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  1. Analyzed Page
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  3. CMS
  4. Monthly Traffic Estimate
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  6. Keywords
  7. Topics
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We began analyzing https://link.springer.com/protocol/10.1007/978-1-4939-7111-4_8, but it redirected us to https://link.springer.com/protocol/10.1007/978-1-4939-7111-4_8. The analysis below is for the second page.

Title[redir]:
Zymography as a Research Tool in the Study of Matrix Metalloproteinase Inhibitors | SpringerLink
Description:
Matrix metalloproteinases (MMPs) are proteolytic enzymes that degrade various components of the extracellular matrix (ECM) and play a role in tissue remodeling. Changes in MMPs have been observed in cancer, connective tissue disorders, and vascular disease, and both...

Matching Content Categories {📚}

  • Education
  • Science
  • Health & Fitness

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🏙️ Massive Traffic: 50M - 100M visitors per month


Based on our best estimate, this website will receive around 80,479,999 visitors per month in the current month.

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How Does Doi.org Make Money? {💸}

The income method remains a mystery to us.

While profit motivates many websites, others exist to inspire, entertain, or provide valuable resources. Websites have a variety of goals. And this might be one of them. Doi.org has a revenue plan, but it's either invisible or we haven't found it.

Keywords {🔍}

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Topics {✒️}

synthetic complementarity-determining-region diversity month download article/chapter x-ray absorption studies heparin-enhanced zymographic detection membrane-type-mmp rupp woessner jf jr cystatin/cysteine proteinase complexes acrylamide/bis-acrylamide ecm high-affinity human antibodies zymographic techniques peptide-based selective inhibitors matrix metalloproteinase-mediated activities facultad de ciencias small-cell lung cancer privacy choices/manage cookies de pascual-teresa device instant download activating peptide interleukin-8 dimensional gel electrophoresis matrix metalloproteinase inhibitor alpha 2-macroglobulin receptor neutralizing monoclonal antibody maizel jv jr human matrix metalloproteinase-2 catalytic zinc complex �cysteine switch” mechanism altered matrix metalloproteinase-2 van wart synthetic mmp inhibitors zinc metalloproteinase inhibitors matrix metalloproteinase inhibitors matrix-metalloproteinase inhibitors modulating mmp activity protein sequence analyses author information authors editor information editors specific peptide inhibitors sds-polyacrylamide gels european economic area additional helpful tips tanus-santos je gomis-ruth fx major jourden jl o'byrne kj malignant pleural effusions chronic allograft nephropathy lopresti-morrow ll structurally homologous metalloproteases combining donor-derived sodium dodecyl sulfate

Schema {🗺️}

ScholarlyArticle:
      headline:Zymography as a Research Tool in the Study of Matrix Metalloproteinase Inhibitors
      pageEnd:102
      pageStart:79
      image:https://media.springernature.com/w153/springer-static/cover/book/978-1-4939-7111-4.jpg
      genre:
         Springer Protocols
      isPartOf:
         name:Zymography
         isbn:
            978-1-4939-7111-4
            978-1-4939-7109-1
         type:Book
      publisher:
         name:Springer New York
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Zongli Ren
            affiliation:
                  name:Brigham and Women’s Hospital and Harvard Medical School
                  address:
                     name:Vascular Surgery Research Laboratory, Division of Vascular and Endovascular Surgery, Brigham and Women’s Hospital and Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Juanjuan Chen
            affiliation:
                  name:Brigham and Women’s Hospital and Harvard Medical School
                  address:
                     name:Vascular Surgery Research Laboratory, Division of Vascular and Endovascular Surgery, Brigham and Women’s Hospital and Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Raouf A. Khalil
            affiliation:
                  name:Brigham and Women’s Hospital and Harvard Medical School
                  address:
                     name:Vascular Surgery Research Laboratory, Division of Vascular and Endovascular Surgery, Brigham and Women’s Hospital and Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      keywords:Blood vessels, Uterus, Extracellular matrix, Matrix metalloproteinase, TIMP
      description:Matrix metalloproteinases (MMPs) are proteolytic enzymes that degrade various components of the extracellular matrix (ECM) and play a role in tissue remodeling. Changes in MMPs have been observed in cancer, connective tissue disorders, and vascular disease, and both endogenous tissue inhibitors of MMPs (TIMPs) and synthetic MMP inhibitors (MMPIs) have been evaluated as modulators of MMP activity in various biological systems. Zymography is a simple technique that is commonly used to assess MMP activity and the efficacy of MMPIs. Also, reverse zymography is a modified technique to study the activity of endogenous TIMPs. However, problems are often encountered during the zymography procedure, which could interfere with accurate assessment of MMP activity in control specimens, and thus make it difficult to determine the pathological changes in MMPs and their responsiveness to MMPIs. Simplified protocols for preparation of experimental solutions, tissue preparation, regular and reverse zymography procedures, and zymogram analysis are presented. Additional helpful tips to troubleshoot problems in the zymography technique and to enhance the quality of the zymograms should make it more feasible to determine the changes in MMPs and assess the efficacy of MMPIs in modulating MMP activity in various biological systems and pathological conditions.
      datePublished:2017
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Book:
      name:Zymography
      isbn:
         978-1-4939-7111-4
         978-1-4939-7109-1
Organization:
      name:Springer New York
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Brigham and Women’s Hospital and Harvard Medical School
      address:
         name:Vascular Surgery Research Laboratory, Division of Vascular and Endovascular Surgery, Brigham and Women’s Hospital and Harvard Medical School, Boston, USA
         type:PostalAddress
      name:Brigham and Women’s Hospital and Harvard Medical School
      address:
         name:Vascular Surgery Research Laboratory, Division of Vascular and Endovascular Surgery, Brigham and Women’s Hospital and Harvard Medical School, Boston, USA
         type:PostalAddress
      name:Brigham and Women’s Hospital and Harvard Medical School
      address:
         name:Vascular Surgery Research Laboratory, Division of Vascular and Endovascular Surgery, Brigham and Women’s Hospital and Harvard Medical School, Boston, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Zongli Ren
      affiliation:
            name:Brigham and Women’s Hospital and Harvard Medical School
            address:
               name:Vascular Surgery Research Laboratory, Division of Vascular and Endovascular Surgery, Brigham and Women’s Hospital and Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
      name:Juanjuan Chen
      affiliation:
            name:Brigham and Women’s Hospital and Harvard Medical School
            address:
               name:Vascular Surgery Research Laboratory, Division of Vascular and Endovascular Surgery, Brigham and Women’s Hospital and Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
      name:Raouf A. Khalil
      affiliation:
            name:Brigham and Women’s Hospital and Harvard Medical School
            address:
               name:Vascular Surgery Research Laboratory, Division of Vascular and Endovascular Surgery, Brigham and Women’s Hospital and Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Vascular Surgery Research Laboratory, Division of Vascular and Endovascular Surgery, Brigham and Women’s Hospital and Harvard Medical School, Boston, USA
      name:Vascular Surgery Research Laboratory, Division of Vascular and Endovascular Surgery, Brigham and Women’s Hospital and Harvard Medical School, Boston, USA
      name:Vascular Surgery Research Laboratory, Division of Vascular and Endovascular Surgery, Brigham and Women’s Hospital and Harvard Medical School, Boston, USA
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(295)

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