
DOI . ORG {
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Title[redir]:
Epigenetics in Autism and Other Neurodevelopmental Diseases | SpringerLink
Description:
Autism was previously thought to be caused by environmental factors. However, genetic factors are now considered to be more contributory to the pathogenesis of autism, based on the recent findings of mutations in the genes which encode synaptic molecules associated...
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ScholarlyArticle:
headline:Epigenetics in Autism and Other Neurodevelopmental Diseases
pageEnd:98
pageStart:91
image:https://media.springernature.com/w153/springer-static/cover/book/978-1-4614-0653-2.jpg
genre:
Biomedical and Life Sciences
Biomedical and Life Sciences (R0)
isPartOf:
name:Neurodegenerative Diseases
isbn:
978-1-4614-0653-2
978-1-4614-0652-5
type:Book
publisher:
name:Springer US
logo:
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type:ImageObject
type:Organization
author:
name:Kunio Miyake
affiliation:
name:University of Yamanashi
address:
name:Department of Epigenetics Medicine, Faculty of Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan
type:PostalAddress
type:Organization
type:Person
name:Takae Hirasawa
affiliation:
name:University of Yamanashi
address:
name:Department of Epigenetics Medicine, Faculty of Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan
type:PostalAddress
type:Organization
type:Person
name:Tsuyoshi Koide
affiliation:
name:National Institute of Genetics
address:
name:Department of Mouse Genomics Resource Laboratory, National Institute of Genetics, Shizuoka, Japan
type:PostalAddress
type:Organization
type:Person
name:Takeo Kubota
affiliation:
name:University of Yamanashi
address:
name:Department of Epigenetics Medicine, Faculty of Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan
type:PostalAddress
type:Organization
email:[email protected]
type:Person
keywords:Neurodegenerative Disease, Valproic Acid, Epigenetic Mechanism, Rett Syndrome, Angelman Syndrome
description:Autism was previously thought to be caused by environmental factors. However, genetic factors are now considered to be more contributory to the pathogenesis of autism, based on the recent findings of mutations in the genes which encode synaptic molecules associated with the communication between neurons. Epigenetic is a mechanism that controls gene expression without changing DNA sequence but by changing chromosomal histone modifications and its abnormality is associated with several neurodevelopmental diseases. Since epigenetic modifications are known to be affected by environmental factors such as nutrition, drugs and mental stress, autistic diseases are not only caused by congenital genetic defects, but may also be caused by environmental factors via epigenetic mechanism. In this chapter, we introduce autistic diseases caused by epigenetic failures and discuss epigenetic changes by environmental factors and discuss new treatments for neurodevelopmental diseases based on the recent epigenetic findings.
datePublished:2012
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name:Department of Epigenetics Medicine, Faculty of Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan
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name:Department of Mouse Genomics Resource Laboratory, National Institute of Genetics, Shizuoka, Japan
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type:PostalAddress
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name:Takae Hirasawa
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name:University of Yamanashi
address:
name:Department of Epigenetics Medicine, Faculty of Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan
type:PostalAddress
type:Organization
name:Tsuyoshi Koide
affiliation:
name:National Institute of Genetics
address:
name:Department of Mouse Genomics Resource Laboratory, National Institute of Genetics, Shizuoka, Japan
type:PostalAddress
type:Organization
name:Takeo Kubota
affiliation:
name:University of Yamanashi
address:
name:Department of Epigenetics Medicine, Faculty of Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan
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email:[email protected]
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name:Department of Epigenetics Medicine, Faculty of Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan
name:Department of Mouse Genomics Resource Laboratory, National Institute of Genetics, Shizuoka, Japan
name:Department of Epigenetics Medicine, Faculty of Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan
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- https://support.springernature.com/en/support/home's financial summary
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Analytics and Tracking {π}
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Libraries {π}
- Clipboard.js
Emails and Hosting {βοΈ}
Mail Servers:
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Name Servers:
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