DOI . ORG {}

Analyzed Page
Matching Content Categories
CMS
Monthly Traffic Estimate
How Does Doi.org Make Money
Keywords
Topics
Schema
Social Networks
External Links
Analytics And Tracking
Libraries
Hosting Providers
CDN Services

We began analyzing https://www.nature.com/articles/ncomms11905, but it redirected us to https://www.nature.com/articles/ncomms11905. The analysis below is for the second page.

Title[redir]:
Genetically and functionally defined NTS to PBN brain circuits mediating anorexia | Nature Communications
Description:
The central nervous system controls food consumption to maintain metabolic homoeostasis. In response to a meal, visceral signals from the gut activate neurons in the nucleus of the solitary tract (NTS) via the vagus nerve. These NTS neurons then excite brain regions known to mediate feeding behaviour, such as the lateral parabrachial nucleus (PBN). We previously described a neural circuit for appetite suppression involving calcitonin gene-related protein (CGRP)-expressing PBN (CGRPPBN) neurons; however, the molecular identity of the inputs to these neurons was not established. Here we identify cholecystokinin (CCK) and noradrenergic, dopamine β-hydroxylase (DBH)-expressing NTS neurons as two separate populations that directly excite CGRPPBN neurons. When these NTS neurons are activated using optogenetic or chemogenetic methods, food intake decreases and with chronic stimulation mice lose body weight. Our optogenetic results reveal that CCK and DBH neurons in the NTS directly engage CGRPPBN neurons to promote anorexia. Neurons in the nucleus of the solitary tract (NTS) are known to receive visceral signals from the gut during feeding. Here, the authors identify two populations of CCK- and DBH-expressing NTS neurons that work to suppress food intake when activated via opto- or chemogenetic stimulation.

Matching Content Categories {📚}

Science
Pets
Education

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Doi.org Make Money? {💸}

The income method remains a mystery to us.

While profit motivates many websites, others exist to inspire, entertain, or provide valuable resources. Websites have a variety of goals. And this might be one of them. Doi.org might be cashing in, but we can't detect the method they're using.

Keywords {🔍}

neurons, nts, article, food, dbhnts, google, scholar, mice, ccknts, cas, intake, pbn, cno, activation, cgrppbn, feeding, cck, nucleus, animals, brain, fig, fos, expressing, nature, lateral, data, expression, observed, injection, activated, cells, hmdq, injected, group, mcherry, cgrp, mouse, min, tract, stimulation, sections, rat, receptor, measured, light, solitary, parabrachial, inputs, control, projections,

Topics {✒️}

nature portfolio cre-dependent paav-hsyn-dio-hm3dq privacy policy research diets advertising circular open-field arena preserve g-protein signal-transduction chemogenetic tools knight nature donkey anti-goat igg social media cre-dependent aav1-dio-chr2 open-field arena 45 min nature 483 nature 503 nature 0/ reprints high-resolution single-cell imaging paav-ef1α-dio-synaptophysin cre recombinase-dependent adeno paav1-ef1α-dio-synaptophysin paav-ef1α-dio-chr2 hypothalamic agouti-related peptide paav-ef1α-dio-mcherry author information authors low-fos-expressing group based light-emitting diode illumination open-field test ice-cold cutting solution beta3-adrenoceptor polymorphisms relate system patch-clamp amplifier bio-serve dustless pellets injecting aav1-dio-synaptophysin control aav-dio-mcherry virus serotonin agonist-induced hypophagia brain cytokine-independent switch maintain metabolic homoeostasis ad libitum access long-term signals responding promote feeding-related disorders beta2-adrenoceptor polymorphisms relate tyrosine hydroxylase-positive cells pre-restriction body weight fibre optic cannulae allowed unrestricted access prolactin-releasing peptide-immunoreactivity open field maladaptive eating patterns high mg2+/ca2+ ratio protein-coupled receptors

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Genetically and functionally defined NTS to PBN brain circuits mediating anorexia
         description:The central nervous system controls food consumption to maintain metabolic homoeostasis. In response to a meal, visceral signals from the gut activate neurons in the nucleus of the solitary tract (NTS) via the vagus nerve. These NTS neurons then excite brain regions known to mediate feeding behaviour, such as the lateral parabrachial nucleus (PBN). We previously described a neural circuit for appetite suppression involving calcitonin gene-related protein (CGRP)-expressing PBN (CGRPPBN) neurons; however, the molecular identity of the inputs to these neurons was not established. Here we identify cholecystokinin (CCK) and noradrenergic, dopamine Î²-hydroxylase (DBH)-expressing NTS neurons as two separate populations that directly excite CGRPPBN neurons. When these NTS neurons are activated using optogenetic or chemogenetic methods, food intake decreases and with chronic stimulation mice lose body weight. Our optogenetic results reveal that CCK and DBH neurons in the NTS directly engage CGRPPBN neurons to promote anorexia. Neurons in the nucleus of the solitary tract (NTS) are known to receive visceral signals from the gut during feeding. Here, the authors identify two populations of CCK- and DBH-expressing NTS neurons that work to suppress food intake when activated via opto- or chemogenetic stimulation.
         datePublished:2016-06-15T00:00:00Z
         dateModified:2016-06-15T00:00:00Z
         pageStart:1
         pageEnd:11
         license:http://creativecommons.org/licenses/by/4.0/
         sameAs:https://doi.org/10.1038/ncomms11905
         keywords:
            Feeding behaviour
            Neural circuits
            Science
            Humanities and Social Sciences
            multidisciplinary
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms11905/MediaObjects/41467_2016_Article_BFncomms11905_Figa_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms11905/MediaObjects/41467_2016_Article_BFncomms11905_Fig1_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms11905/MediaObjects/41467_2016_Article_BFncomms11905_Fig2_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms11905/MediaObjects/41467_2016_Article_BFncomms11905_Fig3_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms11905/MediaObjects/41467_2016_Article_BFncomms11905_Fig4_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms11905/MediaObjects/41467_2016_Article_BFncomms11905_Fig5_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms11905/MediaObjects/41467_2016_Article_BFncomms11905_Fig6_HTML.jpg
         isPartOf:
            name:Nature Communications
            issn:
               2041-1723
            volumeNumber:7
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Nature Publishing Group UK
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Carolyn W. Roman
               affiliation:
                     name:University of Washington
                     address:
                        name:Department of Biochemistry, University of Washington, Seattle, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Victor A. Derkach
               affiliation:
                     name:University of Washington
                     address:
                        name:Department of Biochemistry, University of Washington, Seattle, USA
                        type:PostalAddress
                     type:Organization
                     name:Howard Hughes Medical Institute, University of Washington
                     address:
                        name:Howard Hughes Medical Institute, University of Washington, Seattle, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Richard D. Palmiter
               affiliation:
                     name:University of Washington
                     address:
                        name:Department of Biochemistry, University of Washington, Seattle, USA
                        type:PostalAddress
                     type:Organization
                     name:Howard Hughes Medical Institute, University of Washington
                     address:
                        name:Howard Hughes Medical Institute, University of Washington, Seattle, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Genetically and functionally defined NTS to PBN brain circuits mediating anorexia
      description:The central nervous system controls food consumption to maintain metabolic homoeostasis. In response to a meal, visceral signals from the gut activate neurons in the nucleus of the solitary tract (NTS) via the vagus nerve. These NTS neurons then excite brain regions known to mediate feeding behaviour, such as the lateral parabrachial nucleus (PBN). We previously described a neural circuit for appetite suppression involving calcitonin gene-related protein (CGRP)-expressing PBN (CGRPPBN) neurons; however, the molecular identity of the inputs to these neurons was not established. Here we identify cholecystokinin (CCK) and noradrenergic, dopamine Î²-hydroxylase (DBH)-expressing NTS neurons as two separate populations that directly excite CGRPPBN neurons. When these NTS neurons are activated using optogenetic or chemogenetic methods, food intake decreases and with chronic stimulation mice lose body weight. Our optogenetic results reveal that CCK and DBH neurons in the NTS directly engage CGRPPBN neurons to promote anorexia. Neurons in the nucleus of the solitary tract (NTS) are known to receive visceral signals from the gut during feeding. Here, the authors identify two populations of CCK- and DBH-expressing NTS neurons that work to suppress food intake when activated via opto- or chemogenetic stimulation.
      datePublished:2016-06-15T00:00:00Z
      dateModified:2016-06-15T00:00:00Z
      pageStart:1
      pageEnd:11
      license:http://creativecommons.org/licenses/by/4.0/
      sameAs:https://doi.org/10.1038/ncomms11905
      keywords:
         Feeding behaviour
         Neural circuits
         Science
         Humanities and Social Sciences
         multidisciplinary
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms11905/MediaObjects/41467_2016_Article_BFncomms11905_Figa_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms11905/MediaObjects/41467_2016_Article_BFncomms11905_Fig1_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms11905/MediaObjects/41467_2016_Article_BFncomms11905_Fig2_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms11905/MediaObjects/41467_2016_Article_BFncomms11905_Fig3_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms11905/MediaObjects/41467_2016_Article_BFncomms11905_Fig4_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms11905/MediaObjects/41467_2016_Article_BFncomms11905_Fig5_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms11905/MediaObjects/41467_2016_Article_BFncomms11905_Fig6_HTML.jpg
      isPartOf:
         name:Nature Communications
         issn:
            2041-1723
         volumeNumber:7
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Nature Publishing Group UK
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Carolyn W. Roman
            affiliation:
                  name:University of Washington
                  address:
                     name:Department of Biochemistry, University of Washington, Seattle, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Victor A. Derkach
            affiliation:
                  name:University of Washington
                  address:
                     name:Department of Biochemistry, University of Washington, Seattle, USA
                     type:PostalAddress
                  type:Organization
                  name:Howard Hughes Medical Institute, University of Washington
                  address:
                     name:Howard Hughes Medical Institute, University of Washington, Seattle, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Richard D. Palmiter
            affiliation:
                  name:University of Washington
                  address:
                     name:Department of Biochemistry, University of Washington, Seattle, USA
                     type:PostalAddress
                  type:Organization
                  name:Howard Hughes Medical Institute, University of Washington
                  address:
                     name:Howard Hughes Medical Institute, University of Washington, Seattle, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Nature Communications
      issn:
         2041-1723
      volumeNumber:7
Organization:
      name:Nature Publishing Group UK
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:University of Washington
      address:
         name:Department of Biochemistry, University of Washington, Seattle, USA
         type:PostalAddress
      name:University of Washington
      address:
         name:Department of Biochemistry, University of Washington, Seattle, USA
         type:PostalAddress
      name:Howard Hughes Medical Institute, University of Washington
      address:
         name:Howard Hughes Medical Institute, University of Washington, Seattle, USA
         type:PostalAddress
      name:University of Washington
      address:
         name:Department of Biochemistry, University of Washington, Seattle, USA
         type:PostalAddress
      name:Howard Hughes Medical Institute, University of Washington
      address:
         name:Howard Hughes Medical Institute, University of Washington, Seattle, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Carolyn W. Roman
      affiliation:
            name:University of Washington
            address:
               name:Department of Biochemistry, University of Washington, Seattle, USA
               type:PostalAddress
            type:Organization
      name:Victor A. Derkach
      affiliation:
            name:University of Washington
            address:
               name:Department of Biochemistry, University of Washington, Seattle, USA
               type:PostalAddress
            type:Organization
            name:Howard Hughes Medical Institute, University of Washington
            address:
               name:Howard Hughes Medical Institute, University of Washington, Seattle, USA
               type:PostalAddress
            type:Organization
      name:Richard D. Palmiter
      affiliation:
            name:University of Washington
            address:
               name:Department of Biochemistry, University of Washington, Seattle, USA
               type:PostalAddress
            type:Organization
            name:Howard Hughes Medical Institute, University of Washington
            address:
               name:Howard Hughes Medical Institute, University of Washington, Seattle, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Biochemistry, University of Washington, Seattle, USA
      name:Department of Biochemistry, University of Washington, Seattle, USA
      name:Howard Hughes Medical Institute, University of Washington, Seattle, USA
      name:Department of Biochemistry, University of Washington, Seattle, USA
      name:Howard Hughes Medical Institute, University of Washington, Seattle, USA

Social Networks {👍}(2)

External Links {🔗}(308)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Prism.js
Zoom.js

Emails and Hosting {✉️}

Mail Servers:

mx.zoho.eu
mx2.zoho.eu
mx3.zoho.eu

Name Servers:

josh.ns.cloudflare.com
zita.ns.cloudflare.com

CDN Services {📦}

Crossref

5.12s.