DOI . ORG {
}
We began analyzing https://link.springer.com/chapter/10.1007/978-3-319-78127-3_6, but it redirected us to https://link.springer.com/chapter/10.1007/978-3-319-78127-3_6. The analysis below is for the second page.
Title[redir]:
Stromal Cells in the Tumor Microenvironment | SpringerLink
Description:
The tumor microenvironment comprises a mass of heterogeneous cell types, including immune cells, endothelial cells, and fibroblasts, alongside cancer cells. It is increasingly becoming clear that the development of this support niche is critical to the continued...
Title[redir]:
Stromal Cells in the Tumor Microenvironment | SpringerLink
Description:
The tumor microenvironment comprises a mass of heterogeneous cell types, including immune cells, endothelial cells, and fibroblasts, alongside cancer cells. It is increasingly becoming clear that the development of this support niche is critical to the continued...
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Questions {❓}
- How does the extracellular matrix direct gene expression?
- Inflammation and cancer: back to Virchow?
Schema {🗺️}
ScholarlyArticle:
headline:Stromal Cells in the Tumor Microenvironment
pageEnd:114
pageStart:99
image:https://media.springernature.com/w153/springer-static/cover/book/978-3-319-78127-3.jpg
genre:
Biomedical and Life Sciences
Biomedical and Life Sciences (R0)
isPartOf:
name:Stromal Immunology
isbn:
978-3-319-78127-3
978-3-319-78125-9
type:Book
publisher:
name:Springer International Publishing
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Alice E. Denton
affiliation:
name:Babraham Institute
address:
name:Lymphocyte Signalling and Development, Babraham Institute, Cambridge, UK
type:PostalAddress
type:Organization
email:[email protected]
type:Person
name:Edward W. Roberts
affiliation:
name:University of California San Francisco
address:
name:Department of Pathology, University of California San Francisco, San Francisco, USA
type:PostalAddress
type:Organization
type:Person
name:Douglas T. Fearon
affiliation:
name:Cold Spring Harbor Laboratory, Weill Cornell Medical College
address:
name:Cold Spring Harbor Laboratory, Weill Cornell Medical College, New York, USA
type:PostalAddress
type:Organization
type:Person
keywords:Cancer-associated fibroblast, Tumor microenvironment, Stromal immunology, Immunotherapy
description:The tumor microenvironment comprises a mass of heterogeneous cell types, including immune cells, endothelial cells, and fibroblasts, alongside cancer cells. It is increasingly becoming clear that the development of this support niche is critical to the continued uncontrolled growth of the cancer. The tumor microenvironment contributes to the maintenance of cancer stemness and also directly promotes angiogenesis, invasion, metastasis, and chronic inflammation. In this chapter, we describe on the role of fibroblasts, specifically termed cancer-associated fibroblasts (CAFs), in the promotion and maintenance of cancers. CAFs have a multitude of effects on the growth and maintenance of cancer, and here we focus on their roles in modulating immune cells and responses; CAFs both inhibit immune cell access to the tumor microenvironment and inhibit their functions within the tumor. Finally, we describe the potential modulation of CAF function as an adjunct to bolster the effectiveness of cancer immunotherapies.
datePublished:2018
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PostalAddress:
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name:Department of Pathology, University of California San Francisco, San Francisco, USA
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