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Keywords {🔍}

cases, heterogeneity, cores, cancer, breast, status, biomarker, tumor, article, pubmed, discordant, study, intratumoral, receptor, clinical, google, scholar, expression, discordance, automated, agreement, manually, core, central, analysis, cas, tma, frequency, estrogen, record, tmas, case, confirmed, studies, carolina, staining, positive, data, research, impact, progesterone, manual, manuscript, tissue, invasive, chapel, hill, usa, negative, clin,

Topics {✒️}

springer nature author information authors additional file 1 tissue microarray cores sections state privacy rights discussion background heterogeneity estrogen receptor results 1309/pj7h-a52v-m3xb-v94y conclusions rights false-positive automated scores nature progesterone-receptor status methods study population multi-ethnic cohort study nuclear v9 algorithm membrane v9 algorithm author correspondence original author estrogen receptor heterogeneity translational pathology laboratory discordant estrogen receptor background hormone receptor-negative tumors smaller tumor size automated methods central tma results paraffin-embedded tumor blocks automated algorithm privacy choices/manage cookies participating pathology laboratories er estrogen receptor digital algorithms authors scientific editing content case-level her2 status tumor cellularity-weighted approach case-level positivity status progesterone receptor oestrogen receptor expression bmc community-based clinical study information human research ethics biomarker-negative invasive carcinoma her2-negative invasive tumor progesterone receptors reconsidered human breast tumours

Questions {❓}

• Breast cancer receptor status: do results from a centralized pathology laboratory agree with SEER registry reports?
• Does breast tumor heterogeneity necessitate further immunohistochemical staining on surgical specimens?

Schema {🗺️}

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         Estrogen receptor
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         Intratumoral heterogeneity
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         Oncology
         Surgical Oncology
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               type:PostalAddress
            type:Organization
            name:University of North Carolina at Chapel Hill
            address:
               name:Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, USA
               type:PostalAddress
            type:Organization
      name:Melissa A. Troester
      affiliation:
            name:Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
            address:
               name:Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, USA
               type:PostalAddress
            type:Organization
            name:University of North Carolina at Chapel Hill
            address:
               name:Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, USA
      name:Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, USA
      name:Department of Pathology, Brigham & Women’s Hospital, Boston, USA
      name:Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, USA
      name:Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, USA
      name:Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, USA
      name:Department of Pathology, Roswell Park Cancer Institute, Buffalo, USA
      name:Department of Pathology, Roswell Park Cancer Institute, Buffalo, USA
      name:Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, USA
      name:Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, USA
      name:Division of Cancer Prevention, National Cancer Institute, Bethesda, USA
      name:Slone Epidemiology Center, Boston University, Boston, USA
      name:Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, USA
      name:Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, USA
      name:Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, USA
      name:Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, USA
      name:Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, USA

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