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Title:
Invasion promoter versus invasion suppressor molecules: the paradigm of E-cadherin | Molecular Biology Reports
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Metastasis determines cancer malignancy. Neoplastic cells metastasize through a multistep process of invasion. At each step, these cells create a dynamic micro-ecosystem in which the elements of the host are considered to paricipate actively invasion. Within such micro-ecosystems, invasion is believed to be governed by a balance between the activation of promoter (i-minus) and suppressor (i-plus) genes. Products of such genes regulate the expression of the invasive (I-plus) and the nonivasive (I-minus) phenotypes. Experimentsin vitro andin vivo, as well as observations on human cancers have put forward the cell-cell adhesion molecule E-cadherin (L-CAM; uvomorulin) as a regulator of epithelial organization and an invasion suppressor.
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google, scholar, pubmed, cell, cancer, van, biol, mareel, res, roy, takeichi, metastasis, invasion, article, bracke, vleminckx, vakaet, kemler, pathol, biology, access, behrens, birchmeier, nature, usa, development, press, rev, int, hirano, sci, privacy, cookies, content, research, molecular, gao, gumbiner, proc, natl, acad, hirohashi, publish, search, suppressor, ecadherin, marc, cells, open, eds,
Topics {βοΈ}
e-cadherin special issue month download article/chapter acta oto-rhino-laryngol molecular cell biology invasion suppressor l-cam paricipate actively invasion e-cadherin related subjects full article pdf molecular pathology published privacy choices/manage cookies epithelial organization extracellular vesicles mareel mm article mareel van putten wlj van moorselaar rja cancer metastasis rev european economic area cell biology 2 cell biology 3 van larebeke na de bruyne gk conditions privacy policy dynamic micro-ecosystem nelson wj basic research developmental biology neoplastic cells metastasize nasim mm accepting optional cookies article log suppressor kao l check access instant access molecular genetics journal finder publish promoter uvomorulin carter bs article cite van roy van roy invasion dunn rs thompson ad thiery jp trends cell biol
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headline:Invasion promoter versus invasion suppressor molecules: the paradigm of E-cadherin
description:Metastasis determines cancer malignancy. Neoplastic cells metastasize through a multistep process of invasion. At each step, these cells create a dynamic micro-ecosystem in which the elements of the host are considered to paricipate actively invasion. Within such micro-ecosystems, invasion is believed to be governed by a balance between the activation of promoter (i-minus) and suppressor (i-plus) genes. Products of such genes regulate the expression of the invasive (I-plus) and the nonivasive (I-minus) phenotypes. Experimentsin vitro andin vivo, as well as observations on human cancers have put forward the cell-cell adhesion molecule E-cadherin (L-CAM; uvomorulin) as a regulator of epithelial organization and an invasion suppressor.
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invasion
metastasis
cell adhesion
E-cadherin
L-CAM
uvomorulin
IGF-I
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headline:Invasion promoter versus invasion suppressor molecules: the paradigm of E-cadherin
description:Metastasis determines cancer malignancy. Neoplastic cells metastasize through a multistep process of invasion. At each step, these cells create a dynamic micro-ecosystem in which the elements of the host are considered to paricipate actively invasion. Within such micro-ecosystems, invasion is believed to be governed by a balance between the activation of promoter (i-minus) and suppressor (i-plus) genes. Products of such genes regulate the expression of the invasive (I-plus) and the nonivasive (I-minus) phenotypes. Experimentsin vitro andin vivo, as well as observations on human cancers have put forward the cell-cell adhesion molecule E-cadherin (L-CAM; uvomorulin) as a regulator of epithelial organization and an invasion suppressor.
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Animal Biochemistry
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