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DOI . ORG {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Keywords
  7. Topics
  8. Questions
  9. Schema
  10. External Links
  11. Analytics And Tracking
  12. Libraries
  13. Hosting Providers
  14. CDN Services

We began analyzing https://link.springer.com/article/10.1007/s00253-016-7885-x, but it redirected us to https://link.springer.com/article/10.1007/s00253-016-7885-x. The analysis below is for the second page.

Title[redir]:
Design and validation of an orally administrated active L. fermentum-L. acidophilus probiotic formulation using colorectal cancer Apc Min/+ mouse model | Applied Microbiology and Biotechnology
Description:
Probiotics have been shown to have beneficial properties in attenuating the risk of colorectal cancer (CRC) development. However, functional evidence to support such effects for some probiotic bacteria are relatively unknown. Here, we document a significant antioxidant, anti-proliferative and pro-apoptotic activities of Lactobacillus acidophilus ATCC 314 and Lactobacillus fermentum NCIMB 5221 on CRC cells, particularly when used in combination (La-Lf). Furthermore, a superior synergistic activity on the inhibition of tumor growth and modulation of cell proliferation and epithelial markers in the Apc Min/+ CRC mouse model was explored, based on the expression levels of Ki-67, E-cadherin, β-catenin, and cleaved caspase-3 (CC3) proteins. The anti-cancer activity of La-Lf co-culture was significantly enhanced in vitro with significant reduced proliferation (38.8 ± 6.9 %, P = 0.009) and increased apoptosis (413 RUL, P < 0.001) towards cancer cells, as well as significant protection of normal colon cell growth from toxic treatment (18.6 ± 9.8 %, P = 0.001). La-Lf formulation (1010cfu/animal/day) altered aspects of intestinal tumorigenesis by significantly reducing intestinal tumor multiplicity (1.7-fold, P = 0.016) and downregulating cellular proliferation markers, including β-catenin (P = 0.041) and Ki-67 (P = 0.008). In conclusion, La-Lf showed greater protection against intestinal tumorigenesis supporting a potential use as a biotherapeutic for the prevention of CRC.

Matching Content Categories {📚}

  • Education
  • Science
  • Health & Fitness

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🏙️ Massive Traffic: 50M - 100M visitors per month


Based on our best estimate, this website will receive around 80,473,390 visitors per month in the current month.

check SE Ranking
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How Does Doi.org Make Money? {💸}

We can't tell how the site generates income.

Many websites are intended to earn money, but some serve to share ideas or build connections. Websites exist for all kinds of purposes. This might be one of them. Doi.org might have a hidden revenue stream, but it's not something we can detect.

Keywords {🔍}

google, scholar, article, cancer, cas, colorectal, journ, probiotic, probiotics, lactobacillus, kahouli, prakash, intestinal, pubmed, colon, res, malhotra, epithelial, model, cell, research, activity, effect, analysis, crc, bacteria, fermentum, cells, βcatenin, potential, medicine, acidophilus, apc, min, imen, alaouijamali, satya, effects, mice, clinic, sci, tomaroduchesneau, university, conflict, interest, privacy, cookies, content, orally, mouse,

Topics {✒️}

e-cadherin/β-catenin complex apc/β-catenin/tcf pathway month download article/chapter cadherin-catenin adhesion system bacterial driver–passenger model carrageenan-induced paw edema davis-jewish general hospital β-catenin tcf signaling 3755 côte-ste-catherine road probiotic bacillus polyfermenticus increased β-catenin expression bacteria-induced intestinal cancer β-catenin gene article applied microbiology epithelial barrier function apc gene product including β-catenin epithelial cell polarity de pascual-teresa cytosolic β-catenin activated β-catenin epithelial cell culture privacy choices/manage cookies probiotic lactobacillus gg full article pdf programmed cell death acidophilus probiotic formulation lactobacillus reuteri strains nf-κb pathway susan westfall declares probiotic propionibacterium freudenreichii lactobacillus acidophilus combined lactobacillus fermentum attenuates lactobacillus fermentum strains lactobacillus plantarum a7 oral lactobacillus isolates satya prakash declares normal cells proliferation 3175 cote-ste-catherine dss-induced colitis justine research center human epithelial cells intestinal tumor formation colorectal cancer progression alaoui-jamali declares lactic acid bacteria salah azaiz institute aloui-jamali ma alaoui-jamali department intestinal immune responses

Questions {❓}

  • Belcheva A, Irrazabal T, Martin A (2015) Gut microbial metabolism and colon cancer: can manipulations of the microbiota be useful in the management of gastrointestinal health?

Schema {🗺️}

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         headline:Design and validation of an orally administrated active L. fermentum-L. acidophilus probiotic formulation using colorectal cancer Apc Min/+ mouse model
         description:Probiotics have been shown to have beneficial properties in attenuating the risk of colorectal cancer (CRC) development. However, functional evidence to support such effects for some probiotic bacteria are relatively unknown. Here, we document a significant antioxidant, anti-proliferative and pro-apoptotic activities of Lactobacillus acidophilus ATCC 314 and Lactobacillus fermentum NCIMB 5221 on CRC cells, particularly when used in combination (La-Lf). Furthermore, a superior synergistic activity on the inhibition of tumor growth and modulation of cell proliferation and epithelial markers in the Apc Min/+ CRC mouse model was explored, based on the expression levels of Ki-67, E-cadherin, β-catenin, and cleaved caspase-3 (CC3) proteins. The anti-cancer activity of La-Lf co-culture was significantly enhanced in vitro with significant reduced proliferation (38.8 ± 6.9 %, P = 0.009) and increased apoptosis (413 RUL, P < 0.001) towards cancer cells, as well as significant protection of normal colon cell growth from toxic treatment (18.6 ± 9.8 %, P = 0.001). La-Lf formulation (1010cfu/animal/day) altered aspects of intestinal tumorigenesis by significantly reducing intestinal tumor multiplicity (1.7-fold, P = 0.016) and downregulating cellular proliferation markers, including β-catenin (P = 0.041) and Ki-67 (P = 0.008). In conclusion, La-Lf showed greater protection against intestinal tumorigenesis supporting a potential use as a biotherapeutic for the prevention of CRC.
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      headline:Design and validation of an orally administrated active L. fermentum-L. acidophilus probiotic formulation using colorectal cancer Apc Min/+ mouse model
      description:Probiotics have been shown to have beneficial properties in attenuating the risk of colorectal cancer (CRC) development. However, functional evidence to support such effects for some probiotic bacteria are relatively unknown. Here, we document a significant antioxidant, anti-proliferative and pro-apoptotic activities of Lactobacillus acidophilus ATCC 314 and Lactobacillus fermentum NCIMB 5221 on CRC cells, particularly when used in combination (La-Lf). Furthermore, a superior synergistic activity on the inhibition of tumor growth and modulation of cell proliferation and epithelial markers in the Apc Min/+ CRC mouse model was explored, based on the expression levels of Ki-67, E-cadherin, β-catenin, and cleaved caspase-3 (CC3) proteins. The anti-cancer activity of La-Lf co-culture was significantly enhanced in vitro with significant reduced proliferation (38.8 ± 6.9 %, P = 0.009) and increased apoptosis (413 RUL, P < 0.001) towards cancer cells, as well as significant protection of normal colon cell growth from toxic treatment (18.6 ± 9.8 %, P = 0.001). La-Lf formulation (1010cfu/animal/day) altered aspects of intestinal tumorigenesis by significantly reducing intestinal tumor multiplicity (1.7-fold, P = 0.016) and downregulating cellular proliferation markers, including β-catenin (P = 0.041) and Ki-67 (P = 0.008). In conclusion, La-Lf showed greater protection against intestinal tumorigenesis supporting a potential use as a biotherapeutic for the prevention of CRC.
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      name:Lady Davis Institute for Medical Research and Segal Cancer Centre, Sir Mortimer B. Davis-Jewish General Hospital, Montreal, Canada
      name:Department of Biomedical Engineering, Faculty of Medicine, Biomedical Technology and Cell Therapy Research Laboratory, McGill University, Montreal, Canada
      name:Department of Microbiology, Immunology and Infectious Diseases, CHU St. Justine Research Center, University of Montreal, Montréal, Canada
      name:Department of Biomedical Engineering, Faculty of Medicine, Biomedical Technology and Cell Therapy Research Laboratory, McGill University, Montreal, Canada
      name:Lady Davis Institute for Medical Research and Segal Cancer Centre, Sir Mortimer B. Davis-Jewish General Hospital, Montreal, Canada
      name:Departments of Medicine and Oncology, Faculty of Medicine, Gerald Bronfman Centre, McGill University, Montreal, Canada
      name:Department of Experimental Medicine, Faculty of Medicine, McGill University, Montreal, Canada
      name:Department of Biomedical Engineering, Faculty of Medicine, Biomedical Technology and Cell Therapy Research Laboratory, McGill University, Montreal, Canada
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