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Title[redir]:
Immunosuppressive effects of apoptotic cells | Nature
Description:
Apoptotic cell death is important in the development and homeostasis of multicellular organisms1 and is a highly controlled means of eliminating dangerous, damaged or unnecessary cells without causing an inflammatory response or tissue damage1,2. We now show that the presence of apoptotic cells during monocyte activation increases their secretion of the anti-inflammatory and immunoregulatory cytokine interleukin 10 (IL-10) and decreases secretion of the proinflammatory cytokines tumour necrosis factor-α (TNF-α), IL-1 and IL-12. This may inhibit inflammation and contribute to impaired cell-mediated immunity in conditions associated with increased apoptosis, such as viral infections, pregnancy, cancer and exposure to radiation.
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nature, google, scholar, access, article, cookies, content, privacy, apoptotic, cells, research, data, scientific, cell, advertising, information, journal, subscribe, voll, herrmann, roth, death, institution, buy, immunol, permissions, optional, media, personal, parties, policy, journals, log, correspondence, november, immunosuppressive, effects, reinhard, martin, edith, christian, stach, joachim, kalden, irute, girkontaite, cite, development, inflammatory, tissue,
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nature portfolio permissions reprints connective tissue research privacy policy subscribe nature advertising nature 390 nature social media impaired cell-mediated immunity development triple-negative breast cancer personal data data protection springerlink instant access permissions membrane mechanical signatures apoptotic cells reinhard privacy explore content subscription content european economic area highly controlled means monocyte activation increases institutional subscriptions read ischaemic retinopathy kevin accepting optional cookies journals search log internal medicine iii apoptotic cells manage preferences anti-inflammatory m2 content christian stach & joachim access journal publish increased apoptosis article purchase tnf-α issue learn article cite optional cookies article voll choices conditions germany reinhard unnecessary cells essential cookies cookies skip cell 76
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