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We began analyzing https://link.springer.com/chapter/10.1007/978-3-319-50174-1_20, but it redirected us to https://link.springer.com/chapter/10.1007/978-3-319-50174-1_20. The analysis below is for the second page.

Title[redir]:
The Role of Sigma 1 Receptor as a Neuroprotective Target in Glaucoma | SpringerLink
Description:
The role of sigma 1 receptor (S1R) in glaucomaglaucoma is emerging as a promising field of study. Glaucoma is an optic neuropathy that shares common pathogenic mechanisms with other neurodegenerative diseases such as Alzheimer’s and Parkinson’s...

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Keywords {🔍}

pubmed, google, scholar, article, cas, sigma, receptor, central, glaucoma, cell, ophthalmol, retinal, sci, res, pharmacol, vis, invest, receptors, ganglion, cells, role, chapter, brain, augusta, stress, ligand, disease, neurodegeneration, exp, usa, bollinger, optic, mol, death, experimental, cellular, oxidative, eye, zhao, kathryn, phd, biology, signaling, activation, calcium, nerve, mice, neurosci, ther, pentazocine,

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month download article/chapter distinct structure-affinity relationship er-mitochondrion interface mediates detergent-resistant microdomains determine jing zhao & kathryn bollinger endoplasmic reticulum-mitochondria interface primary open-angle glaucoma endoplasmic reticulum-mitochondria junction extracellular-signal-regulated kinases 1/2 glun1/glun2a nmda receptor calcium-dependent intracellular mechanisms brain-derived neurotrophic factor mitochondrion-er-nucleus signaling rabbit iris-ciliary body independent glutamate-cystine exchanger extracellular signal-regulated kinase retinal ganglion cells sigma-1 receptor protects sigma-1 receptor stimulation raised intraocular pressure privacy choices/manage cookies receptor-selective ligands device instant download sigma-1 receptor ligands sigma receptor ligands intramural research program human lens cells sigma compounds derived glial cell interactions endoplasmic reticulum stress ocular hypotensive action sigma-1 receptor regulation sigma-1 receptor chaperones editor information editors sigma1 recognition sites sigma-1 receptor chaperone sigma receptor ligand chronic ocular hypertension selective sigma ligand chapter sigma receptors optic axon loss axon degeneration mechanisms optic nerve degeneration er stress responses nuclear factor kappab electron microscopy study randomized trial determines phase ii trial ligand binding site optic nerve early

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Francardo V (2014) Sigma-1 receptor: a potential new target for Parkinson’s disease?

Schema {🗺️}

ScholarlyArticle:
      headline:The Role of Sigma 1 Receptor as a Neuroprotective Target in Glaucoma
      pageEnd:307
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      keywords: Glaucoma , Optic nerve , Retinal ganglion cell , Neurodegeneration , Neuroprotection
      description:The role of sigma 1 receptor (S1R) in glaucomaglaucoma is emerging as a promising field of study. Glaucoma is an optic neuropathy that shares common pathogenic mechanisms with other neurodegenerative diseases such as Alzheimer’s and Parkinson’s diseaseParkinson’s disease . S1R modulates multiple cellular functions associated with neurodegenerationneurodegeneration . These include Ca2+ ion homeostasis, endoplasmic reticulum (ER) and oxidative stressoxidative stress , survival signaling pathways, neurotrophin secretion, and glial activation. S1R may also have neurorestorative properties including enhancement of neuronal plasticity and neurite outgrowth. Recent studies using agonistsAgonists for S1R within the eye provide hope that it could be a therapeutic target for glaucoma. Understanding the role of S1R in glaucoma may help us to stop the progression of this sight threatening disease.
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