We are analyzing https://link.springer.com/article/10.1007/s10620-008-0363-2.

Title:
Estimation of the Potential Antitumor Activity of Microencapsulated Lactobacillus acidophilus Yogurt Formulation in the Attenuation of Tumorigenesis in Apc(Min/+) Mice | Digestive Diseases and Sciences
Description:
There is a strong correlation between orally administered probiotics and suppression of the low-grade inflammation that can lead to restoration of normal local immune functions. We studied the potential immunomodulatory and antitumorigenic properties of microencapsulated probiotic bacterial cells in a yogurt formulation in Min mice carrying a germline APC mutation. Daily oral administration of microencapsulated Lactobacillus acidophilus bacterial cells in the yogurt formulation mice resulted in significant suppression of colon tumor incidence, tumor multiplicity, and reduced tumor size. Results show that oral administration of microencapsulated L. acidophilus contributed to the stabilization of animal body weight and decreased the release of bile acids. Histopathological analyses revealed fewer adenomas in treated versus untreated animals. Furthermore, treated animals exhibited fewer gastrointestinal intra-epithelial neoplasias with a lower grade of dysplasia in detected tumors. Results suggest that oral administration of microencapsulated probiotic L. acidophilus exerts anti-tumorous activity, which consequently leads to reduced tumor outcome.
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Keywords {🔍}

google, scholar, pubmed, article, cas, cancer, interleukin, bile, lactobacillus, mice, acidophilus, activity, microencapsulated, yogurt, cells, colon, research, bhathena, prakash, probiotic, acids, dis, res, sci, urbanska, martoni, oral, administration, access, acid, bowel, cell, serum, university, privacy, cookies, content, formulation, satya, immune, min, tumor, model, perdigon, bacteria, effects, clin, food, gastroenterol, disease,

Topics {✒️}

short-chain fructo-oligosaccharides reduce month download article/chapter christopher martoni & satya prakash dss-induced ulcerative colitis transcription factors nf-kb enzyme-linked immunosorbent assay hepatic acute-phase response article digestive diseases fecal bile acid acidophilus probiotic formulation epithelial ovarian cancer total bile acids free bile acids full article pdf signal orchestration model inflammatory bowel disease lactobacillus acidophilus combined metastatic breast carcinoma related subjects experimental colorectal cancer hereditary colorectal cancer fecal sample collection privacy choices/manage cookies lactic acid bacteria colon tumor incidence daily oral administration bile salt hydrolase live bacterial cells organ research center check access instant access engineering research council microencapsulated recombinant cells article urbanska irritable bowel syndrome satya prakash feeding fermented milks min mouse graduate studentship award potential antitumor activity pancreatic islet cells bile acids colon cancer rat model lactobacillus acidophilus mcgill cancer center nutr sci vitaminol european economic area animal body weight orally administrated active

Questions {❓}

Moayyedi P, Achkar E (2006) Does fecal occult blood testing really reduce mortality?

Schema {🗺️}

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         description:There is a strong correlation between orally administered probiotics and suppression of the low-grade inflammation that can lead to restoration of normal local immune functions. We studied the potential immunomodulatory and antitumorigenic properties of microencapsulated probiotic bacterial cells in a yogurt formulation in Min mice carrying a germline APC mutation. Daily oral administration of microencapsulated Lactobacillus acidophilus bacterial cells in the yogurt formulation mice resulted in significant suppression of colon tumor incidence, tumor multiplicity, and reduced tumor size. Results show that oral administration of microencapsulated L. acidophilus contributed to the stabilization of animal body weight and decreased the release of bile acids. Histopathological analyses revealed fewer adenomas in treated versus untreated animals. Furthermore, treated animals exhibited fewer gastrointestinal intra-epithelial neoplasias with a lower grade of dysplasia in detected tumors. Results suggest that oral administration of microencapsulated probiotic L. acidophilus exerts anti-tumorous activity, which consequently leads to reduced tumor outcome.
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      headline:Estimation of the Potential Antitumor Activity of Microencapsulated Lactobacillus acidophilus Yogurt Formulation in the Attenuation of Tumorigenesis in Apc(Min/+) Mice
      description:There is a strong correlation between orally administered probiotics and suppression of the low-grade inflammation that can lead to restoration of normal local immune functions. We studied the potential immunomodulatory and antitumorigenic properties of microencapsulated probiotic bacterial cells in a yogurt formulation in Min mice carrying a germline APC mutation. Daily oral administration of microencapsulated Lactobacillus acidophilus bacterial cells in the yogurt formulation mice resulted in significant suppression of colon tumor incidence, tumor multiplicity, and reduced tumor size. Results show that oral administration of microencapsulated L. acidophilus contributed to the stabilization of animal body weight and decreased the release of bile acids. Histopathological analyses revealed fewer adenomas in treated versus untreated animals. Furthermore, treated animals exhibited fewer gastrointestinal intra-epithelial neoplasias with a lower grade of dysplasia in detected tumors. Results suggest that oral administration of microencapsulated probiotic L. acidophilus exerts anti-tumorous activity, which consequently leads to reduced tumor outcome.
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         Biochemistry
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