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Title[redir]:
Histone H3F3A and HIST1H3B K27M mutations define two subgroups of diffuse intrinsic pontine gliomas with different prognosis and phenotypes - PMC
Description:
Diffuse intrinsic pontine glioma (DIPG) is the most severe paediatric solid tumour, with no significant therapeutic progress made in the past 50 years. Recent studies suggest that diffuse midline glioma, H3-K27M mutant, may comprise more than one ...
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Keywords {🔍}
doi, dipg, tumours, hkm, genes, pubmed, google, scholar, fig, tumour, gene, samples, survival, histone, mutation, cells, mutations, expression, test, analysis, pvalue, patients, pdf, data, observed, pmc, subgroups, mutated, enhancement, hmutated, article, panel, cancer, contrast, loss, free, suppl, identified, mri, supplementary, material, found, clinical, alterations, cell, staining, diagnosis, distinct, acvr, molecular,
Topics {✒️}
pro-angiogenic/hypoxic signature supported edema/cellular invasion mri-phenotypes pediatric high-grade gliomas paediatric high-grade gliomas brainstem high-grade glioma pmc beta search �tumour compartment oligo/astro” 2-oxoglutarate-dependent dioxygenase inhibition cell–matrix adhesion—confirming necker-enfants malades hospital loco-regional leptomeningeal spread chi-squared proportion test �cell–matrix adhesion pathways diffusion-weighted mr imaging high-grade glioma mutated histone-driven subgroups cell-cycle regulatory genes pdgfra/cen4 fish showing sainte-anne hospital classification identify gene sets translational research programme high-grade gliomas diffuse midline glioma license information pmcid distinct oncogenic programmes �ion channel activity histone h3-27 m-mutated electronic supplementary material t1-weighted sequences comparative genomic hybridization k-means subgroups identified common baseline array cp acknowledges funding h3-k27m-mutated allele programme “brainomics” de pontine tumour infiltrating diffusion maps acquired ecm receptor interaction soc clin oncol key regulatory factor 1-k27m-mutated tumours exhibit recurrent somatic mutations copy number aberrations key upstream regulator flow diagram describing empirical bayes methods invasive ovarian carcinoma supplemental figure s2a mutated h3-k27m histone somatic h3-k27m mutation
Questions {❓}
- Is biopsy safe in children with newly diagnosed diffuse intrinsic pontine glioma?
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