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DOI . ORG {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Keywords
  7. Topics
  8. Questions
  9. Schema
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We began analyzing https://link.springer.com/article/10.1007/s10552-009-9434-8, but it redirected us to https://link.springer.com/article/10.1007/s10552-009-9434-8. The analysis below is for the second page.

Title[redir]:
Association between plasma total cholesterol concentration and incident prostate cancer in the CLUE II cohort | Cancer Causes & Control
Description:
Statin drugs appear to protect against advanced and possibly high-grade prostate cancer, perhaps through cholesterol-lowering. Thus, we evaluated the association between plasma cholesterol and prostate cancer. We conducted a prospective study in the CLUE II cohort of Washington County, MD. Included were 6,816 male county residents aged 35+ years old who did not have a cancer diagnosis at baseline in 1989. Plasma cholesterol, measured enzymatically at baseline, was categorized by clinical cutpoints. Cox proportional hazards regression was used to estimate multivariable-adjusted hazard ratios (HR) and 95% confidence intervals (CI) for total (n = 438) and high-grade (Gleason sum ≄7, n = 137) prostate cancer. Compared to men with high cholesterol (≄240 mg/dl), men with desirable (<200 mg/dl) or borderline (200 to <240 mg/dl) levels were less likely to develop high-grade prostate cancer, particularly when restricting to organ-confined cases (HR: 0.68, 95% CI 0.40–1.18; P trend = 0.12) and among men with higher BMI (HR: 0.36, 95% CI 0.16–0.79; P trend = 0.02). Results were unchanged after excluding cholesterol-lowering drug users. Cholesterol was not associated with total prostate cancer. Our study supports two prior ones suggesting that cholesterol influences risk of high-grade prostate cancer, and indirectly supports the hypothesis that cholesterol-lowering is a mechanism by which statins are protective.

Matching Content Categories {📚}

  • Health & Fitness
  • Education
  • Science

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

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🌠 Phenomenal Traffic: 5M - 10M visitors per month


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How Does Doi.org Make Money? {💾}

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Keywords {🔍}

cancer, prostate, google, scholar, article, cholesterol, risk, pubmed, cas, association, epidemiol, study, cohort, platz, serum, health, national, research, plasma, content, helzlsouer, cholesterollowering, men, prev, usa, privacy, cookies, total, mondul, kathy, elizabeth, highgrade, statins, access, prostatic, biomarkers, institute, data, publish, search, clue, clipp, statin, drugs, prevention, american, incidence, mortality, johns, hopkins,

Topics {✒}

month download article/chapter population-based case–control study high-grade prostate cancer related subjects full article pdf privacy choices/manage cookies clue ii cohort incident prostate cancer total prostate cancer prostate cancer—hype prostate cancer progression prostatic cancer advanced prostate cancer case–control study american heart association prostate cancer risk platz ea data-based approach national cancer institute plasma cholesterol concentration european economic area organ-confined cases c-reactive protein van dijk ce dutch civil servants body mass index diet questionnaire design mercy medical center article cancer cholesterol-lowering drugs cholesterol-lowering properties conditions privacy policy trends endocrinol metab low plasma cholesterol familial combined hyperlipidemia prospective basel study serum total cholesterol low serum cholesterol public health research noncardiovascular disease mortality health study cohort accepting optional cookies flick ed site-specific cancers cholesterol influences risk check access instant access high-grade helzlsouer prevention article log

Questions {❓}

  • Solomon KR, Freeman MR (2008) Do the cholesterol-lowering properties of statins affect cancer risk?
  • Statins and prostate cancer—hype or hope?

Schema {đŸ—ș}

WebPage:
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         headline:Association between plasma total cholesterol concentration and incident prostate cancer in the CLUE II cohort
         description:Statin drugs appear to protect against advanced and possibly high-grade prostate cancer, perhaps through cholesterol-lowering. Thus, we evaluated the association between plasma cholesterol and prostate cancer. We conducted a prospective study in the CLUE II cohort of Washington County, MD. Included were 6,816 male county residents aged 35+ years old who did not have a cancer diagnosis at baseline in 1989. Plasma cholesterol, measured enzymatically at baseline, was categorized by clinical cutpoints. Cox proportional hazards regression was used to estimate multivariable-adjusted hazard ratios (HR) and 95% confidence intervals (CI) for total (n = 438) and high-grade (Gleason sum ≄7, n = 137) prostate cancer. Compared to men with high cholesterol (≄240 mg/dl), men with desirable (<200 mg/dl) or borderline (200 to <240 mg/dl) levels were less likely to develop high-grade prostate cancer, particularly when restricting to organ-confined cases (HR: 0.68, 95% CI 0.40–1.18; P trend = 0.12) and among men with higher BMI (HR: 0.36, 95% CI 0.16–0.79; P trend = 0.02). Results were unchanged after excluding cholesterol-lowering drug users. Cholesterol was not associated with total prostate cancer. Our study supports two prior ones suggesting that cholesterol influences risk of high-grade prostate cancer, and indirectly supports the hypothesis that cholesterol-lowering is a mechanism by which statins are protective.
         datePublished:2009-10-06T00:00:00Z
         dateModified:2009-10-06T00:00:00Z
         pageStart:61
         pageEnd:68
         sameAs:https://doi.org/10.1007/s10552-009-9434-8
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            Prostatic neoplasms
            Cholesterol
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            Biomedicine
            general
            Oncology
            Public Health
            Epidemiology
            Hematology
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      headline:Association between plasma total cholesterol concentration and incident prostate cancer in the CLUE II cohort
      description:Statin drugs appear to protect against advanced and possibly high-grade prostate cancer, perhaps through cholesterol-lowering. Thus, we evaluated the association between plasma cholesterol and prostate cancer. We conducted a prospective study in the CLUE II cohort of Washington County, MD. Included were 6,816 male county residents aged 35+ years old who did not have a cancer diagnosis at baseline in 1989. Plasma cholesterol, measured enzymatically at baseline, was categorized by clinical cutpoints. Cox proportional hazards regression was used to estimate multivariable-adjusted hazard ratios (HR) and 95% confidence intervals (CI) for total (n = 438) and high-grade (Gleason sum ≄7, n = 137) prostate cancer. Compared to men with high cholesterol (≄240 mg/dl), men with desirable (<200 mg/dl) or borderline (200 to <240 mg/dl) levels were less likely to develop high-grade prostate cancer, particularly when restricting to organ-confined cases (HR: 0.68, 95% CI 0.40–1.18; P trend = 0.12) and among men with higher BMI (HR: 0.36, 95% CI 0.16–0.79; P trend = 0.02). Results were unchanged after excluding cholesterol-lowering drug users. Cholesterol was not associated with total prostate cancer. Our study supports two prior ones suggesting that cholesterol influences risk of high-grade prostate cancer, and indirectly supports the hypothesis that cholesterol-lowering is a mechanism by which statins are protective.
      datePublished:2009-10-06T00:00:00Z
      dateModified:2009-10-06T00:00:00Z
      pageStart:61
      pageEnd:68
      sameAs:https://doi.org/10.1007/s10552-009-9434-8
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         Cohort studies
         Prostatic neoplasms
         Cholesterol
         Cancer Research
         Biomedicine
         general
         Oncology
         Public Health
         Epidemiology
         Hematology
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               name:Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, USA
               type:PostalAddress
            type:Organization
            name:Johns Hopkins Medical Institutions
            address:
               name:Sidney Kimmel Comprehensive Cancer, Johns Hopkins Medical Institutions, Baltimore, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
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      name:Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA
      name:Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA
      name:George W. Comstock Center for Public Health Research and Prevention, Johns Hopkins Bloomberg School of Public Health, Hagerstown, USA
      name:Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA
      name:George W. Comstock Center for Public Health Research and Prevention, Johns Hopkins Bloomberg School of Public Health, Hagerstown, USA
      name:Prevention and Research Center, Weinberg Center for Women’s Health and Medicine, Mercy Medical Center, Baltimore, USA
      name:Sidney Kimmel Comprehensive Cancer, Johns Hopkins Medical Institutions, Baltimore, USA
      name:Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA
      name:Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, USA
      name:Sidney Kimmel Comprehensive Cancer, Johns Hopkins Medical Institutions, Baltimore, USA
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External Links {🔗}(130)

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