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Title[redir]:
To NET or not to NET:current opinions and state of the science regarding the formation of neutrophil extracellular traps - PMC
Description:
Since the discovery and definition of neutrophil extracellular traps (NETs) 14 years ago, numerous characteristics and physiological functions of NETs have been uncovered. Nowadays, the field continues to expand and novel mechanisms that orchestrate ...
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Keywords {🔍}
doi, pubmed, google, scholar, neutrophil, extracellular, pmc, article, formation, free, net, nets, traps, cell, dna, neutrophils, immunol, death, trap, release, human, pad, nat, blood, sci, med, pathways, mitochondrial, netosis, lupus, research, chromatin, nuclear, activity, front, role, dnase, biol, disease, inflammation, arthritis, conditions, tissue, defense, quantification, paper, authors, wang, fimmu, forms,
Topics {✒️}
ripk1/ripk3/mlkl-dependent pathway crystal-induced net formation monosodium urate crystals protein–dna interactions constrain rip3/mlkl-independent extrusion fine-tune therapeutic approaches nanoparticles size-dependently initiate pmc beta search enzyme-linked immunosorbent assay serum-free culture conditions papillon-lefevre syndrome ros-dependent net formation chromosome-sized dna molecules nadph oxidase inhibits atg5-knockout mouse neutrophils acute gouty arthritis neutrophil extracellular trap myeloid dendritic cells organelle fusion events trex1-deficient mouse model autoimmune small-vessel vasculitis phagocytosis-independent antimicrobial activity pma-induced net formation neutrophil extracellular traps extracellular trap formation extracellular trap release net formation requires oxidative burst-dependent netosis canonical inflammasome signalling neutrophil serine proteases ethical standards conflict tumor-bearing animals impairs wound healing extracellular neutrophil proteases called late-autophagy inhibitors publisher site pdf papillon–lefèvre syndrome monocyte extracellular traps extracellular dna derived ros-dependent formation dependent mechanism involving extracellular dna traps social amoebae trap limiting netosis-driven inflammation license information pmcid feline leukemia virus neutrophils promote alzheimer autophagy-related signaling human immunodeficiency virus-1 potential tissue-damaging properties
Questions {❓}
- Are NETs primarily formed from nuclear or mitochondrial DNA, or both?
- Extracellular DNA: the tip of root defenses?
- How can we unambiguously distinguish NETs from the remnants of other forms of cell death?
- How neutrophils die or survive along NET release and is “NETosis” = necroptosis?
- Is there a connection between NET formation, neutrophil aggregation and/or neutrophil swarming?
- Is there a link between autophagy, necroptosis, pyroptosis and NET formation?
- Killing by neutrophil extracellular traps: fact or folklore?
- NETosis: how vital is it?
- Neutrophil extracellular traps: is immunity the second function of chromatin?
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