
DOI . ORG {
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Title[redir]:
Defense and Counterdefense in the RNAi-Based Antiviral Immune System in Insects | SpringerLink
Description:
RNA interference (RNAi) is an important pathway to combat virus infections in insects and plants. Hallmarks of antiviral RNAi in these organisms are: (1) an increase in virus replication after inactivation of major actors in the RNAi pathway, (2) production of...
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Keywords {π}
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Topics {βοΈ}
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ScholarlyArticle:
headline:Defense and Counterdefense in the RNAi-Based Antiviral Immune System in Insects
pageEnd:22
pageStart:3
image:https://media.springernature.com/w153/springer-static/cover/book/978-1-61779-037-9.jpg
genre:
Springer Protocols
isPartOf:
name:Antiviral RNAi
isbn:
978-1-61779-037-9
978-1-61779-036-2
type:Book
publisher:
name:Humana Press
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:JoΓ«l T. van Mierlo
affiliation:
type:Person
name:Koen W. R. van Cleef
affiliation:
type:Person
name:Ronald P. van Rij
affiliation:
name:Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Nijmegen Institute for Infection, Inflammation and Immunity
address:
name:Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Nijmegen Institute for Infection, Inflammation and Immunity, Nijmegen, The Netherlands
type:PostalAddress
type:Organization
email:[email protected]
type:Person
keywords:Viral suppressor of RNAi (VSR), RNA silencing, Insect antiviral immunity, Small RNA profiles, Insect virus
description:RNA interference (RNAi) is an important pathway to combat virus infections in insects and plants. Hallmarks of antiviral RNAi in these organisms are: (1) an increase in virus replication after inactivation of major actors in the RNAi pathway, (2) production of virus-derived small interfering RNAs (v-siRNAs), and (3) suppression of RNAi by dedicated viral proteins. In this chapter, we will review the mechanism of RNAi in insects, its function as an antiviral immune system, viral small RNA profiles, and viral counterdefense strategies. We will also consider alternative, inducible antiviral immune responses.
datePublished:2011
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isbn:
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type:ImageObject
name:Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Nijmegen Institute for Infection, Inflammation and Immunity
address:
name:Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Nijmegen Institute for Infection, Inflammation and Immunity, Nijmegen, The Netherlands
type:PostalAddress
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name:JoΓ«l T. van Mierlo
affiliation:
name:Koen W. R. van Cleef
affiliation:
name:Ronald P. van Rij
affiliation:
name:Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Nijmegen Institute for Infection, Inflammation and Immunity
address:
name:Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Nijmegen Institute for Infection, Inflammation and Immunity, Nijmegen, The Netherlands
type:PostalAddress
type:Organization
email:[email protected]
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name:Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Nijmegen Institute for Infection, Inflammation and Immunity, Nijmegen, The Netherlands
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