
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Single-cell RNA sequencing demonstrates the molecular and cellular reprogramming of metastatic lung adenocarcinoma - PMC
Description:
Advanced metastatic cancer poses utmost clinical challenges and may present molecular and cellular features distinct from an early-stage cancer. Herein, we present single-cell transcriptome profiling of metastatic lung adenocarcinoma, the most ...
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Keywords {🔍}
cells, cell, doi, tumor, fig, lung, samples, supplementary, pubmed, cancer, google, scholar, data, genes, pmc, article, tissues, free, expression, normal, luad, immune, singlecell, gene, subsets, tlung, tissue, primary, analysis, macrophages, mln, cellular, metastatic, progression, mbrain, momacs, tlb, epithelial, test, lymph, marker, clusters, exhausted, myeloid, interactions, metastases, malignant, nat, molecular, patients,
Topics {✒️}
pd-1/pd-l1 blockade immunotherapy single-cell rna-seq reveals multi-subunit ligand-receptor complexes single-cell rna-seq data raw gene-cell-barcode matrix anti-human epcam-percp/cy5 author contributions fitc-conjugated anti-human cd56 competing interests tumor-derived epcam−cd45− cells cd45+lin-hla-dr+ intra-patient genomic heterogeneity single-cell rna-sequencing single-cell rna sequencing force-directed layout algorithm code availability data availability statements inter-patient genomic heterogeneity 100-bp paired-end mode systemic multi-patient analyses paired single-cell analyses pmc beta search human b-cell lymphomas single-cell transcriptomic analysis early maternal-fetal interface quantile-normalized variance larger license information pmcid lilrb receptor-mediated regulation inferring cell-cell communication single-cell expression data induce erk-mapk signaling adjust cell-sampling biases gaining anti-inflammatory signatures quantile-normalized variance greater small-cell lung cancers t-cell-derived il-12 ts2-specific gene expression specific inter-cellular interactions inter-cellular interactions suggest tissue-specific resident populations anti-human 4-color dendritic granzyme b-secreting cytotoxic small-cell lung cancer advanced-stage lung cancers humoral immune responses b-cell differentiation pathway anti-tumor immune response fb-c3 exclusively originated pro-inflammatory cytokine genes rna-seq data
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