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This computational analysis provides evidence that as many as 10% of human genes are targets for regulation by small RNA molecules called microRNAs.
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Keywords {🔍}
target, mirna, genes, targets, mirnas, view, article, sites, google, scholar, predicted, human, gene, conserved, protein, site, cell, mrna, table, regulation, sequences, rna, mrnas, sequence, conservation, fmrp, mouse, prediction, utr, number, microrna, mammalian, expression, utrs, experiments, binding, lin, micrornas, transcripts, rat, coding, set, methods, cleavage, mammals, fish, rules, elegans, regions, regulated,
Topics {✒️}
plos biology 3 human proliferative diseases computer systems support plos biol 2 plos biol 1 cookies plos small interfering rna publications small interfering rnas messenger ribonucleoprotein particle messenger ribonucleoprotein complexes rna-induced silencing complex global alignment protocol global alignment program open-access article distributed antibody-positioned rna amplification embryonic-stem-cell-specific mirna double-stranded rna directs precursor microrna-155/bic rna �protein serine/threonine kinase” �protein-tyrosine kinase activity” single-residue-pair match scores 3′ untranslated regions global discovery producing double-stranded rna 20–21-nt single-stranded rna micro-rna genes mir15 cleaved double-stranded rna double-stranded antiparallel duplex �ubiquitin-protein ligase activity fragile x-related protein mental retardation protein small rna profile rna-binding gene essential g-quartet-dependent recognition 3′-untranslated region rnai enzyme complex bind au-rich elements fragile x-related proteins lim/homeobox protein lhx9 pre-mirna stem loop g-rich quartet motifs include g-quartet patterns real-time rt-pcr double-stranded rna single-stranded rna retinoic-acid-induced cells rna-binding domains found prediction methods share single high-scoring site
Questions {❓}
- Are FMRP-bound messages enriched in predicted targets?
- Do specific miRNAs target particular functional groups?
- How Conserved in Evolution Are miRNA Targets?
- How Widespread Is the Regulation of Translation by miRNA?
- How do miRNAs pair with their target messages?
- What are the main differences between these three prediction methods?
- What do our results imply regarding the mechanism of action?
- What is missing?
- What proportion of all genes is regulated by miRNAs?
- Yart A, Mayeux P, Raynal P (2003) Gab1, SHP-2 and other novel regulators of Ras: Targets for anticancer drug discovery?
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