
DOI . ORG {
}
Title[redir]:
Lpcat3-dependent production of arachidonoyl phospholipids is a key determinant of triglyceride secretion | eLife
Description:
Living cells are surrounded by a membrane that forms a barrier between the cell and its external environment. This membrane is largely made up of a variety of molecules known as lipids. The particular lipid molecules found in a cell membrane strongly influence its mobility, flexibility and other physical properties. The liver and intestine can package lipids gained from the diet into molecules called lipoproteins, which are released into the bloodstream for use by the body. An enzyme known as Lpcat3 is found in high levels in the liver and intestine and it appears to be involved in the production of lipoproteins. Altering the amount of Lpcat3 in cells can change the types of lipids found in the cell membranes, connected to the production of lipoproteins. Rong et al. studied newborn mice that were missing the Lpcat3 protein in either the liver or intestine. Mice lacking Lpcat3 in the intestine had higher levels of lipids inside their intestine cells and grew more slowly than normal mice. Mice lacking Lpcat3 in the liver also accumulated lipids in their cells and their bloodstream had lower levels of lipids that contain a molecule called arachidonic acid than normal mice. Further experiments showed that the loss of Lpcat3 reduces the ability of lipids to move within the cell membrane. The experiments show that Lpcat3 plays a key role in attaching arachidonic acid to membrane lipids to promote the release of lipoproteins into the bloodstream. Rong et al.
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Keywords {π}
lpcat, mice, figure, lipid, liver, membrane, plasma, vldl, levels, llpcat, expression, google, scholar, data, asset, lipoprotein, species, lpcatflfl, composition, analysis, httpsdoiorgelife, diet, apob, secretion, membranes, download, reduced, open, knockout, lipids, hepatic, cell, cells, livers, production, pls, lipoproteins, observed, supplement, article, university, united, states, particles, western, journal, research, arachidonoyl, role, loss,
Topics {βοΈ}
endogenous 1-o-alk-1'-enyl-2-acyl-sn-glycerol phosphatidylethanolamine n-methyltransferase-derived phosphatidylcholine /conditional-readyβ gene-targeting vector esi-ms/ms revealed imidazole-buffered osmium tetroxide lpcat3-deficient mouse models lpcat3fl/fl albumin-cre intercrosses esi-ms/ms analysis lpcat-dependent remodeling process polyunsaturated fatty acyl-coas yellow/orange pseudocolor signal cell death-inducing dff45 tissue-specific knockout mice 2-ditetradecanoyl-sn-glycero-3-phosphoethanolamine fasting l-lpcat3 ko high-percentage male chimeras 1-0-heptadecanoyl-sn-glycero-3-phosphocholine 2-dieicosanoyl-sn-glycero-3-phosphocholine designated βl-lpcat3 ko i-lpcat3 ko mice tissue-selective knockout mice conditional-ready knockout allele genome-wide association study l-lpcat3 mice gavaged l-lpcat3 ko mice carbon-coated copper grids vqad-cmv cre/egfp i-lpcat3 ko pups wako l-type tg cell-based assays suggest albumin-cre transgenic mice male lpcat3fl/fl mice generated lpcat3-deficient mice 12-hr light/dark cycle villin-cre transgenic mice imidazole-stained liver sections acute shrna-mediated knockdown l-lpcat3 ko livers altered tg content 40 mg/kg/day gw3956 cre-expressing adenoviral vector bligh-dyer lipid extraction reduced tg-rich apob intestinal apob-deficient mice lpcat3-deficient livers suggests steady-state laurdan fluorescence tg-rich vldl assembly xin rongbo wangmerlow polyunsaturated fatty acids lpcat3fl/fl albumin-cre
Questions {β}
- Vance JEVance DE (1988) Does rat liver Golgi have the capacity to synthesize phospholipids for lipoprotein secretion?
Schema {πΊοΈ}
ScholarlyArticle:
context:https://schema.org
mainEntityOfPage:
type:WebPage
id:https://elifesciences.org/articles/06557
headline:Lpcat3-dependent production of arachidonoyl phospholipids is a key determinant of triglyceride secretion
datePublished:2015-03-25
author:
type:Person
name:Xin Rong
type:Person
name:Bo Wang
type:Person
name:Merlow M Dunham
type:Person
name:Per Niklas Hedde
type:Person
name:Jinny S Wong
type:Person
name:Enrico Gratton
type:Person
name:Stephen G Young
type:Person
name:David A Ford
type:Person
name:Peter Tontonoz
publisher:
type:Organization
name:eLife Sciences Publications, Ltd
logo:
type:ImageObject
url:https://elifesciences.org/assets/patterns/img/patterns/organisms/[email protected]
keywords:
phospholipid
lipoprotein
nuclear receptor
about:
Cell Biology
description:The enzyme Lpcat3 plays a unique role in the incorporation of arachidonic acid into membranes, which is required for the production of lipoproteins.
isPartOf:
type:Periodical
name:eLife
issn:2050-084X
WebPage:
id:https://elifesciences.org/articles/06557
Person:
name:Xin Rong
name:Bo Wang
name:Merlow M Dunham
name:Per Niklas Hedde
name:Jinny S Wong
name:Enrico Gratton
name:Stephen G Young
name:David A Ford
name:Peter Tontonoz
Organization:
name:eLife Sciences Publications, Ltd
logo:
type:ImageObject
url:https://elifesciences.org/assets/patterns/img/patterns/organisms/[email protected]
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url:https://elifesciences.org/assets/patterns/img/patterns/organisms/[email protected]
Periodical:
name:eLife
issn:2050-084X
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