
NCBI . NLM . NIH . GOV {
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Title[redir]:
Metabolomic Profiling of Bile Acids in an Experimental Model of Prodromal Parkinson’s Disease - PMC
Description:
For people with Parkinson’s disease (PD), considered the most common neurodegenerative disease behind Alzheimer’s disease, accurate diagnosis is dependent on many factors; however, misdiagnosis is extremely common in the prodromal phases of the ...
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Keywords {🔍}
doi, bile, acids, acid, google, scholar, pubmed, disease, mice, pmc, article, model, prodromal, free, hmdb, parkinsons, αsyn, serum, brain, regression, data, tudca, logistic, gut, significantly, fold, figure, alzheimers, concentrations, study, liver, fibrils, previously, reported, group, mouse, udca, neuroprotective, nlm, metabolites, work, ursodeoxycholic, pff, humonomers, research, health, potential, injected, pffs, usa,
Topics {✒️}
wilcoxon–mann–whitney u-test wilcoxon–mann–whitney test α-syn monomers-injected mice α-syn fibrils-injected mice pmc beta search human α-syn monomers purified recombinant α-syn express human α-syn include ω-murichoclic acid human α-syn fibrils olfactory bulb alpha-synucleinopathy targeting bile-acid signalling α-syn fibrils leads disease-modifying clinical trials bonferroni-corrected p-values transmission electron microscopy k-fold cross-validation recombinant α-syn long-term neurodegenerative disease logistic regression model—summary potential disease-modifying treatment membrane-bound receptors license information pmcid age-matched controls injected [google scholar] 43 electron microscopy science publisher site pdf predictive model capable fulminant hepatic failure microbiome-gut-brain axis diagnostic algorithm capable α-syn fibrils biocrates metidq software van der merwe supplementary materials included reduce neuronal loss alpha-muricholic acid α-synucleinopathy shows inducing α-synucleinopathy α-synucleinopathy triggered reduced long term human alpha-synuclein α-syn aggregates modulating neuronal proliferation misfolded α-synuclein criteria including bradykinesia promote fat digestion developing α-synucleinopathy financially support research omega-murichoclic acid
Questions {❓}
- So, is the formation of the α-syn aggregates in the brain directly affecting the PFF mouse gut bacteria and the formation of secondary bile acids deemed neuroprotective?
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Analytics and Tracking {📊}
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