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ScholarlyArticle:
      headline:Citrus Flavonoids: A Review of Past Biological Activity Against Disease
      pageEnd:116
      pageStart:103
      image:https://media.springernature.com/w153/springer-static/cover/book/978-1-4615-5335-9.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Flavonoids in the Living System
         isbn:
            978-1-4615-5335-9
            978-1-4613-7434-3
         type:Book
      publisher:
         name:Springer US
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
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      author:
            name:Antonio Montanari
            affiliation:
                  name:Citrus Research and Education Center
                  address:
                     name:State of Florida, Department of Citrus, Citrus Research and Education Center, Lake Alfred, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jie Chen
            affiliation:
                  name:Citrus Research and Education Center
                  address:
                     name:State of Florida, Department of Citrus, Citrus Research and Education Center, Lake Alfred, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Wilbur Widmer
            affiliation:
                  name:Citrus Research and Education Center
                  address:
                     name:State of Florida, Department of Citrus, Citrus Research and Education Center, Lake Alfred, USA
                     type:PostalAddress
                  type:Organization
            type:Person
      keywords:Human Breast Cancer Cell, Orange Juice, Grapefruit Juice, Methoxyl Group, Citrus Flavonoid
      description:Flavonoids are common in fruits and vegetables and many function as natural antioxidants, free radical scavengers, and may also chelate pro-oxidant metals, reducing their capacity to produce free radicals (Affany et al., 1987). It has been estimated that humans consume 1 gram per day of flavonoids (Kuhnau et al., 1976). The majority of citrus flavonoids are flavanones bound as glycosides (Figure 1). Hesperidin, a glycoside of hesperetin, is predominant in orange and tangerine, whereas naringin and narirutin, glycosides of naringenin, are most abundant in grapefruit. Eriocitrin and hesperidin are the predominate flavonoids found in lemon and lime. Some therapeutic effects have been reported for citrus flavanoids (Fisher et al., 1982). In 1936 citrus flavonoids were reported to decrease capillary fragility and improve blood flow and were actually labeled “Vitamin P” (Rusznyak and Szent-Györgyi, 1936). But further research failed to substantiate that abnormal capillary permeability was due to a deficiency in bioflavonoids. In 1950, the Federation of American Societies for Experimental Biology recommended that the term “Vitamin P”, which had been applied to flavanoids, be discontinued (Vickery et al., 1950).
      datePublished:1998
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Book:
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      isbn:
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      name:Springer US
      logo:
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         type:ImageObject
      name:Citrus Research and Education Center
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Person:
      name:Antonio Montanari
      affiliation:
            name:Citrus Research and Education Center
            address:
               name:State of Florida, Department of Citrus, Citrus Research and Education Center, Lake Alfred, USA
               type:PostalAddress
            type:Organization
      name:Jie Chen
      affiliation:
            name:Citrus Research and Education Center
            address:
               name:State of Florida, Department of Citrus, Citrus Research and Education Center, Lake Alfred, USA
               type:PostalAddress
            type:Organization
      name:Wilbur Widmer
      affiliation:
            name:Citrus Research and Education Center
            address:
               name:State of Florida, Department of Citrus, Citrus Research and Education Center, Lake Alfred, USA
               type:PostalAddress
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      name:State of Florida, Department of Citrus, Citrus Research and Education Center, Lake Alfred, USA
      name:State of Florida, Department of Citrus, Citrus Research and Education Center, Lake Alfred, USA
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