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Title:
Epigenetics in Autism and Other Neurodevelopmental Diseases | SpringerLink
Description:
Autism was previously thought to be caused by environmental factors. However, genetic factors are now considered to be more contributory to the pathogenesis of autism, based on the recent findings of mutations in the genes which encode synaptic molecules associated...
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Postnatal neurodevelopmental diseases: meeting at the synapse?

Schema {🗺️}

ScholarlyArticle:
      headline:Epigenetics in Autism and Other Neurodevelopmental Diseases
      pageEnd:98
      pageStart:91
      image:https://media.springernature.com/w153/springer-static/cover/book/978-1-4614-0653-2.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Neurodegenerative Diseases
         isbn:
            978-1-4614-0653-2
            978-1-4614-0652-5
         type:Book
      publisher:
         name:Springer US
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
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      author:
            name:Kunio Miyake
            affiliation:
                  name:University of Yamanashi
                  address:
                     name:Department of Epigenetics Medicine, Faculty of Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Takae Hirasawa
            affiliation:
                  name:University of Yamanashi
                  address:
                     name:Department of Epigenetics Medicine, Faculty of Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Tsuyoshi Koide
            affiliation:
                  name:National Institute of Genetics
                  address:
                     name:Department of Mouse Genomics Resource Laboratory, National Institute of Genetics, Shizuoka, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Takeo Kubota
            affiliation:
                  name:University of Yamanashi
                  address:
                     name:Department of Epigenetics Medicine, Faculty of Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      keywords:Neurodegenerative Disease, Valproic Acid, Epigenetic Mechanism, Rett Syndrome, Angelman Syndrome
      description:Autism was previously thought to be caused by environmental factors. However, genetic factors are now considered to be more contributory to the pathogenesis of autism, based on the recent findings of mutations in the genes which encode synaptic molecules associated with the communication between neurons. Epigenetic is a mechanism that controls gene expression without changing DNA sequence but by changing chromosomal histone modifications and its abnormality is associated with several neurodevelopmental diseases. Since epigenetic modifications are known to be affected by environmental factors such as nutrition, drugs and mental stress, autistic diseases are not only caused by congenital genetic defects, but may also be caused by environmental factors via epigenetic mechanism. In this chapter, we introduce autistic diseases caused by epigenetic failures and discuss epigenetic changes by environmental factors and discuss new treatments for neurodevelopmental diseases based on the recent epigenetic findings.
      datePublished:2012
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         978-1-4614-0652-5
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      name:Springer US
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      name:University of Yamanashi
      address:
         name:Department of Epigenetics Medicine, Faculty of Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan
         type:PostalAddress
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      address:
         name:Department of Epigenetics Medicine, Faculty of Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan
         type:PostalAddress
      name:National Institute of Genetics
      address:
         name:Department of Mouse Genomics Resource Laboratory, National Institute of Genetics, Shizuoka, Japan
         type:PostalAddress
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Person:
      name:Kunio Miyake
      affiliation:
            name:University of Yamanashi
            address:
               name:Department of Epigenetics Medicine, Faculty of Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan
               type:PostalAddress
            type:Organization
      name:Takae Hirasawa
      affiliation:
            name:University of Yamanashi
            address:
               name:Department of Epigenetics Medicine, Faculty of Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan
               type:PostalAddress
            type:Organization
      name:Tsuyoshi Koide
      affiliation:
            name:National Institute of Genetics
            address:
               name:Department of Mouse Genomics Resource Laboratory, National Institute of Genetics, Shizuoka, Japan
               type:PostalAddress
            type:Organization
      name:Takeo Kubota
      affiliation:
            name:University of Yamanashi
            address:
               name:Department of Epigenetics Medicine, Faculty of Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan
               type:PostalAddress
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      email:[email protected]
PostalAddress:
      name:Department of Epigenetics Medicine, Faculty of Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan
      name:Department of Epigenetics Medicine, Faculty of Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan
      name:Department of Mouse Genomics Resource Laboratory, National Institute of Genetics, Shizuoka, Japan
      name:Department of Epigenetics Medicine, Faculty of Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan
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