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We began analyzing https://link.springer.com/article/10.1007/BF00284071, but it redirected us to https://link.springer.com/article/10.1007/BF00284071. The analysis below is for the second page.

Title[redir]:
Chromosome-sized DNA molecules from Drosophila | Chromosoma
Description:
Measurements of viscoelastic retardation times of detergent-Pronase lysates of Drosophila cells demonstrated the presence of large numbers of DNA molecules of a size commensurate with that of the chromosomes. The values estimated from the retardation times for the molecular weights of the largest molecules ranged from about 20×109 to 80×109 daltons depending on the species of Drosophila. The molecular weights of the DNA molecules were independent of the metaphase shapes (i.e., metacentric or submetacentric), but were proportional to the DNA contents of the chromosomes in the case of translocations or deletions. It was concluded, therefore, that the DNA molecules must run the length of the chromosome and cannot be discontinuous at the centromere. When compared with the values of the DNA contents of Drosophila chromosomes determined by other methods, the results were consistent with the model of one, or possibly two, DNA molecules per chromosome; the simplest conclusion, that there is only one DNA molecule per chromosome (for simple chromosomes), rests on a long extrapolation of an empirical relation between retardation time and molecular weight, but is also favored by indirect evidence. Further possibilities which could not be excluded were that the large DNA molecules contained Pronase-resistant, non-DNA links, or that a fraction of smaller DNA molecules might also have been present in the chromosomes. Chromosome-sized DNA molecules were obtained almost quantitatively from unsynchronized cultured cells, suggesting that the size of the chromosomal DNA is conserved throughout much of the cell cycle. The molecules were stable for periods of up to several days at 50° C in solutions containing detergent, Pronase, and EDTA.

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Keywords {🔍}

dna, google, scholar, biol, drosophila, chromosomes, molec, molecules, article, molecular, chromosome, proc, content, zimm, nat, acad, sci, wash, melanogaster, chromosoma, cell, access, coli, acid, press, sedimentation, privacy, cookies, kavenoff, retardation, cells, deoxyribonucleic, structure, publish, research, search, measurements, times, size, weight, chromosomal, organization, open, escherichia, york, autoradiography, replication, viscosity, data, information,

Topics {✒️}

chromosome-sized dna molecules month download article/chapter random double-strand breaks single-stranded t7 dna indirect evidence polytene chromosome dna related subjects nucleic acid research privacy choices/manage cookies cell cycle full article pdf article chromosoma aims drosophila melanogaster evidence dna-binding protein single dna molecules hela cell dna bacterial chromosome largest molecules ranged smaller dna molecules molecular weight european economic area double-stranded model sodium dodecyl sulfate gel-forming properties tritium-labeled thymidine vicia faba chromosomes dna-cellulose chromatography interspersed spacer dna bacterial dna molecules conditions privacy policy chromosome structure methods simple salt concentration t5 bacteriophage mutants individual metaphase chromosomes dna-binding proteins unsynchronized cultured cells chinese hamster cells detergent-pronase lysates check access instant access chromosomal dna fibers accepting optional cookies article kavenoff interphase nuclei compared nucleotide sequence diversity enzyme digestion studies measuring retardation times drosophila chromosomes determined drosophila cells demonstrated

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