DOI . ORG {}

Analyzed Page
Matching Content Categories
CMS
Monthly Traffic Estimate
How Does Doi.org Make Money
Keywords
Topics
Questions
Schema
External Links
Analytics And Tracking
Libraries
Hosting Providers
CDN Services

We began analyzing https://link.springer.com/article/10.1007/s00296-019-04417-2, but it redirected us to https://link.springer.com/article/10.1007/s00296-019-04417-2. The analysis below is for the second page.

Title[redir]:
Peripheral blood mononuclear cell proteome profile in Behçet’s syndrome | Rheumatology International
Description:
Behçet’s syndrome (BS) is a systemic inflammatory disorder with unknown etiology. Investigation of proteome profiles of disease specific cells facilitates our understanding of the processes and related molecular pathways, especially in disorders like BS with complex inheritance pattern and clinical heterogeneity. In the current study, we evaluated the peripheral blood mononuclear cells (PBMCs) proteome of 59 patients with BS (33 in active and 26 in inactive phases) and of 28 healthy controls using two-dimensional fluorescence difference gel electrophoresis (2D-DIGE). Differentially expressed protein spots with at least twofold and/or statistically significant change (p ≤ 0.05) between active BS vs inactive BS, and also active BS vs healthy controls were identified by mass spectrometry (MALDI-TOF/TOF). Bioinformatic analyses revealed 16 differentially expressed proteins (12 of them in active vs inactive BS comparison, whereas 11 of them for active BS vs healthy control comparison) belonging to glycolysis, cytoskeleton organization, protein folding, and regulation of blood coagulation pathways. Stathmin (active BS vs inactive BS; fourfold, active BS vs healthy control; 4.7-fold) and WD repeat-containing protein-1 (active BS vs inactive BS; 2.7-fold, active BS vs healthy control; 2.7-fold), which are cytoskeleton-related proteins, were found to be lower in active patients compared to inactive patients and healthy control. Decreased levels of calreticulin (active BS vs inactive BS; 1.29-fold) and heat shock 70 kDa protein 8 (active BS vs healthy control; 1.5-fold) which are involved in protein folding and endoplasmic reticulum (ER) stress process, were observed in patients with active phase of BS. Down-regulation of protein folding and ER stress process proteins in BS patients may further support the involvement of ER stress in BS.

Matching Content Categories {📚}

Health & Fitness
Science
Education

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Doi.org Make Money? {💸}

We're unsure how the site profits.

Websites don't always need to be profitable; some serve as platforms for education or personal expression. Websites can serve multiple purposes. And this might be one of them. Doi.org could have a money-making trick up its sleeve, but it's undetectable for now.

Keywords {🔍}

pubmed, article, google, scholar, cas, disease, behçets, central, protein, study, active, proteins, patients, istanbul, blood, research, proteome, immunol, analysis, cell, syndrome, inactive, healthy, access, rheumatol, arthritis, kim, stress, nat, res, exp, turkey, privacy, cookies, content, data, rheumatology, peripheral, mononuclear, manuscript, seyahi, control, fold, calreticulin, behcets, proteomic, proteomics, gül, yang, lee,

Topics {✒️}

axin/β-catenin signaling pathway �mhc-i-opathy’-unified concept month download article/chapter genome-wide association study anti-endothelial cell antibody anti-alpha-enolase antibody cofilin partner aip1/wdr1 actin-regulatory gene wdr1 eda tahir turanli 2d-dige maldi-tof/tof international study group dimensional gel electrophoresis i̇stanbul university—cerrahpaşa i̇stanbul technical university full article pdf er stress proteins cytoskeleton-related proteins blood coagulation pathways de almeida de blood proteins human alpha-enolase privacy choices/manage cookies systemic inflammatory disorder scientific research council scientific research fund related subjects selenium binding protein genetics research centre related molecular pathways tahir turanli lectin-complement pathway aydin sz immune-related biomarkers remmers ef article log european economic area complex inheritance pattern fructose-bisphosphate aldolase heterogeneous nuclear ribonucleoprotein il23r-il12rb2 regions proteome res 7 kile bt malignant solid tumors glucose metabolism enzyme modulates immune response anti-calreticulin antibodies providing financial grants aka performed experiments relevant biological materials

Questions {❓}

Xavier JM, Shahram F, Sousa I, Davatchi F, Matos M, Abdollahi BS, Sobral J, Nadji A, Oliveira M, Ghaderibarim F, Shafiee NM, Oliveira SA (2015) FUT2: filling the gap between genes and environment in Behcet’s disease?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Peripheral blood mononuclear cell proteome profile in Behçet’s syndrome
         description:Behçet’s syndrome (BS) is a systemic inflammatory disorder with unknown etiology. Investigation of proteome profiles of disease specific cells facilitates our understanding of the processes and related molecular pathways, especially in disorders like BS with complex inheritance pattern and clinical heterogeneity. In the current study, we evaluated the peripheral blood mononuclear cells (PBMCs) proteome of 59 patients with BS (33 in active and 26 in inactive phases) and of 28 healthy controls using two-dimensional fluorescence difference gel electrophoresis (2D-DIGE). Differentially expressed protein spots with at least twofold and/or statistically significant change (p ≤ 0.05) between active BS vs inactive BS, and also active BS vs healthy controls were identified by mass spectrometry (MALDI-TOF/TOF). Bioinformatic analyses revealed 16 differentially expressed proteins (12 of them in active vs inactive BS comparison, whereas 11 of them for active BS vs healthy control comparison) belonging to glycolysis, cytoskeleton organization, protein folding, and regulation of blood coagulation pathways. Stathmin (active BS vs inactive BS; fourfold, active BS vs healthy control; 4.7-fold) and WD repeat-containing protein-1 (active BS vs inactive BS; 2.7-fold, active BS vs healthy control; 2.7-fold), which are cytoskeleton-related proteins, were found to be lower in active patients compared to inactive patients and healthy control. Decreased levels of calreticulin (active BS vs inactive BS; 1.29-fold) and heat shock 70 kDa protein 8 (active BS vs healthy control; 1.5-fold) which are involved in protein folding and endoplasmic reticulum (ER) stress process, were observed in patients with active phase of BS. Down-regulation of protein folding and ER stress process proteins in BS patients may further support the involvement of ER stress in BS.
         datePublished:2019-08-14T00:00:00Z
         dateModified:2019-08-14T00:00:00Z
         pageStart:65
         pageEnd:74
         sameAs:https://doi.org/10.1007/s00296-019-04417-2
         keywords:
            Behçet’s syndrome
            Proteome
            2D-DIGE
            ER stress
            Rheumatology
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00296-019-04417-2/MediaObjects/296_2019_4417_Fig1_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00296-019-04417-2/MediaObjects/296_2019_4417_Fig2_HTML.png
         isPartOf:
            name:Rheumatology International
            issn:
               1437-160X
               0172-8172
            volumeNumber:40
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer Berlin Heidelberg
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Asli Kirectepe Aydin
               url:http://orcid.org/0000-0001-8289-5191
               affiliation:
                     name:Graduate School of Science, Engineering and Technology, İstanbul Technical University
                     address:
                        name:Department of Molecular Biology-Genetics and Biotechnology, Graduate School of Science, Engineering and Technology, İstanbul Technical University, İstanbul, Turkey
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Yeşim Özgüler
               url:http://orcid.org/0000-0002-2082-4715
               affiliation:
                     name:Cerrahpaşa Medical Faculty, İstanbul University—Cerrahpaşa
                     address:
                        name:Division of Rheumatology, Department of Internal Medicine, Cerrahpaşa Medical Faculty, İstanbul University—Cerrahpaşa, Istanbul, Turkey
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Didar Uçar
               url:http://orcid.org/0000-0002-3469-7307
               affiliation:
                     name:Cerrahpaşa Medical Faculty, İstanbul University—Cerrahpaşa
                     address:
                        name:Division of Ophthalmology, Department of Surgical Medicine, Cerrahpaşa Medical Faculty, İstanbul University—Cerrahpaşa, Istanbul, Turkey
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Murat Kasap
               url:http://orcid.org/0000-0001-8527-2096
               affiliation:
                     name:Kocaeli University
                     address:
                        name:Department of Medical Biology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Gürler Akpınar
               url:http://orcid.org/0000-0002-9675-3714
               affiliation:
                     name:Kocaeli University
                     address:
                        name:Department of Medical Biology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Emire Seyahi
               url:http://orcid.org/0000-0003-4965-2918
               affiliation:
                     name:Cerrahpaşa Medical Faculty, İstanbul University—Cerrahpaşa
                     address:
                        name:Division of Rheumatology, Department of Internal Medicine, Cerrahpaşa Medical Faculty, İstanbul University—Cerrahpaşa, Istanbul, Turkey
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Eda Tahir Turanli
               url:http://orcid.org/0000-0002-0789-0398
               affiliation:
                     name:Istanbul Technical University
                     address:
                        name:Department of Molecular Biology and Genetics, Dr. Orhan Öcalgiray, Molecular Biology-Biotechnology and Genetics Research Centre (MOBGAM), Graduate School of Science, Engineering and Technology, Istanbul Technical University, Istanbul, Turkey
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Peripheral blood mononuclear cell proteome profile in Behçet’s syndrome
      description:Behçet’s syndrome (BS) is a systemic inflammatory disorder with unknown etiology. Investigation of proteome profiles of disease specific cells facilitates our understanding of the processes and related molecular pathways, especially in disorders like BS with complex inheritance pattern and clinical heterogeneity. In the current study, we evaluated the peripheral blood mononuclear cells (PBMCs) proteome of 59 patients with BS (33 in active and 26 in inactive phases) and of 28 healthy controls using two-dimensional fluorescence difference gel electrophoresis (2D-DIGE). Differentially expressed protein spots with at least twofold and/or statistically significant change (p ≤ 0.05) between active BS vs inactive BS, and also active BS vs healthy controls were identified by mass spectrometry (MALDI-TOF/TOF). Bioinformatic analyses revealed 16 differentially expressed proteins (12 of them in active vs inactive BS comparison, whereas 11 of them for active BS vs healthy control comparison) belonging to glycolysis, cytoskeleton organization, protein folding, and regulation of blood coagulation pathways. Stathmin (active BS vs inactive BS; fourfold, active BS vs healthy control; 4.7-fold) and WD repeat-containing protein-1 (active BS vs inactive BS; 2.7-fold, active BS vs healthy control; 2.7-fold), which are cytoskeleton-related proteins, were found to be lower in active patients compared to inactive patients and healthy control. Decreased levels of calreticulin (active BS vs inactive BS; 1.29-fold) and heat shock 70 kDa protein 8 (active BS vs healthy control; 1.5-fold) which are involved in protein folding and endoplasmic reticulum (ER) stress process, were observed in patients with active phase of BS. Down-regulation of protein folding and ER stress process proteins in BS patients may further support the involvement of ER stress in BS.
      datePublished:2019-08-14T00:00:00Z
      dateModified:2019-08-14T00:00:00Z
      pageStart:65
      pageEnd:74
      sameAs:https://doi.org/10.1007/s00296-019-04417-2
      keywords:
         Behçet’s syndrome
         Proteome
         2D-DIGE
         ER stress
         Rheumatology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00296-019-04417-2/MediaObjects/296_2019_4417_Fig1_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00296-019-04417-2/MediaObjects/296_2019_4417_Fig2_HTML.png
      isPartOf:
         name:Rheumatology International
         issn:
            1437-160X
            0172-8172
         volumeNumber:40
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer Berlin Heidelberg
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Asli Kirectepe Aydin
            url:http://orcid.org/0000-0001-8289-5191
            affiliation:
                  name:Graduate School of Science, Engineering and Technology, İstanbul Technical University
                  address:
                     name:Department of Molecular Biology-Genetics and Biotechnology, Graduate School of Science, Engineering and Technology, İstanbul Technical University, İstanbul, Turkey
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yeşim Özgüler
            url:http://orcid.org/0000-0002-2082-4715
            affiliation:
                  name:Cerrahpaşa Medical Faculty, İstanbul University—Cerrahpaşa
                  address:
                     name:Division of Rheumatology, Department of Internal Medicine, Cerrahpaşa Medical Faculty, İstanbul University—Cerrahpaşa, Istanbul, Turkey
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Didar Uçar
            url:http://orcid.org/0000-0002-3469-7307
            affiliation:
                  name:Cerrahpaşa Medical Faculty, İstanbul University—Cerrahpaşa
                  address:
                     name:Division of Ophthalmology, Department of Surgical Medicine, Cerrahpaşa Medical Faculty, İstanbul University—Cerrahpaşa, Istanbul, Turkey
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Murat Kasap
            url:http://orcid.org/0000-0001-8527-2096
            affiliation:
                  name:Kocaeli University
                  address:
                     name:Department of Medical Biology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Gürler Akpınar
            url:http://orcid.org/0000-0002-9675-3714
            affiliation:
                  name:Kocaeli University
                  address:
                     name:Department of Medical Biology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Emire Seyahi
            url:http://orcid.org/0000-0003-4965-2918
            affiliation:
                  name:Cerrahpaşa Medical Faculty, İstanbul University—Cerrahpaşa
                  address:
                     name:Division of Rheumatology, Department of Internal Medicine, Cerrahpaşa Medical Faculty, İstanbul University—Cerrahpaşa, Istanbul, Turkey
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Eda Tahir Turanli
            url:http://orcid.org/0000-0002-0789-0398
            affiliation:
                  name:Istanbul Technical University
                  address:
                     name:Department of Molecular Biology and Genetics, Dr. Orhan Öcalgiray, Molecular Biology-Biotechnology and Genetics Research Centre (MOBGAM), Graduate School of Science, Engineering and Technology, Istanbul Technical University, Istanbul, Turkey
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Rheumatology International
      issn:
         1437-160X
         0172-8172
      volumeNumber:40
Organization:
      name:Springer Berlin Heidelberg
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Graduate School of Science, Engineering and Technology, İstanbul Technical University
      address:
         name:Department of Molecular Biology-Genetics and Biotechnology, Graduate School of Science, Engineering and Technology, İstanbul Technical University, İstanbul, Turkey
         type:PostalAddress
      name:Cerrahpaşa Medical Faculty, İstanbul University—Cerrahpaşa
      address:
         name:Division of Rheumatology, Department of Internal Medicine, Cerrahpaşa Medical Faculty, İstanbul University—Cerrahpaşa, Istanbul, Turkey
         type:PostalAddress
      name:Cerrahpaşa Medical Faculty, İstanbul University—Cerrahpaşa
      address:
         name:Division of Ophthalmology, Department of Surgical Medicine, Cerrahpaşa Medical Faculty, İstanbul University—Cerrahpaşa, Istanbul, Turkey
         type:PostalAddress
      name:Kocaeli University
      address:
         name:Department of Medical Biology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey
         type:PostalAddress
      name:Kocaeli University
      address:
         name:Department of Medical Biology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey
         type:PostalAddress
      name:Cerrahpaşa Medical Faculty, İstanbul University—Cerrahpaşa
      address:
         name:Division of Rheumatology, Department of Internal Medicine, Cerrahpaşa Medical Faculty, İstanbul University—Cerrahpaşa, Istanbul, Turkey
         type:PostalAddress
      name:Istanbul Technical University
      address:
         name:Department of Molecular Biology and Genetics, Dr. Orhan Öcalgiray, Molecular Biology-Biotechnology and Genetics Research Centre (MOBGAM), Graduate School of Science, Engineering and Technology, Istanbul Technical University, Istanbul, Turkey
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Asli Kirectepe Aydin
      url:http://orcid.org/0000-0001-8289-5191
      affiliation:
            name:Graduate School of Science, Engineering and Technology, İstanbul Technical University
            address:
               name:Department of Molecular Biology-Genetics and Biotechnology, Graduate School of Science, Engineering and Technology, İstanbul Technical University, İstanbul, Turkey
               type:PostalAddress
            type:Organization
      name:Yeşim Özgüler
      url:http://orcid.org/0000-0002-2082-4715
      affiliation:
            name:Cerrahpaşa Medical Faculty, İstanbul University—Cerrahpaşa
            address:
               name:Division of Rheumatology, Department of Internal Medicine, Cerrahpaşa Medical Faculty, İstanbul University—Cerrahpaşa, Istanbul, Turkey
               type:PostalAddress
            type:Organization
      name:Didar Uçar
      url:http://orcid.org/0000-0002-3469-7307
      affiliation:
            name:Cerrahpaşa Medical Faculty, İstanbul University—Cerrahpaşa
            address:
               name:Division of Ophthalmology, Department of Surgical Medicine, Cerrahpaşa Medical Faculty, İstanbul University—Cerrahpaşa, Istanbul, Turkey
               type:PostalAddress
            type:Organization
      name:Murat Kasap
      url:http://orcid.org/0000-0001-8527-2096
      affiliation:
            name:Kocaeli University
            address:
               name:Department of Medical Biology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey
               type:PostalAddress
            type:Organization
      name:Gürler Akpınar
      url:http://orcid.org/0000-0002-9675-3714
      affiliation:
            name:Kocaeli University
            address:
               name:Department of Medical Biology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey
               type:PostalAddress
            type:Organization
      name:Emire Seyahi
      url:http://orcid.org/0000-0003-4965-2918
      affiliation:
            name:Cerrahpaşa Medical Faculty, İstanbul University—Cerrahpaşa
            address:
               name:Division of Rheumatology, Department of Internal Medicine, Cerrahpaşa Medical Faculty, İstanbul University—Cerrahpaşa, Istanbul, Turkey
               type:PostalAddress
            type:Organization
      name:Eda Tahir Turanli
      url:http://orcid.org/0000-0002-0789-0398
      affiliation:
            name:Istanbul Technical University
            address:
               name:Department of Molecular Biology and Genetics, Dr. Orhan Öcalgiray, Molecular Biology-Biotechnology and Genetics Research Centre (MOBGAM), Graduate School of Science, Engineering and Technology, Istanbul Technical University, Istanbul, Turkey
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Molecular Biology-Genetics and Biotechnology, Graduate School of Science, Engineering and Technology, İstanbul Technical University, İstanbul, Turkey
      name:Division of Rheumatology, Department of Internal Medicine, Cerrahpaşa Medical Faculty, İstanbul University—Cerrahpaşa, Istanbul, Turkey
      name:Division of Ophthalmology, Department of Surgical Medicine, Cerrahpaşa Medical Faculty, İstanbul University—Cerrahpaşa, Istanbul, Turkey
      name:Department of Medical Biology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey
      name:Department of Medical Biology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey
      name:Division of Rheumatology, Department of Internal Medicine, Cerrahpaşa Medical Faculty, İstanbul University—Cerrahpaşa, Istanbul, Turkey
      name:Department of Molecular Biology and Genetics, Dr. Orhan Öcalgiray, Molecular Biology-Biotechnology and Genetics Research Centre (MOBGAM), Graduate School of Science, Engineering and Technology, Istanbul Technical University, Istanbul, Turkey
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(234)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

Emails and Hosting {✉️}

Mail Servers:

mx.zoho.eu
mx2.zoho.eu
mx3.zoho.eu

Name Servers:

josh.ns.cloudflare.com
zita.ns.cloudflare.com

CDN Services {📦}

Crossref

4.05s.