We are analyzing https://link.springer.com/article/10.1007/s11033-012-1491-5.

Title:
Pregnenolone sulfate decreases intraocular pressure and changes expression of sigma receptor in a model of chronic ocular hypertension | Molecular Biology Reports
Description:
Sigma receptors are Ca2+-sensitive, ligand-operated receptor chaperones at the mitochondrion-associated endoplasmic reticulum membrane. This study describes the effect of the sigma receptor 1 agonist pregnenolone sulfate on intraocular pressure (IOP) and sigma receptor 1 expression in rat retinas after chronic ocular hypertension. Chronic ocular hypertension was induced by occlusion of episcleral veins. Retinal histological sections were obtained to determine inner plexiform layer thickness and the number of cell bodies in the ganglion cell layer. Sigma receptor expression in rat retinas was analyzed by RT-PCR and Western blotting. Cauterization caused IOP to increase >73%, and the pressure was maintained for 2 months. A time-dependent loss of ganglion cells and retinal thickness occurred at elevated IOP. High IOP decreased sigma receptor 1 expression during the first week, but expression was increased at 8 weeks. Injected pregnenolone significantly decreased IOP, prevented ganglion cell loss, protected inner plexiform layer thickness, and increased sigma receptor 1 expression in episcleral vein-cauterized rats. Sigma receptors appear to be neuroprotective and potential targets for glaucoma therapeutics.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Health & Fitness
Science

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We're unsure how the site profits.

Websites don't always need to be profitable; some serve as platforms for education or personal expression. Websites can serve multiple purposes. And this might be one of them. Link.springer.com could be getting rich in stealth mode, or the way it's monetizing isn't detectable.

Keywords {🔍}

sigma, article, receptor, google, scholar, pubmed, expression, cas, pressure, intraocular, chronic, ocular, hypertension, rat, glaucoma, access, privacy, cookies, content, model, sun, cheng, receptors, iop, retinal, cells, ophthalmol, res, ganapathy, information, publish, search, pregnenolone, xian, meng, yang, cell, ganglion, retina, invest, vis, sci, harbin, data, log, journal, research, sulfate, fang, huiping,

Topics {✒️}

month download article/chapter open-angle glaucoma estimated staurosporine-differentiated rgc-5 cells hydrogen peroxide-mediated death rabbit iris-ciliary body sigma-1 receptor-mediated mechanisms intraocular pressure lowering ligand-operated receptor chaperones episcleral vein-cauterized rats ganglion cell layer chronic ocular hypertension intraocular pressure full article pdf retinal muller cells privacy choices/manage cookies sigma1 recognition sites retinal histological sections retinal thickness occurred sigma-1 receptor chaperone decreasing glutamate accumulation sigma receptors regulating intracellular calcium huiping yuan sigma receptor expression sigma-1 receptor regulation time-dependent loss cauterization caused iop ganglion cells european economic area endoplasmic reticulum membrane plexiform layer thickness related subjects cross-sectional prevalence visual field damage gnana-prakasam jp 2nd affiliated hospital 3rd affiliated hospital article sun conditions privacy policy dimemorfan protects rats antiapoptotic molecule expression glaucoma therapeutics accepting optional cookies episcleral venous occlusion harbin medical university check access instant access article log sigma receptor mammalian retina

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Pregnenolone sulfate decreases intraocular pressure and changes expression of sigma receptor in a model of chronic ocular hypertension
         description:Sigma receptors are Ca2+-sensitive, ligand-operated receptor chaperones at the mitochondrion-associated endoplasmic reticulum membrane. This study describes the effect of the sigma receptor 1 agonist pregnenolone sulfate on intraocular pressure (IOP) and sigma receptor 1 expression in rat retinas after chronic ocular hypertension. Chronic ocular hypertension was induced by occlusion of episcleral veins. Retinal histological sections were obtained to determine inner plexiform layer thickness and the number of cell bodies in the ganglion cell layer. Sigma receptor expression in rat retinas was analyzed by RT-PCR and Western blotting. Cauterization caused IOP to increase >73%, and the pressure was maintained for 2 months. A time-dependent loss of ganglion cells and retinal thickness occurred at elevated IOP. High IOP decreased sigma receptor 1 expression during the first week, but expression was increased at 8 weeks. Injected pregnenolone significantly decreased IOP, prevented ganglion cell loss, protected inner plexiform layer thickness, and increased sigma receptor 1 expression in episcleral vein-cauterized rats. Sigma receptors appear to be neuroprotective and potential targets for glaucoma therapeutics.
         datePublished:2012-02-07T00:00:00Z
         dateModified:2012-02-07T00:00:00Z
         pageStart:6607
         pageEnd:6614
         sameAs:https://doi.org/10.1007/s11033-012-1491-5
         keywords:
            Sigma receptor 1
            Intraocular pressure
            Retinal ganglion cell
            Neuroprotection
            Glaucoma
            Animal Biochemistry
            Animal Anatomy / Morphology / Histology
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11033-012-1491-5/MediaObjects/11033_2012_1491_Fig1_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11033-012-1491-5/MediaObjects/11033_2012_1491_Fig2_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11033-012-1491-5/MediaObjects/11033_2012_1491_Fig3_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11033-012-1491-5/MediaObjects/11033_2012_1491_Fig4_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11033-012-1491-5/MediaObjects/11033_2012_1491_Fig5_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11033-012-1491-5/MediaObjects/11033_2012_1491_Fig6_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11033-012-1491-5/MediaObjects/11033_2012_1491_Fig7_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11033-012-1491-5/MediaObjects/11033_2012_1491_Fig8_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11033-012-1491-5/MediaObjects/11033_2012_1491_Fig9_HTML.gif
         isPartOf:
            name:Molecular Biology Reports
            issn:
               1573-4978
               0301-4851
            volumeNumber:39
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer Netherlands
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Xian Sun
               affiliation:
                     name:Harbin Medical University
                     address:
                        name:Key Laboratory of Ophthalmology, Department of Ophthalmology, The 2nd Affiliated Hospital, Harbin Medical University, Harbin, People’s Republic of China
                        type:PostalAddress
                     type:Organization
                     name:Harbin Medical University
                     address:
                        name:Department of Oncology, The 3rd Affiliated Hospital, Harbin Medical University, Harbin, People’s Republic of China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Fang Cheng
               affiliation:
                     name:Harbin Medical University
                     address:
                        name:Key Laboratory of Ophthalmology, Department of Ophthalmology, The 2nd Affiliated Hospital, Harbin Medical University, Harbin, People’s Republic of China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Bo Meng
               affiliation:
                     name:Harbin Medical University
                     address:
                        name:Key Laboratory of Ophthalmology, Department of Ophthalmology, The 2nd Affiliated Hospital, Harbin Medical University, Harbin, People’s Republic of China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Binbin Yang
               affiliation:
                     name:Harbin Medical University
                     address:
                        name:Key Laboratory of Ophthalmology, Department of Ophthalmology, The 2nd Affiliated Hospital, Harbin Medical University, Harbin, People’s Republic of China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Wulian Song
               affiliation:
                     name:Harbin Medical University
                     address:
                        name:Key Laboratory of Ophthalmology, Department of Ophthalmology, The 2nd Affiliated Hospital, Harbin Medical University, Harbin, People’s Republic of China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Huiping Yuan
               affiliation:
                     name:Harbin Medical University
                     address:
                        name:Key Laboratory of Ophthalmology, Department of Ophthalmology, The 2nd Affiliated Hospital, Harbin Medical University, Harbin, People’s Republic of China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Pregnenolone sulfate decreases intraocular pressure and changes expression of sigma receptor in a model of chronic ocular hypertension
      description:Sigma receptors are Ca2+-sensitive, ligand-operated receptor chaperones at the mitochondrion-associated endoplasmic reticulum membrane. This study describes the effect of the sigma receptor 1 agonist pregnenolone sulfate on intraocular pressure (IOP) and sigma receptor 1 expression in rat retinas after chronic ocular hypertension. Chronic ocular hypertension was induced by occlusion of episcleral veins. Retinal histological sections were obtained to determine inner plexiform layer thickness and the number of cell bodies in the ganglion cell layer. Sigma receptor expression in rat retinas was analyzed by RT-PCR and Western blotting. Cauterization caused IOP to increase >73%, and the pressure was maintained for 2 months. A time-dependent loss of ganglion cells and retinal thickness occurred at elevated IOP. High IOP decreased sigma receptor 1 expression during the first week, but expression was increased at 8 weeks. Injected pregnenolone significantly decreased IOP, prevented ganglion cell loss, protected inner plexiform layer thickness, and increased sigma receptor 1 expression in episcleral vein-cauterized rats. Sigma receptors appear to be neuroprotective and potential targets for glaucoma therapeutics.
      datePublished:2012-02-07T00:00:00Z
      dateModified:2012-02-07T00:00:00Z
      pageStart:6607
      pageEnd:6614
      sameAs:https://doi.org/10.1007/s11033-012-1491-5
      keywords:
         Sigma receptor 1
         Intraocular pressure
         Retinal ganglion cell
         Neuroprotection
         Glaucoma
         Animal Biochemistry
         Animal Anatomy / Morphology / Histology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11033-012-1491-5/MediaObjects/11033_2012_1491_Fig1_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11033-012-1491-5/MediaObjects/11033_2012_1491_Fig2_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11033-012-1491-5/MediaObjects/11033_2012_1491_Fig3_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11033-012-1491-5/MediaObjects/11033_2012_1491_Fig4_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11033-012-1491-5/MediaObjects/11033_2012_1491_Fig5_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11033-012-1491-5/MediaObjects/11033_2012_1491_Fig6_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11033-012-1491-5/MediaObjects/11033_2012_1491_Fig7_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11033-012-1491-5/MediaObjects/11033_2012_1491_Fig8_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11033-012-1491-5/MediaObjects/11033_2012_1491_Fig9_HTML.gif
      isPartOf:
         name:Molecular Biology Reports
         issn:
            1573-4978
            0301-4851
         volumeNumber:39
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer Netherlands
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Xian Sun
            affiliation:
                  name:Harbin Medical University
                  address:
                     name:Key Laboratory of Ophthalmology, Department of Ophthalmology, The 2nd Affiliated Hospital, Harbin Medical University, Harbin, People’s Republic of China
                     type:PostalAddress
                  type:Organization
                  name:Harbin Medical University
                  address:
                     name:Department of Oncology, The 3rd Affiliated Hospital, Harbin Medical University, Harbin, People’s Republic of China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Fang Cheng
            affiliation:
                  name:Harbin Medical University
                  address:
                     name:Key Laboratory of Ophthalmology, Department of Ophthalmology, The 2nd Affiliated Hospital, Harbin Medical University, Harbin, People’s Republic of China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Bo Meng
            affiliation:
                  name:Harbin Medical University
                  address:
                     name:Key Laboratory of Ophthalmology, Department of Ophthalmology, The 2nd Affiliated Hospital, Harbin Medical University, Harbin, People’s Republic of China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Binbin Yang
            affiliation:
                  name:Harbin Medical University
                  address:
                     name:Key Laboratory of Ophthalmology, Department of Ophthalmology, The 2nd Affiliated Hospital, Harbin Medical University, Harbin, People’s Republic of China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Wulian Song
            affiliation:
                  name:Harbin Medical University
                  address:
                     name:Key Laboratory of Ophthalmology, Department of Ophthalmology, The 2nd Affiliated Hospital, Harbin Medical University, Harbin, People’s Republic of China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Huiping Yuan
            affiliation:
                  name:Harbin Medical University
                  address:
                     name:Key Laboratory of Ophthalmology, Department of Ophthalmology, The 2nd Affiliated Hospital, Harbin Medical University, Harbin, People’s Republic of China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Molecular Biology Reports
      issn:
         1573-4978
         0301-4851
      volumeNumber:39
Organization:
      name:Springer Netherlands
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Harbin Medical University
      address:
         name:Key Laboratory of Ophthalmology, Department of Ophthalmology, The 2nd Affiliated Hospital, Harbin Medical University, Harbin, People’s Republic of China
         type:PostalAddress
      name:Harbin Medical University
      address:
         name:Department of Oncology, The 3rd Affiliated Hospital, Harbin Medical University, Harbin, People’s Republic of China
         type:PostalAddress
      name:Harbin Medical University
      address:
         name:Key Laboratory of Ophthalmology, Department of Ophthalmology, The 2nd Affiliated Hospital, Harbin Medical University, Harbin, People’s Republic of China
         type:PostalAddress
      name:Harbin Medical University
      address:
         name:Key Laboratory of Ophthalmology, Department of Ophthalmology, The 2nd Affiliated Hospital, Harbin Medical University, Harbin, People’s Republic of China
         type:PostalAddress
      name:Harbin Medical University
      address:
         name:Key Laboratory of Ophthalmology, Department of Ophthalmology, The 2nd Affiliated Hospital, Harbin Medical University, Harbin, People’s Republic of China
         type:PostalAddress
      name:Harbin Medical University
      address:
         name:Key Laboratory of Ophthalmology, Department of Ophthalmology, The 2nd Affiliated Hospital, Harbin Medical University, Harbin, People’s Republic of China
         type:PostalAddress
      name:Harbin Medical University
      address:
         name:Key Laboratory of Ophthalmology, Department of Ophthalmology, The 2nd Affiliated Hospital, Harbin Medical University, Harbin, People’s Republic of China
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Xian Sun
      affiliation:
            name:Harbin Medical University
            address:
               name:Key Laboratory of Ophthalmology, Department of Ophthalmology, The 2nd Affiliated Hospital, Harbin Medical University, Harbin, People’s Republic of China
               type:PostalAddress
            type:Organization
            name:Harbin Medical University
            address:
               name:Department of Oncology, The 3rd Affiliated Hospital, Harbin Medical University, Harbin, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Fang Cheng
      affiliation:
            name:Harbin Medical University
            address:
               name:Key Laboratory of Ophthalmology, Department of Ophthalmology, The 2nd Affiliated Hospital, Harbin Medical University, Harbin, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Bo Meng
      affiliation:
            name:Harbin Medical University
            address:
               name:Key Laboratory of Ophthalmology, Department of Ophthalmology, The 2nd Affiliated Hospital, Harbin Medical University, Harbin, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Binbin Yang
      affiliation:
            name:Harbin Medical University
            address:
               name:Key Laboratory of Ophthalmology, Department of Ophthalmology, The 2nd Affiliated Hospital, Harbin Medical University, Harbin, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Wulian Song
      affiliation:
            name:Harbin Medical University
            address:
               name:Key Laboratory of Ophthalmology, Department of Ophthalmology, The 2nd Affiliated Hospital, Harbin Medical University, Harbin, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Huiping Yuan
      affiliation:
            name:Harbin Medical University
            address:
               name:Key Laboratory of Ophthalmology, Department of Ophthalmology, The 2nd Affiliated Hospital, Harbin Medical University, Harbin, People’s Republic of China
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Key Laboratory of Ophthalmology, Department of Ophthalmology, The 2nd Affiliated Hospital, Harbin Medical University, Harbin, People’s Republic of China
      name:Department of Oncology, The 3rd Affiliated Hospital, Harbin Medical University, Harbin, People’s Republic of China
      name:Key Laboratory of Ophthalmology, Department of Ophthalmology, The 2nd Affiliated Hospital, Harbin Medical University, Harbin, People’s Republic of China
      name:Key Laboratory of Ophthalmology, Department of Ophthalmology, The 2nd Affiliated Hospital, Harbin Medical University, Harbin, People’s Republic of China
      name:Key Laboratory of Ophthalmology, Department of Ophthalmology, The 2nd Affiliated Hospital, Harbin Medical University, Harbin, People’s Republic of China
      name:Key Laboratory of Ophthalmology, Department of Ophthalmology, The 2nd Affiliated Hospital, Harbin Medical University, Harbin, People’s Republic of China
      name:Key Laboratory of Ophthalmology, Department of Ophthalmology, The 2nd Affiliated Hospital, Harbin Medical University, Harbin, People’s Republic of China
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(81)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.97s.

LINK . SPRINGER . COM {}