
NCBI . NLM . NIH . GOV {
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Title[redir]:
Genetically Induced Adult Oligodendrocyte Cell Death Is Associated with Poor Myelin Clearance, Reduced Remyelination, and Axonal Damage - PMC
Description:
Loss of oligodendrocytes is a feature of many demyelinating diseases including multiple sclerosis. Here, we have established and characterized a novel model of genetically induced adult oligodendrocyte death. Specific primary loss of adult ...
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Keywords {🔍}
myelin, doi, mice, fig, experimental, disease, google, scholar, pubmed, adult, cells, cell, remyelination, stage, death, end, time, matter, sections, tissue, axonal, affected, white, oligodendrocyte, model, data, loss, debris, axons, animals, observed, immune, mouse, analyzed, staining, damage, development, clinical, brain, spinal, induced, regions, pmc, vacuolation, areas, cns, olg, cerebellar, cord, induction,
Topics {✒️}
mouse-anti-amyloid precursor protein primary antibodies [goat-anti-sox10 vehicle-injected double-transgenic animals plp–creert2/cre-dependent r26 tam-treated single-transgenic animals olig2/idu/dapi-stained sections ng2/yfp/dapi-stained sections tam-treated double-transgenic animals mouse lines plp–creert2 birdcage transmit–receive coil optimized tam-inducible version normal light/dark cycle exemplary double-positive cell multi-spin echo sequence pmc beta search inducible plp–creert2 line fluorescence-coupled secondary antibodies rag-1 wild-type background pmc copyright notice cre-dependent r26r-eyfp double-transgenic animals treated polysine-coated glass slides mouse-anti-nonphosphorylated neurofilaments ectopic t-cell specificity sunflower oil/ethanol mixture heat-mediated antigen retrieval general axonal/neuronal impairment subsequent cell-intrinsic expression disrupting myelin–axon interactions myelin debris-filled vacuoles oligodendrocyte precursor differentiation immune-deficient mouse background oligodendrocyte precursor proliferation publisher site pdf experimental autoimmune encephalomyelitis adult oligodendrocyte death intact blood–brain barrier axon area/fiber area mbp-stained paraffin sections induced cell death olg cell death adult olg death proliferative opcs shows evans blue dye single myelin lamellae normal-appearing myelin spinal cord white genetically induced loss cerebellar white matter double-transgenic offspring
Questions {❓}
- Multiple sclerosis: an immune or neurodegenerative disorder?
- Why is Wallerian degeneration in the CNS so slow?
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