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We began analyzing https://www.nature.com/articles/nm0701_847, but it redirected us to https://www.nature.com/articles/nm0701_847. The analysis below is for the second page.

Title[redir]:
Apolipoprotein B secretion and atherosclerosis are decreased in mice with phospholipid-transfer protein deficiency | Nature Medicine
Description:
Increased secretion and levels of ApoB-containing lipoproteins (BLp) commonly occur in familial hyperlipidemia, obesity and diabetes. The plasma phospholipid-transfer protein (PLTP) is known to mediate transfer of phospholipids between BLp and HDL during their intravascular metabolism. To address a possible role of PLTP in dyslipidemia and atherogenesis, we bred mice deficient in the gene encoding PLTP (PLTP-deficient mice) using different hyperlipidemic mouse strains. In ApoB-transgenic and ApoE-deficient backgrounds, PLTP deficiency resulted in reduced production and levels of BLp and markedly decreased atherosclerosis. BLp secretion was diminished in hepatocytes from ApoB-transgenic PLTP-deficient mice, a defect that was corrected when PLTP was reintroduced in adenovirus. The studies reveal a major, unexpected role of PLTP in regulating the secretion of BLp and identify PLTP as a therapeutic target.

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Keywords {🔍}

article, google, scholar, cas, apolipoprotein, nature, protein, transfer, mice, secretion, access, lipid, clin, atherosclerosis, pltp, disease, invest, content, plasma, role, gene, cookies, tall, lipoproteins, pubmed, privacy, medicine, deficiency, jiang, levels, blp, york, science, cell, lipoprotein, phospholipid, biol, data, xiao, hyperlipidemia, human, metabolic, basis, inherited, cholesteryl, molecular, function, advertising, analysis, information,

Topics {✒️}

nature portfolio permissions reprints privacy policy advertising increased high-density lipoprotein nature 342 nature 496 nature social media plasma phospholipid-transfer protein phospholipid-transfer protein deficiency author information authors bactericidal/permeability-increasing protein development adenovirus-mediated gene delivery 131i-labeled plasma proteins author correspondence apob-transgenic pltp-deficient mice phospholipid transfer protein apolipoprotein e-deficient mouse personal data high density lipoproteins markedly decreased atherosclerosis chylomicron-sized lipid particles phospholipid transfer activity anna skold & xiao xiao data protection springerlink instant access permissions atherosclerotic cardiovascular disease lipid-transfer function cholesterol transport protein gene-targeted mice article jiang privacy bred mice deficient stable isotope technique gene encoding pltp coronary heart disease insulin-dependent diabetes pltp-deficient mice explore content subscription content hyperlipidemic mouse strains apoe-deficient backgrounds mice lacking apolipoprotein european economic area pltp deficiency resulted institutional subscriptions read frame stop codon

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