Here's how LINK.SPRINGER.COM makes money* and how much!

*Please read our disclaimer before using our estimates.
Loading...

LINK . SPRINGER . COM {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Link.springer.com Make Money
  6. Keywords
  7. Topics
  8. Schema
  9. External Links
  10. Analytics And Tracking
  11. Libraries
  12. CDN Services

We are analyzing https://link.springer.com/article/10.1186/ar2695.

Title:
Identification of novel genetic susceptibility loci for Behçet's disease using a genome-wide association study | Arthritis Research & Therapy
Description:
Introduction Behçet
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

  • Science
  • Education
  • Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We're unsure how the site profits.

Not all websites focus on profit; some are designed to educate, connect people, or share useful tools. People create websites for numerous reasons. And this could be one such example. Link.springer.com might be making money, but it's not detectable how they're doing it.

Keywords {🔍}

disease, behçets, patients, genetic, association, article, controls, dna, study, pubmed, identified, genotyping, table, gene, allele, oklahoma, google, scholar, research, loci, polymorphisms, behcets, cas, analysis, data, susceptibility, pooling, genes, genomewide, cohort, performed, candidate, snps, kiaa, usa, ubashb, risk, university, city, frequency, cpvl, loc, hlab, snp, arthritis, access, associations, ubac, linkage, medical,

Topics {✒️}

genome-wide association study genotyping success rate genetic linkage study t-cell receptor stimulation individual case-control genotyping genotyping single-nucleotide polymorphisms genetic linkage effect affymetrix 500k arrays grant number p20-rr015577 article download pdf pearson chi-square values genetic susceptibility loci protein tyrosine phosphatase single-nucleotide polymorphisms identified international study group dna pooling studies taqman genotyping technology candidate genetic loci tumor necrosis factor receptor tyrosine kinases research ethics committees full access privacy choices/manage cookies single-nucleotide polymorphisms article number r66 revealed genetic associations genechip genotyping 4 related subjects biomed central confer increased susceptibility remains incompletely understood sequencing-based typing single amino acid identified genetic associations article fei genetic association genetic loci european economic area oro-genital ulcers specific immunosuppressive medications institutional review boards initial discovery phase high molecular weight thermo fisher scientific hardy-weinberg equilibrium diverse biological functions experimental autoimmune encephalomyelitis pcr-sbt method normal macrophage function observed genotype frequency

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Identification of novel genetic susceptibility loci for Behçet's disease using a genome-wide association study
         description:Behçet's disease is a chronic systemic inflammatory disease that remains incompletely understood. Herein, we perform the first genome-wide association study in Behçet's disease. Using DNA pooling technology and the Affymetrix 500K arrays, we identified possible candidate gene associations with Behçet's disease in a cohort of 152 Behçet's disease patients and 172 healthy ethnically matched controls. Genetic loci that were identified in the pooling study were genotyped in patients and controls using TaqMan genotyping technology. We identified genetic associations between Behçet's disease and single-nucleotide polymorphisms (SNPs) in KIAA1529, CPVL, LOC100129342, UBASH3B, and UBAC2 (odds ratio = 2.04, 2.26, 1.84, 1.71, and 1.61, respectively; P value = 4.2 × 10-5, 1.0 × 10-4, 3.0 × 10-4, 1.5 × 10-3, and 5.8 × 10-3, respectively). Among the associated SNPs, the Behçet's disease-risk allele in rs2061634 leads to substitution of serine to cysteine at amino acid position 995 (S995C) in the KIAA1529 protein. Using an unbiased whole-genome genetic association approach, we identified novel candidate genetic loci that are associated with increased susceptibility for Behçet's disease. These findings will help to better understand the pathogenesis of Behçet's disease and identify novel targets for therapeutic intervention.
         datePublished:2009-05-14T00:00:00Z
         dateModified:2009-05-14T00:00:00Z
         pageStart:1
         pageEnd:7
         license:http://creativecommons.org/licenses/by/2.0/
         sameAs:https://doi.org/10.1186/ar2695
         keywords:
            500K Array
            Genetic Linkage Study
            Central Nervous System Vasculitis
            Genotyping Success Rate
            Genetic Susceptibility Locus
            Rheumatology
            Orthopedics
         image:
         isPartOf:
            name:Arthritis Research & Therapy
            issn:
               1478-6354
            volumeNumber:11
            type:
               Periodical
               PublicationVolume
         publisher:
            name:BioMed Central
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Yiping Fei
               affiliation:
                     name:University of Oklahoma Health Sciences Center
                     address:
                        name:Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, USA
                        type:PostalAddress
                     type:Organization
                     name:Oklahoma Medical Research Foundation
                     address:
                        name:Arthritis & Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Ryan Webb
               affiliation:
                     name:Oklahoma Medical Research Foundation
                     address:
                        name:Arthritis & Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, USA
                        type:PostalAddress
                     type:Organization
                     name:University of Oklahoma Health Sciences Center
                     address:
                        name:College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Beth L Cobb
               affiliation:
                     name:Oklahoma Medical Research Foundation
                     address:
                        name:Arthritis & Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, USA
                        type:PostalAddress
                     type:Organization
                     name:JK Autoimmunity Inc.
                     address:
                        name:JK Autoimmunity Inc., Oklahoma City, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Haner Direskeneli
               affiliation:
                     name:Marmara University Medical School
                     address:
                        name:Division of Rheumatology, Department of Internal Medicine, Marmara University Medical School, Uskudar, Istanbul, Turkey
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Güher Saruhan-Direskeneli
               affiliation:
                     name:Istanbul University, Capa
                     address:
                        name:Department of Physiology, Istanbul Faculty of Medicine, Istanbul University, Capa, Istanbul, Turkey
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Amr H Sawalha
               affiliation:
                     name:University of Oklahoma Health Sciences Center
                     address:
                        name:Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, USA
                        type:PostalAddress
                     type:Organization
                     name:Oklahoma Medical Research Foundation
                     address:
                        name:Arthritis & Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, USA
                        type:PostalAddress
                     type:Organization
                     name:US Department of Veterans Affairs Medical Center
                     address:
                        name:US Department of Veterans Affairs Medical Center, Oklahoma City, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Identification of novel genetic susceptibility loci for Behçet's disease using a genome-wide association study
      description:Behçet's disease is a chronic systemic inflammatory disease that remains incompletely understood. Herein, we perform the first genome-wide association study in Behçet's disease. Using DNA pooling technology and the Affymetrix 500K arrays, we identified possible candidate gene associations with Behçet's disease in a cohort of 152 Behçet's disease patients and 172 healthy ethnically matched controls. Genetic loci that were identified in the pooling study were genotyped in patients and controls using TaqMan genotyping technology. We identified genetic associations between Behçet's disease and single-nucleotide polymorphisms (SNPs) in KIAA1529, CPVL, LOC100129342, UBASH3B, and UBAC2 (odds ratio = 2.04, 2.26, 1.84, 1.71, and 1.61, respectively; P value = 4.2 × 10-5, 1.0 × 10-4, 3.0 × 10-4, 1.5 × 10-3, and 5.8 × 10-3, respectively). Among the associated SNPs, the Behçet's disease-risk allele in rs2061634 leads to substitution of serine to cysteine at amino acid position 995 (S995C) in the KIAA1529 protein. Using an unbiased whole-genome genetic association approach, we identified novel candidate genetic loci that are associated with increased susceptibility for Behçet's disease. These findings will help to better understand the pathogenesis of Behçet's disease and identify novel targets for therapeutic intervention.
      datePublished:2009-05-14T00:00:00Z
      dateModified:2009-05-14T00:00:00Z
      pageStart:1
      pageEnd:7
      license:http://creativecommons.org/licenses/by/2.0/
      sameAs:https://doi.org/10.1186/ar2695
      keywords:
         500K Array
         Genetic Linkage Study
         Central Nervous System Vasculitis
         Genotyping Success Rate
         Genetic Susceptibility Locus
         Rheumatology
         Orthopedics
      image:
      isPartOf:
         name:Arthritis Research & Therapy
         issn:
            1478-6354
         volumeNumber:11
         type:
            Periodical
            PublicationVolume
      publisher:
         name:BioMed Central
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Yiping Fei
            affiliation:
                  name:University of Oklahoma Health Sciences Center
                  address:
                     name:Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, USA
                     type:PostalAddress
                  type:Organization
                  name:Oklahoma Medical Research Foundation
                  address:
                     name:Arthritis & Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ryan Webb
            affiliation:
                  name:Oklahoma Medical Research Foundation
                  address:
                     name:Arthritis & Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, USA
                     type:PostalAddress
                  type:Organization
                  name:University of Oklahoma Health Sciences Center
                  address:
                     name:College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Beth L Cobb
            affiliation:
                  name:Oklahoma Medical Research Foundation
                  address:
                     name:Arthritis & Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, USA
                     type:PostalAddress
                  type:Organization
                  name:JK Autoimmunity Inc.
                  address:
                     name:JK Autoimmunity Inc., Oklahoma City, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Haner Direskeneli
            affiliation:
                  name:Marmara University Medical School
                  address:
                     name:Division of Rheumatology, Department of Internal Medicine, Marmara University Medical School, Uskudar, Istanbul, Turkey
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Güher Saruhan-Direskeneli
            affiliation:
                  name:Istanbul University, Capa
                  address:
                     name:Department of Physiology, Istanbul Faculty of Medicine, Istanbul University, Capa, Istanbul, Turkey
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Amr H Sawalha
            affiliation:
                  name:University of Oklahoma Health Sciences Center
                  address:
                     name:Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, USA
                     type:PostalAddress
                  type:Organization
                  name:Oklahoma Medical Research Foundation
                  address:
                     name:Arthritis & Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, USA
                     type:PostalAddress
                  type:Organization
                  name:US Department of Veterans Affairs Medical Center
                  address:
                     name:US Department of Veterans Affairs Medical Center, Oklahoma City, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Arthritis Research & Therapy
      issn:
         1478-6354
      volumeNumber:11
Organization:
      name:BioMed Central
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:University of Oklahoma Health Sciences Center
      address:
         name:Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, USA
         type:PostalAddress
      name:Oklahoma Medical Research Foundation
      address:
         name:Arthritis & Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, USA
         type:PostalAddress
      name:Oklahoma Medical Research Foundation
      address:
         name:Arthritis & Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, USA
         type:PostalAddress
      name:University of Oklahoma Health Sciences Center
      address:
         name:College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, USA
         type:PostalAddress
      name:Oklahoma Medical Research Foundation
      address:
         name:Arthritis & Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, USA
         type:PostalAddress
      name:JK Autoimmunity Inc.
      address:
         name:JK Autoimmunity Inc., Oklahoma City, USA
         type:PostalAddress
      name:Marmara University Medical School
      address:
         name:Division of Rheumatology, Department of Internal Medicine, Marmara University Medical School, Uskudar, Istanbul, Turkey
         type:PostalAddress
      name:Istanbul University, Capa
      address:
         name:Department of Physiology, Istanbul Faculty of Medicine, Istanbul University, Capa, Istanbul, Turkey
         type:PostalAddress
      name:University of Oklahoma Health Sciences Center
      address:
         name:Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, USA
         type:PostalAddress
      name:Oklahoma Medical Research Foundation
      address:
         name:Arthritis & Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, USA
         type:PostalAddress
      name:US Department of Veterans Affairs Medical Center
      address:
         name:US Department of Veterans Affairs Medical Center, Oklahoma City, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Yiping Fei
      affiliation:
            name:University of Oklahoma Health Sciences Center
            address:
               name:Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, USA
               type:PostalAddress
            type:Organization
            name:Oklahoma Medical Research Foundation
            address:
               name:Arthritis & Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, USA
               type:PostalAddress
            type:Organization
      name:Ryan Webb
      affiliation:
            name:Oklahoma Medical Research Foundation
            address:
               name:Arthritis & Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, USA
               type:PostalAddress
            type:Organization
            name:University of Oklahoma Health Sciences Center
            address:
               name:College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, USA
               type:PostalAddress
            type:Organization
      name:Beth L Cobb
      affiliation:
            name:Oklahoma Medical Research Foundation
            address:
               name:Arthritis & Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, USA
               type:PostalAddress
            type:Organization
            name:JK Autoimmunity Inc.
            address:
               name:JK Autoimmunity Inc., Oklahoma City, USA
               type:PostalAddress
            type:Organization
      name:Haner Direskeneli
      affiliation:
            name:Marmara University Medical School
            address:
               name:Division of Rheumatology, Department of Internal Medicine, Marmara University Medical School, Uskudar, Istanbul, Turkey
               type:PostalAddress
            type:Organization
      name:Güher Saruhan-Direskeneli
      affiliation:
            name:Istanbul University, Capa
            address:
               name:Department of Physiology, Istanbul Faculty of Medicine, Istanbul University, Capa, Istanbul, Turkey
               type:PostalAddress
            type:Organization
      name:Amr H Sawalha
      affiliation:
            name:University of Oklahoma Health Sciences Center
            address:
               name:Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, USA
               type:PostalAddress
            type:Organization
            name:Oklahoma Medical Research Foundation
            address:
               name:Arthritis & Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, USA
               type:PostalAddress
            type:Organization
            name:US Department of Veterans Affairs Medical Center
            address:
               name:US Department of Veterans Affairs Medical Center, Oklahoma City, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, USA
      name:Arthritis & Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, USA
      name:Arthritis & Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, USA
      name:College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, USA
      name:Arthritis & Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, USA
      name:JK Autoimmunity Inc., Oklahoma City, USA
      name:Division of Rheumatology, Department of Internal Medicine, Marmara University Medical School, Uskudar, Istanbul, Turkey
      name:Department of Physiology, Istanbul Faculty of Medicine, Istanbul University, Capa, Istanbul, Turkey
      name:Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, USA
      name:Arthritis & Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, USA
      name:US Department of Veterans Affairs Medical Center, Oklahoma City, USA

External Links {🔗}(81)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Clipboard.js
  • Foundation
  • Prism.js

CDN Services {📦}

  • Crossref

4.72s.