We are analyzing https://link.springer.com/article/10.1007/s10875-013-9885-2.

Title:
Serum Levels of Calreticulin in Correlation with Disease Activity in Patients with Rheumatoid Arthritis | Journal of Clinical Immunology
Description:
The aim of our study was to investigate the contribution of serum calreticulin (CRT) in the assessment of disease activity in rheumatoid arthritis (RA). Serum CRT levels were measured by ELISA in 70 patients with established RA, 30 systemic lupus erythematosus (SLE), 25 other autoimmune diseases, 20 osteoarthritis (OA), and 35 of healthy controls (HC). Correlations of CRT serum levels with disease activity [Disease Activity Score for 28 joints (DAS28)], erythrocyte sedimentation rate(ESR) and C-reactive protein (CRP) were assessed. Serum CRT levels were also detected in RA patients whose RF, anti-CCP and anti- MCV antibodies were positive and negative. Serum CRT levels in RA patients (4.817 ± 2.425 ng/ml) was significantly higher (P <0.05) compared with those in the serum of OA (3.574 ± 0.942 ng/ml), SLE (4.013 ± 1.536 ng/ml), other autoimmune diseases (3.882 ± 0.837 ng/ml) and HC (3.726 ± 0.627 ng/ml). Significant positive correlation of CRT with DAS28, ESR and CRP was found in RA patients. Furthermore, RA patients whose anti-CCP and anti-MCV antibodies were positive had higher levels of CRT (P < 0.01). Serum CRT levels were increased in patients with RA compared with those controls. Moreover, a significant correlation was observed between serum CRT levels and disease activity in RA. It might be used as a potential biomarker for clinical diagnosis and provide additional information regarding disease activity along with the traditional indices such as ESR and CRP.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Health & Fitness
Science
Education

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 7,625,932 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We're unsure how the site profits.

Not all websites focus on profit; some are designed to educate, connect people, or share useful tools. People create websites for numerous reasons. And this could be one such example. Link.springer.com could have a money-making trick up its sleeve, but it's undetectable for now.

Keywords {🔍}

arthritis, article, rheumatoid, pubmed, google, scholar, disease, activity, serum, cas, patients, calreticulin, levels, crt, rheumatol, wei, correlation, study, tianjin, privacy, cookies, content, information, journal, research, score, ngml, access, rheum, publish, search, clinical, min, fang, zheng, treatment, van, clin, immunol, data, log, immunology, march, wang, zhang, assessment, autoimmune, diseases, erythrocyte, sedimentation,

Topics {✒️}

month download article/chapter c-reactive protein eular response criteria full article pdf disease activity score privacy choices/manage cookies specialized research fund clinical immunology aims reactive oxygen metabolites anti- mcv antibodies anti-mcv antibodies citrullinated glycolytic enzymes fang zheng disease activity index disease activity marker predict disease activity de almeida de early rheumatoid arthritis arthritis res ther article ni synovial fluid levels serum rage levels european economic area erythrocyte sedimentation rate manag care pharm large observational cohort candidate autoantigens identified provide additional information serum adenosine deaminase crt serum levels serum crt levels van riel pl conditions privacy policy unexpected low level related subjects serum calprotectin level trends cell biol rheumatoid arthritis patients van leeuwen ma cell surface calreticulin article journal accepting optional cookies autoimmune diseases tianjin medical university journal finder publish ann rheum dis article log check access instant access prospective longitudinal study

Questions {❓}

Rheumatoid arthritis in 2003: where are we now with treatment?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Serum Levels of Calreticulin in Correlation with Disease Activity in Patients with Rheumatoid Arthritis
         description:The aim of our study was to investigate the contribution of serum calreticulin (CRT) in the assessment of disease activity in rheumatoid arthritis (RA). Serum CRT levels were measured by ELISA in 70 patients with established RA, 30 systemic lupus erythematosus (SLE), 25 other autoimmune diseases, 20 osteoarthritis (OA), and 35 of healthy controls (HC). Correlations of CRT serum levels with disease activity [Disease Activity Score for 28 joints (DAS28)], erythrocyte sedimentation rate(ESR) and C-reactive protein (CRP) were assessed. Serum CRT levels were also detected in RA patients whose RF, anti-CCP and anti- MCV antibodies were positive and negative. Serum CRT levels in RA patients (4.817 ± 2.425 ng/ml) was significantly higher (P <0.05) compared with those in the serum of OA (3.574 ± 0.942 ng/ml), SLE (4.013 ± 1.536 ng/ml), other autoimmune diseases (3.882 ± 0.837 ng/ml) and HC (3.726 ± 0.627 ng/ml). Significant positive correlation of CRT with DAS28, ESR and CRP was found in RA patients. Furthermore, RA patients whose anti-CCP and anti-MCV antibodies were positive had higher levels of CRT (P < 0.01). Serum CRT levels were increased in patients with RA compared with those controls. Moreover, a significant correlation was observed between serum CRT levels and disease activity in RA. It might be used as a potential biomarker for clinical diagnosis and provide additional information regarding disease activity along with the traditional indices such as ESR and CRP.
         datePublished:2013-03-27T00:00:00Z
         dateModified:2013-03-27T00:00:00Z
         pageStart:947
         pageEnd:953
         sameAs:https://doi.org/10.1007/s10875-013-9885-2
         keywords:
            Calreticulin
            rheumatoid arthritis
            disease activity
            DAS-28 score
            Immunology
            Infectious Diseases
            Internal Medicine
            Medical Microbiology
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10875-013-9885-2/MediaObjects/10875_2013_9885_Fig1_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10875-013-9885-2/MediaObjects/10875_2013_9885_Fig2_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10875-013-9885-2/MediaObjects/10875_2013_9885_Fig3_HTML.gif
         isPartOf:
            name:Journal of Clinical Immunology
            issn:
               1573-2592
               0271-9142
            volumeNumber:33
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer US
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Min Ni
               affiliation:
                     name:Tianjin Medical University
                     address:
                        name:School of Laboratory Medicine, Tianjin Medical University, Tianjin, China
                        type:PostalAddress
                     type:Organization
                     name:Tianjin Medical University
                     address:
                        name:Department of Immunology, Tianjin Medical University, Tianjin, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Wei Wei
               affiliation:
                     name:General Hospital, Tianjin Medical University
                     address:
                        name:Department of Rheumatology, General Hospital, Tianjin Medical University, Tianjin, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Yichao Wang
               affiliation:
                     name:Tianjin Medical University
                     address:
                        name:School of Laboratory Medicine, Tianjin Medical University, Tianjin, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Na Zhang
               affiliation:
                     name:General Hospital, Tianjin Medical University
                     address:
                        name:Department of Rheumatology, General Hospital, Tianjin Medical University, Tianjin, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Hongmei Ding
               affiliation:
                     name:Tianjin Medical University
                     address:
                        name:School of Laboratory Medicine, Tianjin Medical University, Tianjin, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Chen Shen
               affiliation:
                     name:Tianjin Medical University
                     address:
                        name:School of Laboratory Medicine, Tianjin Medical University, Tianjin, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Fang Zheng
               affiliation:
                     name:Tianjin Medical University
                     address:
                        name:School of Laboratory Medicine, Tianjin Medical University, Tianjin, China
                        type:PostalAddress
                     type:Organization
                     name:Tianjin Medical University
                     address:
                        name:Department of Immunology, Tianjin Medical University, Tianjin, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Serum Levels of Calreticulin in Correlation with Disease Activity in Patients with Rheumatoid Arthritis
      description:The aim of our study was to investigate the contribution of serum calreticulin (CRT) in the assessment of disease activity in rheumatoid arthritis (RA). Serum CRT levels were measured by ELISA in 70 patients with established RA, 30 systemic lupus erythematosus (SLE), 25 other autoimmune diseases, 20 osteoarthritis (OA), and 35 of healthy controls (HC). Correlations of CRT serum levels with disease activity [Disease Activity Score for 28 joints (DAS28)], erythrocyte sedimentation rate(ESR) and C-reactive protein (CRP) were assessed. Serum CRT levels were also detected in RA patients whose RF, anti-CCP and anti- MCV antibodies were positive and negative. Serum CRT levels in RA patients (4.817 ± 2.425 ng/ml) was significantly higher (P <0.05) compared with those in the serum of OA (3.574 ± 0.942 ng/ml), SLE (4.013 ± 1.536 ng/ml), other autoimmune diseases (3.882 ± 0.837 ng/ml) and HC (3.726 ± 0.627 ng/ml). Significant positive correlation of CRT with DAS28, ESR and CRP was found in RA patients. Furthermore, RA patients whose anti-CCP and anti-MCV antibodies were positive had higher levels of CRT (P < 0.01). Serum CRT levels were increased in patients with RA compared with those controls. Moreover, a significant correlation was observed between serum CRT levels and disease activity in RA. It might be used as a potential biomarker for clinical diagnosis and provide additional information regarding disease activity along with the traditional indices such as ESR and CRP.
      datePublished:2013-03-27T00:00:00Z
      dateModified:2013-03-27T00:00:00Z
      pageStart:947
      pageEnd:953
      sameAs:https://doi.org/10.1007/s10875-013-9885-2
      keywords:
         Calreticulin
         rheumatoid arthritis
         disease activity
         DAS-28 score
         Immunology
         Infectious Diseases
         Internal Medicine
         Medical Microbiology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10875-013-9885-2/MediaObjects/10875_2013_9885_Fig1_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10875-013-9885-2/MediaObjects/10875_2013_9885_Fig2_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10875-013-9885-2/MediaObjects/10875_2013_9885_Fig3_HTML.gif
      isPartOf:
         name:Journal of Clinical Immunology
         issn:
            1573-2592
            0271-9142
         volumeNumber:33
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer US
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Min Ni
            affiliation:
                  name:Tianjin Medical University
                  address:
                     name:School of Laboratory Medicine, Tianjin Medical University, Tianjin, China
                     type:PostalAddress
                  type:Organization
                  name:Tianjin Medical University
                  address:
                     name:Department of Immunology, Tianjin Medical University, Tianjin, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Wei Wei
            affiliation:
                  name:General Hospital, Tianjin Medical University
                  address:
                     name:Department of Rheumatology, General Hospital, Tianjin Medical University, Tianjin, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yichao Wang
            affiliation:
                  name:Tianjin Medical University
                  address:
                     name:School of Laboratory Medicine, Tianjin Medical University, Tianjin, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Na Zhang
            affiliation:
                  name:General Hospital, Tianjin Medical University
                  address:
                     name:Department of Rheumatology, General Hospital, Tianjin Medical University, Tianjin, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Hongmei Ding
            affiliation:
                  name:Tianjin Medical University
                  address:
                     name:School of Laboratory Medicine, Tianjin Medical University, Tianjin, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Chen Shen
            affiliation:
                  name:Tianjin Medical University
                  address:
                     name:School of Laboratory Medicine, Tianjin Medical University, Tianjin, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Fang Zheng
            affiliation:
                  name:Tianjin Medical University
                  address:
                     name:School of Laboratory Medicine, Tianjin Medical University, Tianjin, China
                     type:PostalAddress
                  type:Organization
                  name:Tianjin Medical University
                  address:
                     name:Department of Immunology, Tianjin Medical University, Tianjin, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Journal of Clinical Immunology
      issn:
         1573-2592
         0271-9142
      volumeNumber:33
Organization:
      name:Springer US
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Tianjin Medical University
      address:
         name:School of Laboratory Medicine, Tianjin Medical University, Tianjin, China
         type:PostalAddress
      name:Tianjin Medical University
      address:
         name:Department of Immunology, Tianjin Medical University, Tianjin, China
         type:PostalAddress
      name:General Hospital, Tianjin Medical University
      address:
         name:Department of Rheumatology, General Hospital, Tianjin Medical University, Tianjin, China
         type:PostalAddress
      name:Tianjin Medical University
      address:
         name:School of Laboratory Medicine, Tianjin Medical University, Tianjin, China
         type:PostalAddress
      name:General Hospital, Tianjin Medical University
      address:
         name:Department of Rheumatology, General Hospital, Tianjin Medical University, Tianjin, China
         type:PostalAddress
      name:Tianjin Medical University
      address:
         name:School of Laboratory Medicine, Tianjin Medical University, Tianjin, China
         type:PostalAddress
      name:Tianjin Medical University
      address:
         name:School of Laboratory Medicine, Tianjin Medical University, Tianjin, China
         type:PostalAddress
      name:Tianjin Medical University
      address:
         name:School of Laboratory Medicine, Tianjin Medical University, Tianjin, China
         type:PostalAddress
      name:Tianjin Medical University
      address:
         name:Department of Immunology, Tianjin Medical University, Tianjin, China
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Min Ni
      affiliation:
            name:Tianjin Medical University
            address:
               name:School of Laboratory Medicine, Tianjin Medical University, Tianjin, China
               type:PostalAddress
            type:Organization
            name:Tianjin Medical University
            address:
               name:Department of Immunology, Tianjin Medical University, Tianjin, China
               type:PostalAddress
            type:Organization
      name:Wei Wei
      affiliation:
            name:General Hospital, Tianjin Medical University
            address:
               name:Department of Rheumatology, General Hospital, Tianjin Medical University, Tianjin, China
               type:PostalAddress
            type:Organization
      name:Yichao Wang
      affiliation:
            name:Tianjin Medical University
            address:
               name:School of Laboratory Medicine, Tianjin Medical University, Tianjin, China
               type:PostalAddress
            type:Organization
      name:Na Zhang
      affiliation:
            name:General Hospital, Tianjin Medical University
            address:
               name:Department of Rheumatology, General Hospital, Tianjin Medical University, Tianjin, China
               type:PostalAddress
            type:Organization
      name:Hongmei Ding
      affiliation:
            name:Tianjin Medical University
            address:
               name:School of Laboratory Medicine, Tianjin Medical University, Tianjin, China
               type:PostalAddress
            type:Organization
      name:Chen Shen
      affiliation:
            name:Tianjin Medical University
            address:
               name:School of Laboratory Medicine, Tianjin Medical University, Tianjin, China
               type:PostalAddress
            type:Organization
      name:Fang Zheng
      affiliation:
            name:Tianjin Medical University
            address:
               name:School of Laboratory Medicine, Tianjin Medical University, Tianjin, China
               type:PostalAddress
            type:Organization
            name:Tianjin Medical University
            address:
               name:Department of Immunology, Tianjin Medical University, Tianjin, China
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:School of Laboratory Medicine, Tianjin Medical University, Tianjin, China
      name:Department of Immunology, Tianjin Medical University, Tianjin, China
      name:Department of Rheumatology, General Hospital, Tianjin Medical University, Tianjin, China
      name:School of Laboratory Medicine, Tianjin Medical University, Tianjin, China
      name:Department of Rheumatology, General Hospital, Tianjin Medical University, Tianjin, China
      name:School of Laboratory Medicine, Tianjin Medical University, Tianjin, China
      name:School of Laboratory Medicine, Tianjin Medical University, Tianjin, China
      name:School of Laboratory Medicine, Tianjin Medical University, Tianjin, China
      name:Department of Immunology, Tianjin Medical University, Tianjin, China
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(98)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

3.63s.

LINK . SPRINGER . COM {}