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NCBI . NLM . NIH . GOV {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Ncbi.nlm.nih.gov Make Money
  6. Keywords
  7. Topics
  8. Questions
  9. Social Networks
  10. External Links
  11. Analytics And Tracking
  12. Libraries
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  14. CDN Services

We began analyzing https://pmc.ncbi.nlm.nih.gov/articles/PMC7410488/, but it redirected us to https://pmc.ncbi.nlm.nih.gov/articles/PMC7410488/. The analysis below is for the second page.

Title[redir]:
The cytokine GDF15 signals through a population of brainstem cholecystokinin neurons to mediate anorectic signalling - PMC
Description:
The cytokine, GDF15, is produced in pathological states which cause cellular stress, including cancer. When over expressed, it causes dramatic weight reduction, suggesting a role in disease-related anorexia. Here, we demonstrate that the GDF15 ...

Matching Content Categories {📚}

  • Education
  • Science
  • Health & Fitness

Content Management System {📝}

What CMS is ncbi.nlm.nih.gov built with?

Custom-built

No common CMS systems were detected on Ncbi.nlm.nih.gov, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of ncbi.nlm.nih.gov audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
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How Does Ncbi.nlm.nih.gov Make Money? {💸}

We find it hard to spot revenue streams.

The purpose of some websites isn't monetary gain; they're meant to inform, educate, or foster collaboration. Everyone has unique reasons for building websites. This could be an example. Ncbi.nlm.nih.gov could be getting rich in stealth mode, or the way it's monetizing isn't detectable.

Keywords {🔍}

neurons, gdf, gfral, figure, doi, cck, mice, cells, google, scholar, pubmed, intake, antibody, food, weight, pmc, article, anorexia, pbn, free, nts, data, body, cisplatin, group, nucleus, receptor, mouse, cat, activated, study, effects, supplement, administration, day, animals, apnts, time, authors, results, experiments, cgrp, signalling, cancer, fos, cell, reagent, role, conditioned, significant,

Topics {✒️}

pmc beta search cre-dependent designer pro-caspase long-acting mic-1/gdf15 molecules funding information excitatory hindbrain-forebrain communication modulate information flow diet-induced obese mice gdnf-family receptor α le genest-saint-isle streptavidin-conjugated fluorophores diluted aav5-flex-tacasp3-tevp post hoc tukey test express corticotrophin-releasing hormone channel rhodopsin-assisted mapping 30-µm-thick coronal sections data availability statement decision letter activates gfralap/nts neurons relevant post-synaptic targets gfral post-synaptic neurons funding statement commit cckap/nts neurons free-floating sections tgf-β cytokine family aav8-hsyn-dio-mcherry human mic-1/gdf15 vary prolactin-releasing peptide neurons post hoc examination confirmed gdf15 activated gfral+ve/cck gfral-immunoreactive cell bodies 10-μm-thick tissue sections inflammation-induced central mediator license information pmcid platinum-based therapeutic drug data availability statements 23663785 sequence-based reagent control aav-mcherry responded superfamily cytokine mic-1/gdf15 central amygdala pkc-δ nag-1/gdf-15 prevents obesity cckap/nts neurons showed accompanying author responses gfral/cckap/nts neurons blocking gdf15/gfral signalling flex-tacasp3-tevp cancer-related anorexia/cachexia dual-fluorescence rnascope dual-label fluorescence funding acquisition post hoc comparisons

Questions {❓}

  • 2) Why is the Pica behavior performed in rats whereas all other experiments are performed in mice?
  • 4) Why do the authors study a loss of function of CCK neurons using two methods in Figure 4 (the Tobacco Etch Protease and CCK receptor antagonist), and then, when studying the effects of cisplatin, use a completely different method in Figure 5 (monoclonal antibody against GFRAL) to study GFRAL neurons instead of CCK neurons?
  • 5) Does the ablation of CCK-expressing cells in the AP/NTS cause long-term changes in food intake behavior?
  • 6) Figure 5G: the reduction in food intake by cisplatin in the presence of control Ab seems to be small and only significant at day 2 (?
  • Can the decrease in preference be considered as a place aversion, even though the animals still prefer the same side of the chamber?
  • Could the authors make a larger conclusion about the fact that there is no result of CCK neuron ablation in the absence of GDF15 administration?
  • Could the authors provide a Table with exact measurements across many animals to fully report the quantitative details of these experiments?
  • If 45% of GFRAL cells co-localize with CCK, then why does the Venn diagram in Supplementary Figure 1 imply that much more than 45% (looks like 2/3) co-localize?
  • Is the projection to the PBN the only one that mediates anorexia in response to GFRAL neuron activation?
  • What fraction of the GFRAL neurons are glutamatergic?
  • What is the molecular identity of the other half?
  • Wouldn't this experiment be relatively easy to perform in mice?

Social Networks {👍}(6)

External Links {🔗}(150)

Analytics and Tracking {📊}

  • Google Analytics
  • Google Analytics 4
  • Google Tag Manager

Libraries {📚}

  • Cash.js
  • jQuery
  • jQuery module (jquery-3.6.0)
  • Zoom.js

Emails and Hosting {✉️}

Mail Servers:

  • nihcesxway.hub.nih.gov
  • nihcesxway2.hub.nih.gov
  • nihcesxway3.hub.nih.gov
  • nihcesxway4.hub.nih.gov
  • nihcesxway5.hub.nih.gov

Name Servers:

  • dns1-ncbi.ncbi.nlm.nih.gov
  • dns2-ncbi.ncbi.nlm.nih.gov
  • lhcns1.nlm.nih.gov
  • lhcns2.nlm.nih.gov

CDN Services {📦}

  • Ncbi

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