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We began analyzing https://elifesciences.org/articles/55164v2/peer-reviews, but it redirected us to https://elifesciences.org/articles/55164v2/peer-reviews. The analysis below is for the second page.

Title[redir]:
Peer review in The cytokine GDF15 signals through a population of brainstem cholecystokinin neurons to mediate anorectic signalling | eLife
Description:
The GDF15 receptor, GFRAL,is expressed on a unique population of brainstem CCK neurons and mediates pathophysiological anorexia.

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Keywords {🔍}

neurons, cck, gfral, gdf, figure, authors, mice, anorexia, cells, study, data, experiments, pbn, effects, results, paper, side, receptor, food, time, supplementary, article, reviewer, signaling, important, half, cgrp, intake, experiment, show, brainstem, effect, section, elife, response, cisplatin, express, included, ablation, aversion, antagonist, nts, conclusion, colocalize, published, fos, provide, number, chamber, united,

Topics {✒️}

channel rhodopsin-assisted mapping relevant post-synaptic targets gfral post-synaptic neurons single-cell rna-seq peer review elife sciences publications accompanying author responses cancer-treatment drug depends sa1 author response calca-cre mouse injected pbn-projecting cck neurons cre-dependent aav-caspase conditioned taste aversion decision letter mediate anorectic signalling alerts contact terms conditioned place aversion worthrosemary shoopkatie tyeclaire feethamgiuseppe d'agostinogarron original publishing model substantive revision requests tobacco etch protease trust interpretation based permitting “unforced choice making accurate weighing permitting unforced choice stock corporation incorporated leaky cre-expression endogenous gene expression cancer therapeutic drug united states richard gdf15 activates fos reference manager tools monoclonal antibody attenuates lilly research laboratories remaining gfral neurons cgrp-expressing neurons predominantly cck-ergic gfral neuron activation search alerts submit test conditions animals alter food intake reduce food intake cumulative food intake signaling peripheral threats concerns dampen enthusiasm inactivating cgrp neurons cck-expressing neurons cck expressing neurons gfral-expressing neurons

Questions {❓}

2) Why is the Pica behavior performed in rats whereas all other experiments are performed in mice?
4) Why do the authors study a loss of function of CCK neurons using two methods in Figure 4 (the Tobacco Etch Protease and CCK receptor antagonist), and then, when studying the effects of cisplatin, use a completely different method in Figure 5 (monoclonal antibody against GFRAL) to study GFRAL neurons instead of CCK neurons?
5) Does the ablation of CCK-expressing cells in the AP/NTS cause long-term changes in food intake behavior?
6) Figure 5G: the reduction in food intake by cisplatin in the presence of control Ab seems to be small and only significant at day 2 (?
Can the decrease in preference be considered as a place aversion, even though the animals still prefer the same side of the chamber?
Could the authors make a larger conclusion about the fact that there is no result of CCK neuron ablation in the absence of GDF15 administration?
Could the authors provide a Table with exact measurements across many animals to fully report the quantitative details of these experiments?
If 45% of GFRAL cells co-localize with CCK, then why does the Venn diagram in Supplementary Figure 1 imply that much more than 45% (looks like 2/3) co-localize?
Is the projection to the PBN the only one that mediates anorexia in response to GFRAL neuron activation?
What fraction of the GFRAL neurons are glutamatergic?
What is the molecular identity of the other half?
Wouldn't this experiment be relatively easy to perform in mice?

Schema {🗺️}

ScholarlyArticle:
      context:https://schema.org
      mainEntityOfPage:
         type:WebPage
         id:https://elifesciences.org/articles/55164
      headline:The cytokine GDF15 signals through a population of brainstem cholecystokinin neurons to mediate anorectic signalling
      datePublished:2020-07-29
      author:
            type:Person
            name:Amy A Worth
            type:Person
            name:Rosemary Shoop
            type:Person
            name:Katie Tye
            type:Person
            name:Claire H Feetham
            type:Person
            name:Giuseppe D'Agostino
            type:Person
            name:Garron T Dodd
            type:Person
            name:Frank Reimann
            type:Person
            name:Fiona M Gribble
            type:Person
            name:Emily C Beebe
            type:Person
            name:James D Dunbar
            type:Person
            name:Jesline T Alexander-Chacko
            type:Person
            name:Dana K Sindelar
            type:Person
            name:Tamer Coskun
            type:Person
            name:Paul J Emmerson
            type:Person
            name:Simon M Luckman
      publisher:
         type:Organization
         name:eLife Sciences Publications, Ltd
         logo:
            type:ImageObject
            url:https://elifesciences.org/assets/patterns/img/patterns/organisms/[email protected]
      keywords:
         GDF15
         GFRAL
         CCK
         food intake
         brainstem
         cisplatin
      about:
         Neuroscience
      description:The GDF15 receptor, GFRAL,is expressed on a unique population of brainstem CCK neurons and mediates pathophysiological anorexia.
      isPartOf:
         type:Periodical
         name:eLife
         issn:2050-084X
WebPage:
      id:https://elifesciences.org/articles/55164
Person:
      name:Amy A Worth
      name:Rosemary Shoop
      name:Katie Tye
      name:Claire H Feetham
      name:Giuseppe D'Agostino
      name:Garron T Dodd
      name:Frank Reimann
      name:Fiona M Gribble
      name:Emily C Beebe
      name:James D Dunbar
      name:Jesline T Alexander-Chacko
      name:Dana K Sindelar
      name:Tamer Coskun
      name:Paul J Emmerson
      name:Simon M Luckman
Organization:
      name:eLife Sciences Publications, Ltd
      logo:
         type:ImageObject
         url:https://elifesciences.org/assets/patterns/img/patterns/organisms/[email protected]
ImageObject:
      url:https://elifesciences.org/assets/patterns/img/patterns/organisms/[email protected]
Periodical:
      name:eLife
      issn:2050-084X

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