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  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Keywords
  7. Topics
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We began analyzing https://link.springer.com/article/10.1007/s11095-012-0700-1, but it redirected us to https://link.springer.com/article/10.1007/s11095-012-0700-1. The analysis below is for the second page.

Title[redir]:
Inclusion Complex of Novel Curcumin Analogue CDF and β-Cyclodextrin (1:2) and Its Enhanced In Vivo Anticancer Activity Against Pancreatic Cancer | Pharmaceutical Research
Description:
Purpose Several formulations have been proposed to improve the systemic delivery of novel cancer therapeutic compounds, including cyclodextrin derivatives. We aimed to synthesize and characterize of CDF-β-cyclodextrin inclusion complex (1:2) (CDFCD). Methods The compound was characterized by Fourier transform infrared, differential scanning calorimetry, powder X-ray diffraction studies, H1 & C13 NMR studies and scanning electron microscopic analysis. Its activity was tested against multiple cancer cell lines, and in vivo bioavailability was checked. Results CDF-β-cyclodextrin was found to lower IC50 value by half when tested against multiple cancer cell lines. It preferentially accumulated in the pancreas, where levels of CDF-β-cyclodextrin in mice were 10 times higher than in serum, following intravenous administration of an aqueous CDF-β-cyclodextrin preparation. Conclusions Novel curcumin analog CDF preferentially accumulates in the pancreas, leading to its potent anticancer activity against pancreatic cancer cells. Synthesis of such CDF-β-cyclodextrin self-assembly is an effective strategy to enhance its bioavailability and tissue distribution, warranting further evaluation for CDF delivery in clinical settings for treatment of human malignancies.

Matching Content Categories {📚}

  • Education
  • Health & Fitness
  • Science

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


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How Does Doi.org Make Money? {💸}

The income method remains a mystery to us.

Many websites are intended to earn money, but some serve to share ideas or build connections. Websites exist for all kinds of purposes. This might be one of them. Doi.org has a secret sauce for making money, but we can't detect it yet.

Keywords {🔍}

article, google, scholar, cas, pubmed, cancer, curcumin, inclusion, complex, cdf, activity, padhye, cells, research, res, esm, pancreatic, pharm, chem, betacyclodextrin, banerjee, cdfβcyclodextrin, studies, nanoparticles, characterization, tiff, privacy, cookies, content, anticancer, ahmad, sarkar, delivery, preparation, access, wang, publish, search, analogue, vivo, prasad, vyas, abeda, jamadar, subhash, nmr, analog, properties, drug, mol,

Topics {✒️}

anne catherine dumhe-klaire month download article/chapter cdf-β-cyclodextrin inclusion complex aqueous cdf-β-cyclodextrin preparation results cdf-β-cyclodextrin anticancer drug trans-dichloro insulin-loaded plga nanoparticles abeda jamadar drug-cyclodextrin inclusion complexes cdf-β-cyclodextrin related subjects pancreatic cancer cells author information authors full article pdf curcumin analogue cdf anti-tumor activity privacy choices/manage cookies curcumin analog curr drug metab anti-inflammatory activity ortega-vinuesa jl supramolecular nanoencapsulation vitro physico-chemical characterization curcumin-loaded lipid center mm colon cancer stem global cancer statistics check access instant access pancreatic cancer solid lipid nanoparticles pegylated nanoparticles based polysaccharide-coated nanoparticles prostate cancer cells cancer therapeutic compounds differential scanning calorimetry aqueous dmso solution cancer prev res ferrocene-cyclodextrin complexes medicinal pigment curcumin including cyclodextrin derivatives european economic area fourier transform infrared difluoro knoevenagel condensates polymeric nanocapsules stabilized b16-f10 melanoma rat colitis model antiproliferative activities superior phase solubility techniques dimensional similarity searching

Questions {❓}

  • Curcumin and cancer cells: how many ways can curry kill tumor cells selectively?

Schema {🗺️}

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         description:Several formulations have been proposed to improve the systemic delivery of novel cancer therapeutic compounds, including cyclodextrin derivatives. We aimed to synthesize and characterize of CDF-β-cyclodextrin inclusion complex (1:2) (CDFCD). The compound was characterized by Fourier transform infrared, differential scanning calorimetry, powder X-ray diffraction studies, H1 & C13 NMR studies and scanning electron microscopic analysis. Its activity was tested against multiple cancer cell lines, and in vivo bioavailability was checked. CDF-β-cyclodextrin was found to lower IC50 value by half when tested against multiple cancer cell lines. It preferentially accumulated in the pancreas, where levels of CDF-β-cyclodextrin in mice were 10 times higher than in serum, following intravenous administration of an aqueous CDF-β-cyclodextrin preparation. Novel curcumin analog CDF preferentially accumulates in the pancreas, leading to its potent anticancer activity against pancreatic cancer cells. Synthesis of such CDF-β-cyclodextrin self-assembly is an effective strategy to enhance its bioavailability and tissue distribution, warranting further evaluation for CDF delivery in clinical settings for treatment of human malignancies.
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      description:Several formulations have been proposed to improve the systemic delivery of novel cancer therapeutic compounds, including cyclodextrin derivatives. We aimed to synthesize and characterize of CDF-β-cyclodextrin inclusion complex (1:2) (CDFCD). The compound was characterized by Fourier transform infrared, differential scanning calorimetry, powder X-ray diffraction studies, H1 & C13 NMR studies and scanning electron microscopic analysis. Its activity was tested against multiple cancer cell lines, and in vivo bioavailability was checked. CDF-β-cyclodextrin was found to lower IC50 value by half when tested against multiple cancer cell lines. It preferentially accumulated in the pancreas, where levels of CDF-β-cyclodextrin in mice were 10 times higher than in serum, following intravenous administration of an aqueous CDF-β-cyclodextrin preparation. Novel curcumin analog CDF preferentially accumulates in the pancreas, leading to its potent anticancer activity against pancreatic cancer cells. Synthesis of such CDF-β-cyclodextrin self-assembly is an effective strategy to enhance its bioavailability and tissue distribution, warranting further evaluation for CDF delivery in clinical settings for treatment of human malignancies.
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      name:Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Pune, India
      name:Department of Pathology, Barbara Ann Karmanos Cancer Center Wayne State University School of Medicine, Detroit, USA
      name:Department of Pathology, Barbara Ann Karmanos Cancer Center Wayne State University School of Medicine, Detroit, USA
      name:Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Pune, India
      name:Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Pune, India
      name:Department of Chemistry, University of York, Heslington, York, UK
      name:Department of Chemistry, University of York, Heslington, York, UK
      name:ISTRA, Department of Chemistry, MCE Society’s Abeda Inamdar Senior College of Arts, Science and Commerce, Pune, India
      name:Department of Pathology, Barbara Ann Karmanos Cancer Center Wayne State University School of Medicine, Detroit, USA
      name:Department of Pathology, Barbara Ann Karmanos Cancer Center Wayne State University School of Medicine, Detroit, USA
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