
NCBI . NLM . NIH . GOV {
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Title[redir]:
Obesity and cancer: mechanistic insights from transdisciplinary studies - PMC
Description:
Obesity is associated with a range of health outcomes that are of clinical and public health significance, including cancer. Herein, we summarize epidemiologic and preclinical evidence for an association between obesity and increased risk of breast ...
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Keywords {🔍}
cancer, doi, google, scholar, pubmed, breast, prostate, obesity, risk, pmc, article, free, weight, studies, metformin, mortality, association, tumor, study, diabetes, obese, mouse, patients, loss, evidence, res, cholesterol, reduced, metaanalysis, oncol, incidence, increased, growth, women, models, body, men, reported, role, statin, hormone, cancerspecific, levels, effect, mechanisms, impact, clin, screening, prev, disease,
Topics {✒️}
gonadotropin-releasing hormone analogue cancer-free morbidly obese hormone receptor-positive tumors akt/mtor pathway inhibition hormone receptor-positive cases nonsteroidal anti-inflammatory drugs early-stage breast cancer her2-positive resected tumors hormone receptor-positive disease population-based case-control study highlighted akt/mtor signaling steroidal anti-inflammatory drugs mmtv-neu female mice mmtv-tgf-alpha mice pmc beta search small gtp-binding proteins anthracene-induced mammary tumors hgf/c-met progesterone receptor-positive tumors nonsteroidal anti-inflammatory drug 2/neu-positive breast cancer her2-positive breast cancer pro-tumor pathways upregulated steroidal anti-inflammatory drug er-positive mouse model her2-positive breast cancers /neu-induced breast cancer plasma c-peptide concentration amp-activated protein kinase advanced/end stage diabetes her2-enriched breast cancers increased akt/mtor signaling er-negative breast cancers makes population-based research triple-negative breast cancer disease-free survival diet-induced obesity enhanced improve cancer-specific outcomes canadian population-based data her2-expressing mouse models hormone-dependent tumor types prediagnostic body-mass index high-grade prostate cancer high body-mass index breast cancer-specific mortality castrate-resistant prostate cancer lower cancer-specific mortality counteracting tumor-promoting properties decreased cancer-specific mortality prostate cancer-specific mortality
Questions {❓}
- Metformin in cancer therapy: a new perspective for an old antidiabetic drug?
- Prostate cancer: metformin--the new wonder drug?
- Will metformin postpone high-fat diet promotion of TRAMP mouse prostate cancer development and progression?
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