
NCBI . NLM . NIH . GOV {
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Title[redir]:
Intratumoral heterogeneity as a source of discordance in breast cancer biomarker classification - PMC
Description:
Spatial heterogeneity in biomarker expression may impact breast cancer classification. The aims of this study were to estimate the frequency of spatial heterogeneity in biomarker expression within tumors, to identify technical and biological factors ...
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Keywords {🔍}
cases, heterogeneity, cores, status, doi, breast, cancer, biomarker, tumor, discordant, receptor, study, clinical, intratumoral, pubmed, google, scholar, expression, discordance, agreement, automated, core, manually, analysis, case, tma, pmc, estrogen, positive, frequency, record, tmas, confirmed, studies, negative, article, progesterone, staining, central, impact, tissue, human, manual, free, invasive, helped, clin, identify, consortium, caselevel,
Topics {✒️}
1309/wbu9-22qn-c3na-2q12 pmc beta search multi-ethnic cohort study false-positive automated scores paraffin-embedded tumor blocks publisher site pdf case-level positivity status tumor cellularity-weighted approach case-level her2 status community-based clinical study human breast tumours biomarker-negative invasive carcinoma guiding targeted treatment primary breast cancer hormone receptor-negative tumors human research ethics her2-negative invasive tumor guide manual review define biomarker status breast cancer subtypes discordant biomarker-positive cases breast cancer subtyping methods study population license information pmcid intervening primary chemotherapy natl cancer inst representing community-based invasive breast cancer breast cancer classification population-based setting breast cancer research primary breast carcinoma define case status breast cancer treated breast cancer surgery early breast cancer breast cancer survivors breast cancer care variable expression levels paraffin-embedded tissues manually confirmed heterogeneity endocr relat cancer breast cancer heterogeneity oestrogen receptor expression small discordant regions central laboratory testing translational pathology laboratory discordant er-positive cases progesterone-receptor status united states government
Questions {❓}
- Breast cancer receptor status: do results from a centralized pathology laboratory agree with SEER registry reports?
- Does breast tumor heterogeneity necessitate further immunohistochemical staining on surgical specimens?
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- dns2-ncbi.ncbi.nlm.nih.gov
- lhcns1.nlm.nih.gov
- lhcns2.nlm.nih.gov
CDN Services {📦}
- Ncbi