DOI . ORG {}

Analyzed Page
Matching Content Categories
CMS
Monthly Traffic Estimate
How Does Doi.org Make Money
Keywords
Topics
Questions
Schema
External Links
Analytics And Tracking
Libraries
Hosting Providers
CDN Services

We began analyzing https://link.springer.com/article/10.1007/s00109-010-0642-1, but it redirected us to https://link.springer.com/article/10.1007/s00109-010-0642-1. The analysis below is for the second page.

Title[redir]:
Methylation matters: binding of Ets-1 to the demethylated Foxp3 gene contributes to the stabilization of Foxp3 expression in regulatory T cells | Journal of Molecular Medicine
Description:
The forkhead-box protein P3 (Foxp3) is a key transcription factor for the development and suppressive activity of regulatory T cells (Tregs), a T cell subset critically involved in the maintenance of self-tolerance and prevention of over-shooting immune responses. However, the transcriptional regulation of Foxp3 expression remains incompletely understood. We have previously shown that epigenetic modifications in the CpG-rich Treg-specific demethylated region (TSDR) in the Foxp3 locus are associated with stable Foxp3 expression. We now demonstrate that the methylation state of the CpG motifs within the TSDR controls its transcriptional activity rather than a Treg-specific transcription factor network. By systematically mutating every CpG motif within the TSDR, we could identify four CpG motifs, which are critically determining the transcriptional activity of the TSDR and which serve as binding sites for essential transcription factors, such as CREB/ATF and NF-κB, which have previously been shown to bind to this element. The transcription factor Ets-1 was here identified as an additional molecular player that specifically binds to the TSDR in a demethylation-dependent manner in vitro. Disruption of the Ets-1 binding sites within the TSDR drastically reduced its transcriptional enhancer activity. In addition, we found Ets-1 bound to the demethylated TSDR in ex vivo isolated Tregs, but not to the methylated TSDR in conventional CD4+ T cells. We therefore propose that Ets-1 is part of a larger protein complex, which binds to the TSDR only in its demethylated state, thereby restricting stable Foxp3 expression to the Treg lineage.

Matching Content Categories {📚}

Science
Education
Law & Government

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🏙️ Massive Traffic: 50M - 100M visitors per month

Based on our best estimate, this website will receive around 98,426,998 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Doi.org Make Money? {💸}

The income method remains a mystery to us.

Not every website is profit-driven; some are created to spread information or serve as an online presence. Websites can be made for many reasons. This could be one of them. Doi.org might be making money, but it's not detectable how they're doing it.

Keywords {🔍}

foxp, tsdr, cells, expression, binding, transcription, activity, article, pubmed, google, scholar, ets, transcriptional, cas, luciferase, regulatory, factor, tregs, fig, enhancer, cpg, cell, methylation, dna, demethylated, conventional, reporter, promoter, sites, protein, immunol, performed, regulation, factors, murine, gene, motifs, vitro, assays, control, function, shown, methylated, values, data, molecular, stable, crebatf, nfκb, human,

Topics {✒️}

methyl-group donor s-adenosylmethionine early b-cell-specific mb-1 nf-κb-subunit c-rel binds tgf-β-inducible early gene-1 natural tregs = foxp3+cd25+cd4+cd8− nf-κb-subunit c-rel tgf-β-induced foxp3 expression pcpgl-cmv/ef1 vector [35] tgf-β-induced foxp3+ tregs specific pathogen-free conditions tsdr-foxpro-luc reporter vector pgl3-luciferase-reporter vector runt-related transcription factor-1 treg-specific demethylated region transforming growth factor-β cells = foxp3−cd25−cd4+cd8− fusion-fx7 imaging-system runx1-cbfbeta transcription complex forkhead-box protein p3 graft-versus-host disease [2] inter-species conservation plots highest inter-species conservation anti-cd4-fluorescein isothiocyanate cell-restricted dna methyltransferase-1 wilcoxon signed-rank test tgf-β-sensitive enhancer multi-component protein complex tgf-β-induced tregs site-specific mutagenesis resulting multi-step selection procedure transcription factors creb/atf foxp3-dependent developmental program single-stranded dna-oligonucleotides article download pdf 1 μg/ml anti-cd3 transcription factor repertoire anti-cd25-apc antibody nf-κb-binding site nf-κb binding site nf-κb binding sites distinct demethylation-dependent interactions 250 mm tris-hcl ph 8 cd4+cd25+foxp3gfp+ tregs full size image anti-fitc-multisort microbeads stat6-deficient inducible tgf-β-mediated signals human cd4+cd25+ regulatory 1 μg/ml anti-cd28 demethylating drug 5-aza-2′-deoxycytidine

Questions {❓}

A central question still remains to be solved: Which signals and pathways lead to the demethylation of the TSDR during differentiation into stable Tregs?
Huehn J, Polansky JK, Hamann A (2009) Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Methylation matters: binding of Ets-1 to the demethylated Foxp3 gene contributes to the stabilization of Foxp3 expression in regulatory T cells
         description:The forkhead-box protein P3 (Foxp3) is a key transcription factor for the development and suppressive activity of regulatory T cells (Tregs), a T cell subset critically involved in the maintenance of self-tolerance and prevention of over-shooting immune responses. However, the transcriptional regulation of Foxp3 expression remains incompletely understood. We have previously shown that epigenetic modifications in the CpG-rich Treg-specific demethylated region (TSDR) in the Foxp3 locus are associated with stable Foxp3 expression. We now demonstrate that the methylation state of the CpG motifs within the TSDR controls its transcriptional activity rather than a Treg-specific transcription factor network. By systematically mutating every CpG motif within the TSDR, we could identify four CpG motifs, which are critically determining the transcriptional activity of the TSDR and which serve as binding sites for essential transcription factors, such as CREB/ATF and NF-κB, which have previously been shown to bind to this element. The transcription factor Ets-1 was here identified as an additional molecular player that specifically binds to the TSDR in a demethylation-dependent manner in vitro. Disruption of the Ets-1 binding sites within the TSDR drastically reduced its transcriptional enhancer activity. In addition, we found Ets-1 bound to the demethylated TSDR in ex vivo isolated Tregs, but not to the methylated TSDR in conventional CD4+ T cells. We therefore propose that Ets-1 is part of a larger protein complex, which binds to the TSDR only in its demethylated state, thereby restricting stable Foxp3 expression to the Treg lineage.
         datePublished:2010-06-24T00:00:00Z
         dateModified:2010-06-24T00:00:00Z
         pageStart:1029
         pageEnd:1040
         license:https://creativecommons.org/licenses/by-nc/2.0
         sameAs:https://doi.org/10.1007/s00109-010-0642-1
         keywords:
            Epigenetic control
            DNA methylation
            Gene expression
            Transcription factors
            Molecular Medicine
            Human Genetics
            Internal Medicine
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00109-010-0642-1/MediaObjects/109_2010_642_Fig1_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00109-010-0642-1/MediaObjects/109_2010_642_Fig2_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00109-010-0642-1/MediaObjects/109_2010_642_Fig3_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00109-010-0642-1/MediaObjects/109_2010_642_Fig4_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00109-010-0642-1/MediaObjects/109_2010_642_Fig5_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00109-010-0642-1/MediaObjects/109_2010_642_Fig6_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00109-010-0642-1/MediaObjects/109_2010_642_Fig7_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00109-010-0642-1/MediaObjects/109_2010_642_Fig8_HTML.gif
         isPartOf:
            name:Journal of Molecular Medicine
            issn:
               1432-1440
               0946-2716
            volumeNumber:88
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer-Verlag
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Julia K. Polansky
               affiliation:
                     name:Helmholtz Centre for Infection Research
                     address:
                        name:Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
                        type:PostalAddress
                     type:Organization
                     name:Leibniz-Center for Medicine and Biosciences
                     address:
                        name:Immunobiology, Leibniz-Center for Medicine and Biosciences, Borstel, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Lisa Schreiber
               affiliation:
                     name:Helmholtz Centre for Infection Research
                     address:
                        name:Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Christoph Thelemann
               affiliation:
                     name:Charité University Medicine Berlin and German Rheumatism Research Center
                     address:
                        name:Experimental Rheumatology, Charité University Medicine Berlin and German Rheumatism Research Center, Berlin, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Leif Ludwig
               affiliation:
                     name:Charité University Medicine Berlin and German Rheumatism Research Center
                     address:
                        name:Experimental Rheumatology, Charité University Medicine Berlin and German Rheumatism Research Center, Berlin, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Melanie Krüger
               affiliation:
                     name:German Rheumatism Research Center
                     address:
                        name:Signal Transduction, German Rheumatism Research Center, Berlin, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Ria Baumgrass
               affiliation:
                     name:German Rheumatism Research Center
                     address:
                        name:Signal Transduction, German Rheumatism Research Center, Berlin, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Sascha Cording
               affiliation:
                     name:Helmholtz Centre for Infection Research
                     address:
                        name:Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Stefan Floess
               affiliation:
                     name:Helmholtz Centre for Infection Research
                     address:
                        name:Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Alf Hamann
               affiliation:
                     name:Charité University Medicine Berlin and German Rheumatism Research Center
                     address:
                        name:Experimental Rheumatology, Charité University Medicine Berlin and German Rheumatism Research Center, Berlin, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jochen Huehn
               affiliation:
                     name:Helmholtz Centre for Infection Research
                     address:
                        name:Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Methylation matters: binding of Ets-1 to the demethylated Foxp3 gene contributes to the stabilization of Foxp3 expression in regulatory T cells
      description:The forkhead-box protein P3 (Foxp3) is a key transcription factor for the development and suppressive activity of regulatory T cells (Tregs), a T cell subset critically involved in the maintenance of self-tolerance and prevention of over-shooting immune responses. However, the transcriptional regulation of Foxp3 expression remains incompletely understood. We have previously shown that epigenetic modifications in the CpG-rich Treg-specific demethylated region (TSDR) in the Foxp3 locus are associated with stable Foxp3 expression. We now demonstrate that the methylation state of the CpG motifs within the TSDR controls its transcriptional activity rather than a Treg-specific transcription factor network. By systematically mutating every CpG motif within the TSDR, we could identify four CpG motifs, which are critically determining the transcriptional activity of the TSDR and which serve as binding sites for essential transcription factors, such as CREB/ATF and NF-κB, which have previously been shown to bind to this element. The transcription factor Ets-1 was here identified as an additional molecular player that specifically binds to the TSDR in a demethylation-dependent manner in vitro. Disruption of the Ets-1 binding sites within the TSDR drastically reduced its transcriptional enhancer activity. In addition, we found Ets-1 bound to the demethylated TSDR in ex vivo isolated Tregs, but not to the methylated TSDR in conventional CD4+ T cells. We therefore propose that Ets-1 is part of a larger protein complex, which binds to the TSDR only in its demethylated state, thereby restricting stable Foxp3 expression to the Treg lineage.
      datePublished:2010-06-24T00:00:00Z
      dateModified:2010-06-24T00:00:00Z
      pageStart:1029
      pageEnd:1040
      license:https://creativecommons.org/licenses/by-nc/2.0
      sameAs:https://doi.org/10.1007/s00109-010-0642-1
      keywords:
         Epigenetic control
         DNA methylation
         Gene expression
         Transcription factors
         Molecular Medicine
         Human Genetics
         Internal Medicine
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00109-010-0642-1/MediaObjects/109_2010_642_Fig1_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00109-010-0642-1/MediaObjects/109_2010_642_Fig2_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00109-010-0642-1/MediaObjects/109_2010_642_Fig3_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00109-010-0642-1/MediaObjects/109_2010_642_Fig4_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00109-010-0642-1/MediaObjects/109_2010_642_Fig5_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00109-010-0642-1/MediaObjects/109_2010_642_Fig6_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00109-010-0642-1/MediaObjects/109_2010_642_Fig7_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00109-010-0642-1/MediaObjects/109_2010_642_Fig8_HTML.gif
      isPartOf:
         name:Journal of Molecular Medicine
         issn:
            1432-1440
            0946-2716
         volumeNumber:88
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer-Verlag
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Julia K. Polansky
            affiliation:
                  name:Helmholtz Centre for Infection Research
                  address:
                     name:Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
                     type:PostalAddress
                  type:Organization
                  name:Leibniz-Center for Medicine and Biosciences
                  address:
                     name:Immunobiology, Leibniz-Center for Medicine and Biosciences, Borstel, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Lisa Schreiber
            affiliation:
                  name:Helmholtz Centre for Infection Research
                  address:
                     name:Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Christoph Thelemann
            affiliation:
                  name:Charité University Medicine Berlin and German Rheumatism Research Center
                  address:
                     name:Experimental Rheumatology, Charité University Medicine Berlin and German Rheumatism Research Center, Berlin, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Leif Ludwig
            affiliation:
                  name:Charité University Medicine Berlin and German Rheumatism Research Center
                  address:
                     name:Experimental Rheumatology, Charité University Medicine Berlin and German Rheumatism Research Center, Berlin, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Melanie Krüger
            affiliation:
                  name:German Rheumatism Research Center
                  address:
                     name:Signal Transduction, German Rheumatism Research Center, Berlin, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ria Baumgrass
            affiliation:
                  name:German Rheumatism Research Center
                  address:
                     name:Signal Transduction, German Rheumatism Research Center, Berlin, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Sascha Cording
            affiliation:
                  name:Helmholtz Centre for Infection Research
                  address:
                     name:Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Stefan Floess
            affiliation:
                  name:Helmholtz Centre for Infection Research
                  address:
                     name:Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Alf Hamann
            affiliation:
                  name:Charité University Medicine Berlin and German Rheumatism Research Center
                  address:
                     name:Experimental Rheumatology, Charité University Medicine Berlin and German Rheumatism Research Center, Berlin, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jochen Huehn
            affiliation:
                  name:Helmholtz Centre for Infection Research
                  address:
                     name:Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Journal of Molecular Medicine
      issn:
         1432-1440
         0946-2716
      volumeNumber:88
Organization:
      name:Springer-Verlag
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Helmholtz Centre for Infection Research
      address:
         name:Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
         type:PostalAddress
      name:Leibniz-Center for Medicine and Biosciences
      address:
         name:Immunobiology, Leibniz-Center for Medicine and Biosciences, Borstel, Germany
         type:PostalAddress
      name:Helmholtz Centre for Infection Research
      address:
         name:Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
         type:PostalAddress
      name:Charité University Medicine Berlin and German Rheumatism Research Center
      address:
         name:Experimental Rheumatology, Charité University Medicine Berlin and German Rheumatism Research Center, Berlin, Germany
         type:PostalAddress
      name:Charité University Medicine Berlin and German Rheumatism Research Center
      address:
         name:Experimental Rheumatology, Charité University Medicine Berlin and German Rheumatism Research Center, Berlin, Germany
         type:PostalAddress
      name:German Rheumatism Research Center
      address:
         name:Signal Transduction, German Rheumatism Research Center, Berlin, Germany
         type:PostalAddress
      name:German Rheumatism Research Center
      address:
         name:Signal Transduction, German Rheumatism Research Center, Berlin, Germany
         type:PostalAddress
      name:Helmholtz Centre for Infection Research
      address:
         name:Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
         type:PostalAddress
      name:Helmholtz Centre for Infection Research
      address:
         name:Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
         type:PostalAddress
      name:Charité University Medicine Berlin and German Rheumatism Research Center
      address:
         name:Experimental Rheumatology, Charité University Medicine Berlin and German Rheumatism Research Center, Berlin, Germany
         type:PostalAddress
      name:Helmholtz Centre for Infection Research
      address:
         name:Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Julia K. Polansky
      affiliation:
            name:Helmholtz Centre for Infection Research
            address:
               name:Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
               type:PostalAddress
            type:Organization
            name:Leibniz-Center for Medicine and Biosciences
            address:
               name:Immunobiology, Leibniz-Center for Medicine and Biosciences, Borstel, Germany
               type:PostalAddress
            type:Organization
      name:Lisa Schreiber
      affiliation:
            name:Helmholtz Centre for Infection Research
            address:
               name:Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
               type:PostalAddress
            type:Organization
      name:Christoph Thelemann
      affiliation:
            name:Charité University Medicine Berlin and German Rheumatism Research Center
            address:
               name:Experimental Rheumatology, Charité University Medicine Berlin and German Rheumatism Research Center, Berlin, Germany
               type:PostalAddress
            type:Organization
      name:Leif Ludwig
      affiliation:
            name:Charité University Medicine Berlin and German Rheumatism Research Center
            address:
               name:Experimental Rheumatology, Charité University Medicine Berlin and German Rheumatism Research Center, Berlin, Germany
               type:PostalAddress
            type:Organization
      name:Melanie Krüger
      affiliation:
            name:German Rheumatism Research Center
            address:
               name:Signal Transduction, German Rheumatism Research Center, Berlin, Germany
               type:PostalAddress
            type:Organization
      name:Ria Baumgrass
      affiliation:
            name:German Rheumatism Research Center
            address:
               name:Signal Transduction, German Rheumatism Research Center, Berlin, Germany
               type:PostalAddress
            type:Organization
      name:Sascha Cording
      affiliation:
            name:Helmholtz Centre for Infection Research
            address:
               name:Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
               type:PostalAddress
            type:Organization
      name:Stefan Floess
      affiliation:
            name:Helmholtz Centre for Infection Research
            address:
               name:Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
               type:PostalAddress
            type:Organization
      name:Alf Hamann
      affiliation:
            name:Charité University Medicine Berlin and German Rheumatism Research Center
            address:
               name:Experimental Rheumatology, Charité University Medicine Berlin and German Rheumatism Research Center, Berlin, Germany
               type:PostalAddress
            type:Organization
      name:Jochen Huehn
      affiliation:
            name:Helmholtz Centre for Infection Research
            address:
               name:Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
      name:Immunobiology, Leibniz-Center for Medicine and Biosciences, Borstel, Germany
      name:Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
      name:Experimental Rheumatology, Charité University Medicine Berlin and German Rheumatism Research Center, Berlin, Germany
      name:Experimental Rheumatology, Charité University Medicine Berlin and German Rheumatism Research Center, Berlin, Germany
      name:Signal Transduction, German Rheumatism Research Center, Berlin, Germany
      name:Signal Transduction, German Rheumatism Research Center, Berlin, Germany
      name:Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
      name:Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
      name:Experimental Rheumatology, Charité University Medicine Berlin and German Rheumatism Research Center, Berlin, Germany
      name:Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany

External Links {🔗}(291)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

Emails and Hosting {✉️}

Mail Servers:

mx.zoho.eu
mx2.zoho.eu
mx3.zoho.eu

Name Servers:

josh.ns.cloudflare.com
zita.ns.cloudflare.com

CDN Services {📦}

Crossref

5.54s.