NCBI . NLM . NIH . GOV {
}
We began analyzing https://pmc.ncbi.nlm.nih.gov/articles/PMC5528349/, but it redirected us to https://pmc.ncbi.nlm.nih.gov/articles/PMC5528349/. The analysis below is for the second page.
Title[redir]:
Trials with āepigeneticā drugs: An update - PMC
Description:
Epigenetic inactivation of pivotal genes involved in correct cell growth is a hallmark of human pathologies, in particular cancer. These epigenetic mechanisms, including crosstalk between DNA methylation, histone modifications and nonācoding RNAs, ...
Title[redir]:
Trials with āepigeneticā drugs: An update - PMC
Description:
Epigenetic inactivation of pivotal genes involved in correct cell growth is a hallmark of human pathologies, in particular cancer. These epigenetic mechanisms, including crosstalk between DNA methylation, histone modifications and nonācoding RNAs, ...
Matching Content Categories {š}
- Education
- Health & Fitness
- Science
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Custom-built
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š Phenomenal Traffic: 5M - 10M visitors per month
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Keywords {š}
phase, nct, pubmed, google, scholar, doi, cancer, completed, histone, clinical, pmc, cell, article, dna, free, vorinostat, inhibitor, leukemia, deacetylase, terminated, study, journal, decitabine, azacitidine, cells, trials, lymphoma, inhibitors, human, epigenetic, methylation, tumor, treatment, activity, research, solid, romidepsin, curcumin, acid, mds, resveratrol, therapy, tumors, patients, dnmt, diseases, expression, drugs, disease, lung,
Topics {āļø}
phase 1 decitabineĀ +Ā filgrastimĀ +Ā busulfanĀ +Ā cyclophosphamideĀ +Ā cyclosporineĀ +Ā methotrexateĀ +Ā methylprednisolonĀ +Ā tacrolimus p300/creb-binding protein-specific inhibitor retinoic acid receptor/retinoid phase 2 decitabineĀ +Ā filgrastimĀ +Ā cyclosporine pmc beta search domain-selective small-molecule inhibitor estrogen receptor-alpha dermatophagoides farinea-induced interleukin-5 dicyclo-hexyl-amine salt alpha-induced oxidative stress n-phthalyl-l-tryptophan n-hydroxypyrim idine-5-carboxamide acid sphingomyelinase-dependent generation flavinādependent monoamine oxidase de la cruz-hernandez fas -deficient mrl/lpr 3ādihydroā2hāisoindolā2āyl myelopathy/tropical spastic paraparesis neoadjuvant doxorubicin cyclophosphamide hypomethylating agent-based therapy shortāchain fatty acids fas ligand-induced apoptosis peripheral t-cell lymphoma ļæ½generation polarāplanar compound dynamic multi-compartmental model hydroxamic acidābased hdaci ļæ½smallācell lung carcinoma node-positive breast cancer hdac inhibitor-induced apoptosis gene-targeted nucleic acids phase 1 romidepsinĀ +Ā rituximabĀ +Ā fludarabine diseaseāfree survival suberoylanilide hydroxamic acid histone-deacetylase inhibitor givinostat dna doubleāstrand repair poor-risk myelodysplastic syndromes nad+ādependent protein deacetylases drugābinding pocket display human cml-bc cells death receptor pathway aspirināexacerbated respiratory disease develop tailorāmade therapies anacardic acid-inspired benzamides preclinical anti-myeloma activity phases azacitidineĀ +Ā vpaĀ +Ā atra cutaneous t-cell lymphoma s-adenosyl homocysteine hydrolase phase 2 azacitidineĀ +Ā vpaĀ +Ā atra phase 3 azacitidineĀ +Ā vpaĀ +Ā atra cellular [nad+]/[nadh] ratio
Questions {ā}
- A therapeutic role for sirtuins in diseases of aging?
- Emerging anticancer therapeutic targets and the cardiovascular system: is there cause for concern?
- Histone methyltransferases: a new class of therapeutic targets in cancer treatment?
- How does SIRT1 affect metabolism, senescence and cancer?
- SIRT1, is it a tumor promoter or tumor suppressor?
- Will histone deacetylase inhibitors require combination with other agents to fulfil their therapeutic potential?
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- How much cash flow does https://doi.org/10.1158/0008-5472.CAN-08-3669 have monthly?
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- Income figures for https://scholar.google.com/scholar_lookup?journal=Clinical%20Cancer%20Research&title=Histone%20deacetylase%20inhibitor%20panobinostat%20induces%20clinical%20responses%20with%20associated%20alterations%20in%20gene%20expression%20profiles%20in%20cutaneous%20T-cell%20lymphoma&author=L.%20Ellis&author=Y.%20Pan&author=G.K.%20Smyth&author=D.J.%20George&author=C.%20McCormack&volume=14&publication_year=2008&pages=4500-4510&pmid=18628465&doi=10.1158/1078-0432.CCR-07-4262&
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- https://doi.org/10.1158/1078-0432.CCR-07-1320's financial summary
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- What's the profit of https://doi.org/10.2174/156802608784911581?
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- What's the income generated by https://doi.org/10.1016/j.intimp.2011.10.010 each month?
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- How profitable is https://doi.org/10.1006/excr.1998.4027?
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- What's the financial outcome of https://scholar.google.com/scholar_lookup?journal=Carcinogenesis&title=(-)-Epigallocatechin-3-gallate%20reactivates%20silenced%20tumor%20suppressor%20genes,%20Cip1/p21%20and%20p16INK4a,%20by%20reducing%20DNA%20methylation%20and%20increasing%20histones%20acetylation%20in%20human%20skin%20cancer%20cells&author=V.%20Nandakumar&author=M.%20Vaid&author=S.K.%20Katiyar&volume=32&publication_year=2011&pages=537-544&pmid=21209038&doi=10.1093/carcin/bgq285&?
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- Revenue of https://doi.org/10.1002/cncr.25584
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- https://doi.org/10.1158/1535-7163.MCT-09-0689 income
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- Profit of https://doi.org/10.1097/JTO.0b013e3181ec1713
- Earnings of https://scholar.google.com/scholar_lookup?journal=Journal%20of%20Thoracic%20Oncology&title=Phase%20II%20study%20of%20the%20histone%20deacetylase%20inhibitor%20romidepsin%20in%20relapsed%20small%20cell%20lung%20cancer%20(Cancer%20and%20Leukemia%20Group%20B%2030304)&author=G.A.%20Otterson&author=L.%20Hodgson&author=H.%20Pang&author=E.E.%20Vokes&volume=5&publication_year=2010&pages=1644-1648&pmid=20871263&doi=10.1097/JTO.0b013e3181ec1713&
- How much money does https://scholar.google.com/scholar_lookup?journal=Acta%20Naturae&title=New%20approaches%20for%20cancer%20treatment:%20antitumor%20drugs%20based%20on%20gene-targeted%20nucleic%20acids&author=O.A.%20Patutina&author=N.L.%20Mironova&author=V.V.%20Vlassov&author=M.A.%20Zenkova&volume=1&publication_year=2009&pages=44-60&pmid=22649602& generate?
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- How much cash flow does https://scholar.google.com/scholar_lookup?journal=Cellular%20Signalling&title=DNA%20hypermethylation%20as%20a%20chemotherapy%20target&author=J.%20Ren&author=B.N.%20Singh&author=Q.%20Huang&author=Z.%20Li&author=Y.%20Gao&volume=23&publication_year=2011&pages=1082-1093&pmid=21345368&doi=10.1016/j.cellsig.2011.02.003& have monthly?
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- Financial intake of https://scholar.google.com/scholar_lookup?journal=Current%20Opinion%20in%20Cell%20Biology&title=Histone%20methylation%20versus%20histone%20acetylation:%20new%20insights%20into%20epigenetic%20regulation&author=J.C.%20Rice&author=C.D.%20Allis&volume=13&publication_year=2001&pages=263-273&pmid=11343896&doi=10.1016/s0955-0674(00)00208-8&
- Get to know https://doi.org/10.1080/10428190701817258's earnings
- What's https://scholar.google.com/scholar_lookup?journal=Leukemia%20&%20Lymphoma&title=Phase%20I%20trial%20of%20oral%20vorinostat%20(suberoylanilide%20hydroxamic%20acid,%20SAHA)%20in%20patients%20with%20advanced%20multiple%20myeloma&author=P.%20Richardson&author=C.%20Mitsiades&author=K.%20Colson&author=E.%20Reilly&author=L.%20McBride&volume=49&publication_year=2008&pages=502-507&pmid=18297527&doi=10.1080/10428190701817258&'s gross income?
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- https://scholar.google.com/scholar_lookup?journal=Proceedings%20of%20the%20National%20Academy%20of%20Sciences%20of%20the%20United%20States%20of%20America&title=A%20class%20of%20hybrid%20polar%20inducers%20of%20transformed%20cell%20differentiation%20inhibits%20histone%20deacetylases&author=V.M.%20Richon&author=S.%20Emiliani&author=E.%20Verdin&author=Y.%20Webb&author=R.%20Breslow&volume=95&publication_year=1998&pages=3003-3007&pmid=9501205&doi=10.1073/pnas.95.6.3003&'s financial summary
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- What's the revenue for https://scholar.google.com/scholar_lookup?journal=Journal%20of%20Mammary%20Gland%20Biology%20and%20Neoplasia&title=Breast%20cancer%20epigenetics:%20from%20DNA%20methylation%20to%20microRNAs&author=J.%20Veeck&author=M.%20Esteller&volume=15&publication_year=2010&pages=5-17&pmid=20101446&doi=10.1007/s10911-010-9165-1&?
- What is the monthly revenue of https://doi.org/10.1097/MPA.0b013e31821f677d?
- What's the financial outcome of https://scholar.google.com/scholar_lookup?journal=Pancreas&title=Impact%20of%20curcumin,%20raspberry%20extract,%20and%20neem%20leaf%20extract%20on%20rel%20protein-regulated%20cell%20death/radiosensitization%20in%20pancreatic%20cancer%20cells&author=J.%20Veeraraghavan&author=M.%20Natarajan&author=P.%20Lagisetty&author=V.%20Awasthi&author=T.S.%20Herman&volume=40&publication_year=2011&pages=1107-1119&pmid=21697760&doi=10.1097/MPA.0b013e31821f677d&?
- See how much https://doi.org/10.1016/j.bcp.2004.05.041 makes per month
- What are the earnings of https://scholar.google.com/scholar_lookup?journal=Biochemical%20Pharmacology&title=Epigenetic%20gene%20silencing%20in%20acute%20promyelocytic%20leukemia&author=R.%20Villa&author=F.%20De%20Santis&author=A.%20Gutierrez&author=S.%20Minucci&author=P.G.%20Pelicci&volume=68&publication_year=2004&pages=1247-1254&pmid=15313423&doi=10.1016/j.bcp.2004.05.041&?
- Check the income stats for https://doi.org/10.1093/jnci/90.21.1621
- Check the income stats for https://scholar.google.com/scholar_lookup?journal=Journal%20of%20the%20National%20Cancer%20Institute&title=Therapeutic%20targeting%20of%20transcription%20in%20acute%20promyelocytic%20leukemia%20by%20use%20of%20an%20inhibitor%20of%20histone%20deacetylase&author=R.P.%20Warrell&author=L.Z.%20He&author=V.%20Richon&author=E.%20Calleja&author=P.P.%20Pandolfi&volume=90&publication_year=1998&pages=1621-1625&pmid=9811311&doi=10.1093/jnci/90.21.1621&
- Income figures for https://doi.org/10.1016/s0065-2423(10)52006-7
- What's the monthly money flow for https://scholar.google.com/scholar_lookup?journal=Advances%20in%20Clinical%20Chemistry&title=Methylation%20of%20DNA%20in%20cancer&author=Y.%20Watanabe&author=M.%20Maekawa&volume=52&publication_year=2010&pages=145-167&pmid=21275343&doi=10.1016/s0065-2423(10)52006-7&?
- What's the financial gain of https://doi.org/10.1016/j.tibs.2007.09.008?
- What's the monthly income of https://scholar.google.com/scholar_lookup?journal=Trends%20in%20Biochemical%20Sciences&title=A%20therapeutic%20role%20for%20sirtuins%20in%20diseases%20of%20aging?&author=C.H.%20Westphal&author=M.A.%20Dipp&author=L.%20Guarente&volume=32&publication_year=2007&pages=555-560&pmid=17980602&doi=10.1016/j.tibs.2007.09.008&?
- What is the monthly revenue of https://doi.org/10.1007/s10637-008-9190-8?
- How much does https://scholar.google.com/scholar_lookup?journal=Investigational%20New%20Drugs&title=Phase%20II%20trial%20of%20romidepsin%20(NSC-630176)%20in%20previously%20treated%20colorectal%20cancer%20patients%20with%20advanced%20disease:%20a%20Southwest%20Oncology%20Group%20study%20(S0336)&author=R.P.%20Whitehead&author=C.%20Rankin&author=P.M.%20Hoff&author=P.J.%20Gold&author=K.G.%20Billingsley&volume=27&publication_year=2009&pages=469-475&pmid=18941712&doi=10.1007/s10637-008-9190-8& make?
- How much income does https://doi.org/10.1016/j.bbcan.2010.03.003 have?
- Revenue of https://scholar.google.com/scholar_lookup?journal=Biochimica%20et%20Biophysica%20Acta&title=Genome-wide%20hypomethylation%20in%20cancer%20may%20be%20a%20passive%20consequence%20of%20transformation&author=L.%20Wild&author=J.M.%20Flanagan&volume=1806&publication_year=2010&pages=50-57&pmid=20398739&doi=10.1016/j.bbcan.2010.03.003&
- Earnings of https://doi.org/10.1007/s10637-006-5938-1
- How much does https://scholar.google.com/scholar_lookup?journal=Investigational%20New%20Drugs&title=Phase%20II%20trial%20of%20DNA%20methyltransferase%201%20inhibition%20with%20the%20antisense%20oligonucleotide%20MG98%20in%20patients%20with%20metastatic%20renal%20carcinoma:%20a%20National%20Cancer%20Institute%20of%20Canada%20Clinical%20Trials%20Group%20investigational%20new%20drug%20study&author=E.%20Winquist&author=J.%20Knox&author=J.P.%20Ayoub&author=L.%20Wood&author=N.%20Wainman&volume=24&publication_year=2006&pages=159-167&pmid=16502349&doi=10.1007/s10637-006-5938-1& earn?
- How much profit does https://scholar.google.com/scholar_lookup?journal=Zhonghua%20Zhong%20Liu%20Za%20Zhi%20%5BChinese%20Journal%20of%20Oncology%5D&title=Reversal%20effect%20of%205-Aza-dc%20on%20cisplatin-resistance%20in%20human%20NSCLC%20cells%20in%C2%A0vitro&author=F.%20Wu&author=C.H.%20Hu&volume=33&publication_year=2011&pages=349-353&pmid=21875463& generate?
- Income figures for https://doi.org/10.2174/092986710793205372
- What's the total monthly financial gain of https://scholar.google.com/scholar_lookup?journal=Current%20Medicinal%20Chemistry&title=Molecular%20and%20enzymatic%20profiles%20of%20mammalian%20DNA%20methyltransferases:%20structures%20and%20targets%20for%20drugs&author=F.%20Xu&author=C.%20Mao&author=Y.%20Ding&author=C.%20Rui&author=L.%20Wu&volume=17&publication_year=2010&pages=4052-4071&pmid=20939822&doi=10.2174/092986710793205372&?
- How much profit is https://doi.org/10.1038/sj.onc.1210620 making per month?
- How much does https://scholar.google.com/scholar_lookup?journal=Oncogene&title=Histone%20deacetylase%20inhibitors:%20molecular%20mechanisms%20of%20action&author=W.S.%20Xu&author=R.B.%20Parmigiani&author=P.A.%20Marks&volume=26&publication_year=2007&pages=5541-5552&pmid=17694093&doi=10.1038/sj.onc.1210620& pull in?
- How much cash flow does https://doi.org/10.1210/me.2007-0079 have monthly?
- What's the monthly income of https://scholar.google.com/scholar_lookup?journal=Molecular%20Endocrinology&title=Sirtuin%20functions%20in%20health%20and%20disease&author=H.%20Yamamoto&author=K.%20Schoonjans&author=J.%20Auwerx&volume=21&publication_year=2007&pages=1745-1755&pmid=17456799&doi=10.1210/me.2007-0079&?
- Financial intake of https://doi.org/10.4161/cbt.2.5.469
- Revenue of https://scholar.google.com/scholar_lookup?journal=Cancer%20Biology%20&%20Therapy&title=Specific%20inhibition%20of%20DNMT1%20by%20antisense%20oligonucleotides%20induces%20re-expression%20of%20estrogen%20receptor-alpha%20(ER)%20in%20ER-negative%20human%20breast%20cancer%20cell%20lines&author=L.%20Yan&author=S.J.%20Nass&author=D.%20Smith&author=W.G.%20Nelson&author=J.G.%20Herman&volume=2&publication_year=2003&pages=552-556&pmid=14614325&doi=10.4161/cbt.2.5.469&
- How profitable is https://doi.org/10.4049/jimmunol.1103035?
- https://scholar.google.com/scholar_lookup?journal=Journal%20of%20Immunology&title=Decitabine%20and%20vorinostat%20cooperate%20to%20sensitize%20colon%20carcinoma%20cells%20to%20Fas%20ligand-induced%20apoptosis%20in%C2%A0vitro%20and%20tumor%20suppression%20in%C2%A0vivo&author=D.%20Yang&author=C.M.%20Torres&author=K.%20Bardhan&author=M.%20Zimmerman&author=T.L.%20McGaha&volume=188&publication_year=2012&pages=4441-4449&pmid=22461695&doi=10.4049/jimmunol.1103035&'s financial summary
- Monthly income for https://doi.org/10.1093/nar/gkh252
- What's https://scholar.google.com/scholar_lookup?journal=Nucleic%20Acids%20Research&title=The%20diverse%20superfamily%20of%20lysine%20acetyltransferases%20and%20their%20roles%20in%20leukemia%20and%20other%20diseases&author=X.J.%20Yang&volume=32&publication_year=2004&pages=959-976&pmid=14960713&doi=10.1093/nar/gkh252&'s gross income?
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- What are the earnings of https://scholar.google.com/scholar_lookup?journal=The%20Lancet%20Oncology&title=Mocetinostat%20for%20relapsed%20classical%20Hodgkin's%20lymphoma:%20an%20open-label,%20single-arm,%20phase%202%20trial&author=A.%20Younes&author=Y.%20Oki&author=R.G.%20Bociek&author=J.%20Kuruvilla&author=M.%20Fanale&volume=12&publication_year=2011&pages=1222-1228&pmid=22033282&doi=10.1016/S1470-2045(11)70265-0&?
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- What are the total earnings of https://scholar.google.com/scholar_lookup?journal=Cancer%20Biology%20&%20Therapy&title=Histone%20deacetylase%20inhibitor%20LBH589%20reactivates%20silenced%20estrogen%20receptor%20alpha%20(ER)%20gene%20expression%20without%20loss%20of%20DNA%20hypermethylation&author=Q.%20Zhou&author=P.%20Atadja&author=N.E.%20Davidson&volume=6&publication_year=2007&pages=64-69&pmid=17172825&doi=10.4161/cbt.6.1.3549&?
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