
NCBI . NLM . NIH . GOV {
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Title[redir]:
Revisiting the Role of LXRs in PUFA Metabolism and Phospholipid Homeostasis - PMC
Description:
Liver X receptors (LXRs) play a pivotal role in fatty acid (FA) metabolism. So far, the lipogenic consequences of in vivo LXR activation, as characterized by a major hepatic steatosis, has constituted a limitation to the clinical development of ...
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Keywords {🔍}
doi, lxr, pubmed, google, scholar, lxrs, liver, lpcat, pmc, metabolism, pufas, article, free, fatty, acid, macrophages, pufa, phospholipid, activation, pltp, lipid, synthesis, fads, gene, mice, role, protein, cell, transfer, regulation, expression, srebpc, biol, secretion, cells, activity, receptor, vldl, membrane, hepatic, agonists, acids, phospholipids, control, lipogenesis, inflammation, cholesterol, acylcoa, acsl, genes,
Topics {✒️}
carbohydrate-response element-binding protein arachidonate-preferring acyl-coa synthetase arachidonate-preferring acyl-coa synthase acyl-coa synthase activity pmc beta search inhibit tlr/myd88 signaling db/db diabetic mouse srebp1 chip-seq peaks phospholipid-transfer protein deficiency ob/ob female mice polyunsaturated fatty acids antagonizing ligand-dependent activation long-chain fas proteins abca1-dependent cholesterol depletion acyl-coa synthase large-sized vldl particles steroyl-coa desaturase omega-3 fatty acids long-chain n-3 pufas fatty acyl chain trans-repression mechanism involving ligand-dependent sumoylation [46] pro-inflammatory tlr4 signaling monounsaturated fatty acids lxr-lpcat3 pathway protects increases lysophosphatidylcholine acyltransferase phospholipid transfer protein lpcat3-deficient mice display pufa-derived lipid mediators transcription start site desmosterol inhibits fads1 fatty acid synthase desaturase gene expression publisher site pdf acetyl-coa carboxylase adipose tissue inflammation anti-inflammatory n-3 pufas lxralpha-srebp-1c free cholesterol [38] receptor-mediated lipotoxicity long-chain n-3 long-chain n-6 promoter-specific roles ap-1 responsive genes license information pmcid mouse primary hepatocytes monounsaturated fatty acid basal expression levels anti-inflammatory activity concordant studies show
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