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Title[redir]:
Hepatology
Description:
dilate into the biliary tree. Alagille syndrome patients, who suffer from bile duct paucity, carry Jagged1 and Notch2 mutations, indicating that Notch2 signaling is important for IHBD development. To clarify the role of Notch2 in BEC differentiation, tubulogenesis, and BEC survival, we developed a mouse model for conditional expression of activated Notch2 in the liver. We show that expression of the intracellular domain of Notch2 (Notch2ICD) differentiates hepatoblasts into BECs, which form additional bile ducts in periportal regions and ectopic ducts in lobular regions. Additional ducts in periportal regions are maintained into adulthood and connect to the biliary tight junction network, resulting in an increased number of bile ducts per portal tract. Remarkably, Notch2ICD-expressing ductal plate remnants were not eliminated during postnatal development, implicating Notch2 signaling in BEC survival. Ectopic ducts in lobular regions did not persist into adulthood, indicating that local signals in the portal environment are important for maintaining bile ducts. Conclusion: Notch2 signaling regulates BEC differentiation, the induction of tubulogenesis during IHBD development, and BEC survival. (Hepatology 2009.)...
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Keywords {๐}
notch, liver, ducts, bile, bec, aasld, hepatology, log, journal, development, ductal, plate, signaling, regions, access, subscribe, issue, alerts, abstract, ihbd, differentiation, biliary, survival, register, member, logo, browse, submit, article, buy, intrahepatic, duct, hepatoblasts, cell, indicating, important, tubulogenesis, mouse, expression, additional, periportal, ectopic, lobular, adulthood, portal, regulates, copyright, american, association, study,
Topics {โ๏ธ}
aasld members log open access policy bile duct paucity individual subscribers log institutional users access liver diseases ductal plate remodeling tubular structures arise alagille syndrome patients immunological organ back artificial intelligence training forming bile ducts maintaining bile ducts implicating notch2 signaling full text access hepatology 2009 journal tables register subscribe mouse model service request 800-638-3030 ductal plate bile ducts notch2 signaling biliary tree additional ducts liver compromises intrahepatic bec differentiation journal website subscribe ectopic ducts bec survival notch2 mutations activated notch2 development begins distinct sites carry jagged1 intracellular domain periportal regions lobular regions increased number portal tract postnatal development local signals portal environment ๏ฟฝdimensional architecture surface markers email inbox rights reserved data mining
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