
NCBI . NLM . NIH . GOV {
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Title[redir]:
Clearance Deficiency and Cell Death Pathways: A Model for the Pathogenesis of SLE - PMC
Description:
Alterations of cell death pathways, including apoptosis and the neutrophil specific kind of death called NETosis, can represent a potential source of autoantigens. Defects in the clearance of apoptotic cells may be responsible for the initiation of ...
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Keywords {🔍}
sle, google, scholar, pubmed, doi, cells, lupus, apoptotic, patients, cell, clearance, systemic, pmc, article, free, erythematosus, nets, antibodies, death, autoantibodies, neutrophils, immunol, deficiency, autoantigens, disease, ifnα, crp, activity, apoptosis, immune, blood, macrophages, netosis, dnase, neutrophil, necrotic, chromatin, arthritis, impaired, complement, rheum, inflammation, proteins, dying, autoimmunity, production, human, extracellular, phagocytes, autoimmune,
Topics {✒️}
anti-sjögren’s-syndrome-related antigen song-chou hseih c-ly tyrosine kinase c-mer dna/anti-dna/ll37 complexes circulate monomeric c-reactive protein interferon-alpha mediates suppression pmc beta search phagocytose ig-coated beads pinto-da-silva lh crp/anti-crp antibodies assembly power – cell death induced foe – netting neutrophils immobilize opsonizing anti-beta2-glycoprotein dnase i-dependent degradation anti-neutrophil cytoplasmic antibody fc-receptor-mediated engulfment anti-neutrophil cytoplasmic antibodies ifn-α induced genes sle produce ifn-α apoptotic human t-cells surface code – biophysical signals cell-dependent immune response anti-ro/anti-ssa necrotic cell-derived chromatin subsequent anti-inflammatory response c-reactive protein mfg-e8-deficient mice anti-opsonin antibodies leads anti-ro/ssa antibodies anti-serum amyloid component chronic polyarthritis caused sphingosine-1-phosphate continually induces local stimulate macrophage chemotaxis double-stranded dna double stranded dna reported interferon-α activity receptor 9-dependent activation foster ifn-α production autoantibodies ifn-α signature normal opsonin-mediated clearance autophagy-related genes proinflammatory cytokines il-17a autophagy-related signaling reactive oxygen species anti-dnase antibodies compared significantly lower expression license information pmcid specific morphological features albumin-coated beads
Questions {❓}
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