We are analyzing https://link.springer.com/article/10.1007/s11373-005-9058-2.

Title:
F-box proteins: the key to protein degradation | Journal of Biomedical Science
Description:
The eukaryotic protein degradation pathway involves the ubiquitin (Ub) modification of substrates targeted for degradation by the 26S proteasome. The addition of Ub, a process called ubiquitination, is mediated by enzymes including the E3 Ub ligases which transfer the Ub to targeted substrates. A major type of E3 Ub ligases, the SCF (Skp–Cullin–F-box) complex, is composed of four major components: Skp1, Cul1/Cdc53, Roc1/Rbx1/Hrt1, and an F-box protein. The F-box component of the SCF machineries is responsible for recognizing different substrates for ubiquitination. Interaction with components of the SCF complex is mediated through the F-box motif of the F-box protein while it associates with phosphorylated substrates through its second protein–protein interaction motif such as Trp–Asp (WD) repeats or leucine-rich repeats (LRRs). By targeting diverse substrates, F-box proteins exert controls over stability of proteins and regulate the mechanisms for a wide-range of cellular processes. Here we discuss the importance of F-box proteins by providing a general overview and examples of how F-box proteins function in various cellular settings such as tissue development, cell proliferation, and cell death, in the modeling organism Drosophila.
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Keywords {🔍}

article, google, scholar, pubmed, cas, cell, protein, drosophila, biol, fbox, ubiquitin, proteins, degradation, development, nature, ligases, scf, complex, nat, rev, curr, science, chien, ubiquitination, dev, mol, regulation, genes, slimb, apoptosis, privacy, cookies, journal, substrates, death, trends, molecular, regulates, cycle, cyclin, taiwan, function, content, publish, search, download, chengting, motif, role, pickart,

Topics {✒️}

f-box protein slimb/beta-trcp f-box/wd40-repeat protein slimb f-box e3-ubiquitin ligases cullin-ring ubiquitin ligases skp–cullin–f-box f-box protein slimb 26s proteasome scf ubiquitin-ligase complex tsai & cheng-ting chien achaete–scute gene complex f-box protein family mammalian f-box proteins f-box proteins function e3 ub ligases protein–protein interaction motif myc/max/mad network f-box protein cheng-ting chien f-box proteins archipelago regulates cyclin scf ubiquitin ligase f-box component protein closely related f-box motif protein degradation published /g1 cell-cycle transitions privacy choices/manage cookies morgue mediates apoptosis clock proteins period p27 regulates progression anaphase-promoting complex scffbw7 ubiquitin ligase drosophila nervous system process called ubiquitination phosphorylation-dependent ubiquitination drosophila clock gene protein recognition motif scf complex related subjects signal-induced ubiquitination drosophila follicle cells ubiquitin ligases targeted localized degradation leucine-rich repeat skp2-mediated degradation f-box biomedical science margaret protein ubiquitination mechanisms underlying ubiquitination cell death gene

Questions {❓}

Ubiquitin signalling: what’s in a chain?

Schema {🗺️}

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         headline:F-box proteins: the key to protein degradation
         description:The eukaryotic protein degradation pathway involves the ubiquitin (Ub) modification of substrates targeted for degradation by the 26S proteasome. The addition of Ub, a process called ubiquitination, is mediated by enzymes including the E3 Ub ligases which transfer the Ub to targeted substrates. A major type of E3 Ub ligases, the SCF (Skp–Cullin–F-box) complex, is composed of four major components: Skp1, Cul1/Cdc53, Roc1/Rbx1/Hrt1, and an F-box protein. The F-box component of the SCF machineries is responsible for recognizing different substrates for ubiquitination. Interaction with components of the SCF complex is mediated through the F-box motif of the F-box protein while it associates with phosphorylated substrates through its second protein–protein interaction motif such as Trp–Asp (WD) repeats or leucine-rich repeats (LRRs). By targeting diverse substrates, F-box proteins exert controls over stability of proteins and regulate the mechanisms for a wide-range of cellular processes. Here we discuss the importance of F-box proteins by providing a general overview and examples of how F-box proteins function in various cellular settings such as tissue development, cell proliferation, and cell death, in the modeling organism Drosophila.
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      headline:F-box proteins: the key to protein degradation
      description:The eukaryotic protein degradation pathway involves the ubiquitin (Ub) modification of substrates targeted for degradation by the 26S proteasome. The addition of Ub, a process called ubiquitination, is mediated by enzymes including the E3 Ub ligases which transfer the Ub to targeted substrates. A major type of E3 Ub ligases, the SCF (Skp–Cullin–F-box) complex, is composed of four major components: Skp1, Cul1/Cdc53, Roc1/Rbx1/Hrt1, and an F-box protein. The F-box component of the SCF machineries is responsible for recognizing different substrates for ubiquitination. Interaction with components of the SCF complex is mediated through the F-box motif of the F-box protein while it associates with phosphorylated substrates through its second protein–protein interaction motif such as Trp–Asp (WD) repeats or leucine-rich repeats (LRRs). By targeting diverse substrates, F-box proteins exert controls over stability of proteins and regulate the mechanisms for a wide-range of cellular processes. Here we discuss the importance of F-box proteins by providing a general overview and examples of how F-box proteins function in various cellular settings such as tissue development, cell proliferation, and cell death, in the modeling organism Drosophila.
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      name:Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan
      name:Institute of Molecular Medicine, Medical College, National Taiwan University, Taipei, Taiwan

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