-arteriole windkessel event-related fmri contrast nmr imaging process functional brain imaging magnetic resonance image nonlinear event-related responses pet/ct installations dynamic functional imaging quantitative perfusion imaging trial-based experimental design oxygen-sensitive contrast arterial spin labeling mr perfusion imaging functional brain mapping full article pdf privacy choices/manage cookies calibrated functional mri mr contrast due human brain mapping cerebral blood flow event-related fmri cerebral oxygen consumption high magnetic fields perfusion-based fmri altered arterial tensions cerebral blood volume magnetic resonance alternating radio frequency quantitative imaging functional activation measured clinical trial design perfusion imaging oxygen consumption response cbf/cmro2 coupling measured latest articles multiple trial types brain energy metabolism mr perfusion studies cerebral oxidative metabolism human brain function european economic area oxygen utilization check access constant interstimulus interval finger-thumb apposition absolute relaxation rates
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headline:A Primer on Functional Magnetic Resonance Imaging
description:In this manuscript, basic principles of functional magnetic resonance imaging (fMRI) are reviewed. In the first section, two intrinsic mechanisms of magnetic resonance image contrast related to the longitudinal and transverse components of relaxing spins and their relaxation rates, T1 and T2, are described. In the second section, the biophysical mechanisms that alter the apparent transverse relaxation time,
$$T_2^*$$
, in blood oxygenation level dependent (BOLD) studies and the creation of BOLD activation maps are discussed. The physiological complexity of the BOLD signal is emphasized. In the third section, arterial spin labeling (ASL) measures of cerebral blood flow are presented. Arterial spin labeling inverts or saturates the magnetization of flowing spins to measure the rate of delivery of blood to capillaries. In the fourth section, calibrated fMRI, which uses BOLD and ASL to infer alterations of oxygen utilization during behavioral activation, is reviewed. The discussion concludes with challenges confronting studies of individual cases.
datePublished:2007-04-28T00:00:00Z
dateModified:2007-04-28T00:00:00Z
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Functional magnetic resonance imaging
Perfusion magnetic resonance imaging
Regional blood flow
Cerebral oxygen metabolism
Neurosciences
Neuropsychology
Neurology
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headline:A Primer on Functional Magnetic Resonance Imaging
description:In this manuscript, basic principles of functional magnetic resonance imaging (fMRI) are reviewed. In the first section, two intrinsic mechanisms of magnetic resonance image contrast related to the longitudinal and transverse components of relaxing spins and their relaxation rates, T1 and T2, are described. In the second section, the biophysical mechanisms that alter the apparent transverse relaxation time,
$$T_2^*$$
, in blood oxygenation level dependent (BOLD) studies and the creation of BOLD activation maps are discussed. The physiological complexity of the BOLD signal is emphasized. In the third section, arterial spin labeling (ASL) measures of cerebral blood flow are presented. Arterial spin labeling inverts or saturates the magnetization of flowing spins to measure the rate of delivery of blood to capillaries. In the fourth section, calibrated fMRI, which uses BOLD and ASL to infer alterations of oxygen utilization during behavioral activation, is reviewed. The discussion concludes with challenges confronting studies of individual cases.
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Functional magnetic resonance imaging
Perfusion magnetic resonance imaging
Regional blood flow
Cerebral oxygen metabolism
Neurosciences
Neuropsychology
Neurology
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